Folate and homocysteine levels in pregnancy

British Journal of Biomedical Science

Volumn 61, Issue 2, 2004, Pages 84-87

  Megahed, M A ^a   Taher, I M ^b  

^a ALEXANDRIA UNIVERSITY   (Egypt)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

Folic acid; Homocysteine; Pregnancy

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; SERUM ALBUMIN;

ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ERYTHROCYTE; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; NORMAL HUMAN; PREGNANCY; PRIORITY JOURNAL; VENOUS BLOOD; VITAMIN BLOOD LEVEL;

EID: 3042797836     PISSN: 09674845     EISSN: None     Source Type: Journal    
DOI: 10.1080/09674845.2004.11732649     Document Type: Article

References (36)

1. Hague WM. Homocysteine and pregnancy. Best Pract Res Clin Obstet Gynaecol 2003; 17(3): 459-69.
2. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr 2000; 71 (5 Suppl): 1295S-303S.
3. Ackurt F, Wetherilt H, Loker M, Hacibekiro M. Biochemical assessment of nutritional status in pre- and post-natal Turkish women and outcome of pregnancy. Eur J Clin Nutr 1995; 49: 613-22.
4. Bruinse HW, Van den Berg H. Changes of some vitamin levels during and after normal pregnancy. Eur J Obstet Gynecol Reprod Biol 1995; 61: 31-7.
5. Mudd SH, Levy HL, Skovby F. Disorders in transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The metabolic and molecular basis of molecular disease. New York: McGraw-Hill, 1995: 1279-327.
6. Picciano MF. Is homocysteine a biomarker for identifying women at risk of complications and adverse pregnancy outcomes? Am J Clin Nutr 2000; 71: 857-8.
7. Walker MC, Smith GN, Perkins SL, Keely EJ, Garner PR. Changes in homocysteine levels during normal pregnancy. Am J Obstet Gynecol 1999; 180: 660-4.
8. Vollset SE, Refsum H, Irgens LM et al. Plasma total homocysteine, pregnancy complications and adverse pregnancy outcomes: The Hordaland Study. Am J Clin Nutr 2000; 71: 962-8.
9. 12. J Clin Pathol 1980; 33: 234-42.
10. Frantzen F, Faaren AL, Alfheim I, Nordhei AK. An enzyme conversion immunoassay for determining total homocysteine in plasma or serum. Clin Chem 1998; 44: 311-6.
11. Peters T Jr, Biamonte GT, Doumas BT. Protein (total protein) in serum, urine and cerebrospinal fluid, albumin in serum. In: Faulkner WR, Meites S, eds. Selected methods of clinical chemistry (Vol. 9). Washington DC: American Association for Clinical Chemistry, 1982.
12. International Committee for Standardization in Haematology. Recommendation for haemoglobinometry in human blood (ICSH standard EP 6/2: 1977) and specifications for international haemoglobincyanide preparation (ICSH standard EP 6/3: 1977). J Clin Pathol 1978; 31: 139-43.
13. Williams WJ. Examination of the blood. In: Williams WJ, Buetler E, Erslev AJ, Lichtman MA, eds. Hematology (3rd edn). New York: McGraw-Hill, London, 1983: 9-24.
14. Wilkinson JH, Baron DN, Moss DW, Walker PG. Standardization of clinical enzyme assays. A reference method for aspartate and alanine transaminases. J Clin Pathol 1972; 25: 940.
15. Pietrzik KF, Thorand B. Folate economy in pregnancy. Nutrition 1997; 13: 975-7.
16. Steegers-Theunissen RPM, Smith SC, Steegers EAP, Guilbert LJ, Baker PN. Folate affects apoptosis in human trophoblastic cells. Br J Obstet Gynaecol 2000; 107: 1513-5.
17. Khong TY, Hague WM. The placenta in maternal hyperhomocysteinemia. Br J Obstet Gynaecol 1999; 106: 273-8.
18. Higgins JR, Quinlan EP McPartlin J, Scott JM, Weir DG, Darling MRN. The relationship between increased folate catabolism and the increased requirement for folate in pregnancy. Br J Obstet Gynaecol 2000; 107: 1149-54.
19. Steegers-Theunissen RPM, Boers GHJ, Blom HJ et al. Neural tube defects and elevated homocysteine levels in amniotic fluid. Am J Obstet Gynecol 1995; 172: 1436-41.
20. Steegers-Theunissen RPM, Wathen NC, Eskes TKAB, Raaij-Selten BV, Chard T. Maternal and fetal levels of methionine and homocysteine in early human pregnancy. Br J Obstet Gynaecol 1997; 104: 20-4.
21. Seyoum G, Persaud TV. In vitro effects of S-adenosyl methionine on ethanol embryopathy in the rat. Exp Toxicol Pathol 1994; 46: 177-81.
22. Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest 1986; 77: 1370-6.
23. Acrtsvan LAGJM, Blom HJ, Abreu de RA et al. Prevention of neural tube defects by and toxicity of L-homocysteine in cultured post-implantation rat embryos. Teratology 1994; 50: 348-60.
24. Mills JL, McPartlin JM, Kirke PN et al. Homocysteine metabolism in pregnancies complicated by neural tube defects. Lancet 1995; i: 149-51.
25. Malinow MR, Rajkovic A, Duell PB, Hess DL, Upson BM. The relationship between maternal and neonatal umbilical cord plasma homocysteine suggests a potential role for maternal homocysteine in fetal metabolism. Obstet Gynecol 1998; 178: 228-33.
26. Den Heijer M, Koster T, Blom HJ et al. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. N Engl J Med 1996; 334: 759-62.
27. Chambers JC, McGregor A, Jean-Marie J, Kooner JS. Acute hyperhomocysteinemia and endothelial dysfunction [Letter]. Lancet 1997; 351: 36-7.
28. Welch GN, Upchurch G Jr, Loscalzo J. Hyperhomocysteinemia and atherothrombosis. Ann N Y Acad Sci 1997; 811: 48-58.
29. Rodgers GM, Conn MT. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood 1990; 75: 895-901.
30. Walker MC, Smith GN, Perkins SL, Keely EJ, Garner PR. Changes in homocysteine levels during normal pregnancy. Am J Obstet Gynecol 1999; 180: 660-4.
31. Selhub J, Jacques PF, Bostom AG. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995; 332: 286-91.
32. Smits LJM, Essed GGM. Short interpregnancy intervals and unfavourable pregnancy outcome: role of folate depletion. Lancet 2001; 358(9298): 2074.
33. Tamura T, Goldenberg RL, Johnston KE, Dubard M. Maternal plasma zinc concentrations and pregnancy outcome. Am J Clin Nutr 2000; 71: 109-13.
34. Bendich A. Micronutrients in women's health and immune function. Nutrition 2001; 17(10): 858-67.
35. Todoroff K, Shaw GM. Prior spontaneous abortion, prior elective termination, interpregnancy interval and risk of neural tube defects. Am J Epidemiol 2000; 151: 505-11.
36. Zhu BPl, Rolfs RT, Nangle BE, Horan JM. Effect of the interval between pregnancies on perinatal outcomes. N Engl J Med 1999; 340: 589-94.