Effects of γ-hydroxybutyrate on cerebrospinal fluid lactate and glucose levels after spinal cord trauma

Journal of Clinical Neuroscience

Volumn 11, Issue 5, 2004, Pages 517-520

  Güney, Önder ^a   Celik, Jale Bengi ^a   Arazi, Mehmet ^a   Ustun, Mehmet Erkan ^a  

^a SELCUK UNIVERSITY   (Turkey)

Author keywords

hydroxybutyrate; cerebrospinal fluid; spinal cord trauma

Indexed keywords

4 HYDROXYBUTYRIC ACID; GLUCOSE; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID FLOW; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG SCREENING; INTERMETHOD COMPARISON; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPINAL CORD INJURY; STATISTICAL SIGNIFICANCE;

ADJUVANTS, ANESTHESIA; ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; GLUCOSE; HEART RATE; LACTIC ACID; LIPID PEROXIDATION; MALE; RABBITS; SODIUM OXYBATE; SPINAL CORD INJURIES; TIME FACTORS;

EID: 3042788525     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2003.10.019     Document Type: Article

References (21)

1. Dumont R.J., Okonkwo D.O., Verma S., Hurlbert R.J., Boulos P., Ellegala D.B., Dumont A.S. Acute spinal cord injury, part I: pathophysiologic mechanisms. Clin. Neuropharmacol. 24:2001;254-264
2. Sekhon L.H.S., Fehlings M.G. Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine. 26:2001;2-24
3. Vaccaro A.R., Singh K. Pharmacologic treatment and surgical timing for spinal cord injury. Curr. Opin. Orthop. 10:1999;112-116
4. Akpek E.A., Bulut E., Alanay A., Korkusuz P., Acarolu E., Kilin K. A study of adenosine treatment in experimental acute spinal cord injury: effect on arachidonic acid metabolites. Spine. 24:1999;128-132
5. Wilson J.X., Gelb A.W. Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics. J. Neurosurg. Anesthesiol. 14:2002;66-79
6. Donovan J.W. γ-Hydroxybutyrate, γ-butyrolactone, and butanediol: abuse and effects. J. Toxicol. Clin. Toxicol. 38:2000;183
7. Mamelak M. γ-Hydroxybutyrate: an endogenous regulator of energy metabolism. Neurosci. Biobehav. Rev. 13:1989;187-198
8. Tunnicliff G. Significance of γ-hydroxybutyric acid in the brain. Gen. Pharmacol. 23:1992;1027-1034
9. Okun M.S. GHB: an important pharmacologic and clinical update. J. Pharm. Pharmaceut. Sci. 4:2001;167-175
10. Li J., Stokes S.A., Woeckener A. A tale of novel intoxication: a review of the effects of γ-hydroxybutyric acid with recommendations for management. Ann. Emerg. Med. 31:1998;729-736
11. Anderson D.K., Prockop L.D., Means E.D., Hartley L.E. Cerebrospinal fluid lactate and electrolyte levels following experimental spinal cord injury. J. Neurosurg. 44:1976;715-722
12. Nagy G., Dzsinich C., Selmeci L., Sepa G., Dzsinich M., Kekesi V., Juhasz-Nagy A. Biochemical alterations in cerebrospinal fluid during thoracoabdominal aortic cross-clamping in dogs. Ann. Vasc. Surg. 16(4):2002;436-441
13. Üstün M.E., Gürbilek M., Ak A., Vatansev H., Duman A. Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma. Intensive Care Med. 27:2001;264-268
14. Krishnappa I.K., Contant C.F., Robertson C.S. Regional changes in cerebral extracellular glucose and lactate concentrations following severe cortical impact injury and secondary ischemia in rats. J. Neurotrauma. 16:1999;213-224
15. Dreher W., Kahn B., Cyngell M.L., Busch E., Niendorf T., Hossmann K.A., Leibfritz D. Temporal and regional changes during focal ischemia in rat brain studied by proton spectroscopic imaging and quantitative diffusion NMR imaging. Magn. Reson. Med. 39:1998;878-888
16. Farooque M., Isaksson J., Jackson D.M., Olsson Y. Clomethiazole improves hind limb motor function and reduces neuronal damage after severe spinal cord injury in rat. Acta Neuropathol. 98:1999;22-30
17. Penn R.D. Spasticity. Wilkins R.H., Rengechary S.S. Neurosurgery. 1996;477-481 McGraw-Hill, New York
18. Jensen K., Mody I. GHB depresses fast excitatory and inhibitory synaptic transmission via GABA (B) receptors in mouse neocortical neurons. Cereb. Cortex. 11:2001;424-429
19. Osorio I., Davidoff R.A. γ-Hydroxybutyric acid is not a GABA-mimetic agent in the spinal cord. Ann. Neurol. 6:1979;111-116
20. Hosli L., Hosli E., Lehmann R., Scneider J., Borner M. Action of γ-hydroxybutyrate and GABA on neurones of cultured rat central nervous system. Neurosci. Lett. 37:1983;257-260
21. Senter H.J., Venes J.L., Kauer J.S. Alteration of posttraumatic ischemia in experimental spinal cord trauma by a central nervous system depressant. J. Neurosurg. 50:1979;207-216