Pharmacologic treatment and surgical timing for spinal cord injury

Current Opinion in Orthopaedics

Volumn 10, Issue 2, 1999, Pages 112-116

  Vaccaro, Alexander R ^a,c   Singh, Kush ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c ROTHMAN INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE;

HOSPITALIZATION; HUMAN; PRIORITY JOURNAL; REVIEW; SPINAL CORD DECOMPRESSION; SPINAL CORD INJURY; SPINE STABILIZATION; TREATMENT INDICATION;

EID: 0032778169     PISSN: 10419918     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001433-199904000-00005     Document Type: Review

References (17)

1. Rosenfeld JF, Vaccaro AR, Albert TJ, Klein GR, Cotler JM: The benefits of early decompression in cervical spinal cord injury. Am J Orthop 1998, 1:23-28. An excellent review of experimental and clinical research that clarifies the benefits of early surgery for cervical spinal cord injury. Pathophysiology and pharmacology are also reviewed.
2. Sonntag VKH, Francis PM: Patient selection and timing of surgery. In Contemporary Management of Spinal Cord Injury. Edited by Benzel EC, Tator CH. Park Ridge, IL: American Association of Neurologic Surgeons; 1995:97-108.
3. Vaccaro AR, Daugherty RJ, Sheehan TP, Dante SJ, Cotler JM, Balderston RA, Herbison GJ, Northrup BE: Neurologic outcome of early versus late surgery for cervical spinal cord injury. Spine 1997, 22(22):2609-2613. A prospective analysis that evaluates neurologic outcome after early versus late surgery for cervical spinal cord trauma.
4. Glaser JA, Jaworski BA, Cuddy BG, Albert TJ, Hollowell JP, McLain RF. Bozzette SA: Variation in surgical opinion regarding management of selected cervical spine injuries: a preliminary study. Spine 1998, 23(9):975-982.
5. Delamarter RB, Sherman J, Carr JB: Pathophysiology of spinal cord injury: recovery after immediate and delayed decompression. J Bone Joint Surg Am 1995, 77A:1042-1049.
6. Salzman SK, Betz RR: Experimental treatment of spinal cord injuries. In The Child with a Spinal Cord Inury. Edited by Betz RR, Mulcaheny MJ. Rosemont, IL: American Association of Orthopaedic Surgeons; 1996:63.
7. Bracken MB, Shepard MJ, Collins WF, Holford TR, Young W, Baskin DS: A randomized, controlled trial of methylpredisolone or naloxone in the treatment of acute spinal-cord injury. N Engl J Med 1990, 322:1405-1411.
8. Geisler FH: Past and current human spinal cord injury drug trials. In Contemporary Management of Spinal Cord Injury. Edited by Benzel EC, Tator CH. Park Ridge, IL: American Association of Neurologic Surgeons; 1995:261-268.
9. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, et al.: Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury: results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997, 277(20):1597-1604. This article describes the NASCIS III trials between methylprednisolone and tirilazad mesylate in acute spinal cord injury.
10. Petitjean ME, Pointillart V, Dixmerias F, Wiart L, Sztark F, Lassie P, et al.: Medical treatment of spinal cord injury in the acute stage. Ann Fr Anesth Reanim 1998, 17(2):114-122.
11. Sharma HS, Westman J, Nyberg F: Topical application of 5-HT antibodies reduces edema and cell changes following trauma of the rat spinal cord. Acta Neurochir Suppl (Wein) 1997, 70:155-158.
12. Winkler T, Sharma HS, Stalberg E, Westman J: Benzodiazepine receptors influence spinal cord evoked potentials and edema following trauma to the rat spinal cord. Acta Neurochir Suppl (Wein) 1997, 70:216-219.
13. Attar A, Tuna H, Sargon MF, Yuceer N, Turker RK, Egernen N: Early protective effects of lloprost after experimental spinal cord injury. Neurol Res 1998, 20(4):353-359.
14. Levi L, Wolf A, Rigamonti D, et al.: Anterior decompression in cervical spine trauma: does the timing of surgery affect the outcome. Neurosurgery 1991, 29:216-222.
15. Carlson GD, Minato Y, Okada A, Gorden CD, Warden KE, Barbeau JM, et al.: Early time-dependent decompression for spinal cord injury: vascular mechanisms of recovery. J Neurotrauma 1997, 14(12):951-962.
16. Campagnolo DI, Esquieres RE, Kopacz KJ: Effect of timing of stabilization on length of stay and medical complications following spinal cord injury. J Spinal Cord Med 1997, 20(3):331-334.
17. Vale FL, Burns J, Jackson AB, Hadley MN: Combined medical and surgical treatment after acute spinal cord injury: results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management. J Neurosurg 1997, 87(2):239-246.