LPS binding protein does not participate in the pharmacokinetics of E5564

Journal of Endotoxin Research

Volumn 10, Issue 3, 2004, Pages 185-194

  Kaneko, Kazuhiro ^a   Ueda, Rika ^a   Kawata, Tsutomu ^a   Ishizaka, Sally ^a,b   Yoshimura, Tsutomu ^a  

^a EISAI CO LTD   (Japan)

^b EISAI RESEARCH INSTITUTE   (United States)

Author keywords

E5564; Lipid A analogue; Lipopolysaccharide; Lipopolysaccharide binding protein; Pharmacokinetics

Indexed keywords

CARBON 14; E 5564; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HEPARIN; HIGH DENSITY LIPOPROTEIN; LIPID A DERIVATIVE; LIPOPOLYSACCHARIDE BINDING PROTEIN; MANGANESE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG LABELING; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ESCHERICHIA COLI; FEMALE; GEL FILTRATION CHROMATOGRAPHY; HUMAN; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRECIPITATION; SEPSIS; SEPTIC SHOCK; SURFACE PLASMON RESONANCE; WILD TYPE;

ACUTE-PHASE PROTEINS; ANIMALS; ANTIBODY FORMATION; ANTICOAGULANTS; CARRIER PROTEINS; DRUG INTERACTIONS; FEMALE; HEPARIN; LIPID A; LIPOPOLYSACCHARIDES; MANGANESE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PRECIPITATION; SHOCK, SEPTIC;

EID: 3042771807     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805104225004860     Document Type: Article

References (38)

1. Glauser MP, Zanetti G, Baumgartner JD, Cohen J. Septic shock: pathogenesis. Lancet 1991; 338: 732-736.
2. Rietschel ET, Kirikae T, Schade F et al. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J 1994; 8: 217-225.
3. Raetz CR. Biochemistry of endotoxins. Annu Rev Biochem 1990; 59: 129-170.
4. Zähringer U, Lindner B, Rietschel ET. Chemical structure of lipid A: Recent advances in structural analysis of biologically active molecules. In: Brade H, Opal SM, Vogel SN, Morrison DC. (eds) Endotoxin in Health and Disease. New York: Marcel Dekker, 1999; 93-114.
5. Loppnow H, Libby P, Freudenberg M, Krauss JH, Weckesser J, Mayer H. Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS. Infect Immun 1990; 58: 3743-3750.
6. Takayama K, Qureshi N, Beutler B, Kirkland TN. Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide. Infect Immun 1989; 57: 1336-1338.
7. Qureshi N, Takayama K, Kurtz R. Diphosphoryl lipid A obtained from the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides is an endotoxin antagonist in mice. Infect Immun 1991; 59: 441-444.
8. Aida Y, Kusumoto K, Nakatomi K, Takada H, Pabst MJ, Maeda K. An analogue of lipid A and LPS from Rhodobacter sphaeroides inhibits neutrophil responses to LPS by blocking receptor recognition of LPS and by depleting LPS-binding protein in plasma. J Leukoc Biol 1995; 58: 675-682.
9. Rossignol DP, Hawkins LD, Christ WJ et al. Synthetic endotoxin antagonists. In: Brade H, Opal SM, Vogel SN, Morrison DC. (eds) Endotoxin in Health and Disease. New York: Marcel Dekker, 1999; 699-717.
10. Rossignol DP, Lynn M. Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue. J Endotoxin Res 2002; 8: 483-488.
11. Lynn M, Wong YN, Wheeler JL et al. Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia. J Pharmacol Exp Ther 2004; 308: 175-181.
12. Wong YN, Rossignol D, Rose JR, Kao R, Carter A, Lynn M. Safety, pharmacokinetics, and pharmacodynamics of E5564, a lipid A antagonist, during an ascending single-dose clinical study. J Clin Pharmacol 2003; 43: 735-742.
13. Kaneko K, Ueda R, Kikuchi K, Sano Y, Yoshimura T. Quantitative determination of a potent lipopolysaccharide antagonist, E5564, in rat and dog plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl 1999; 736: 67-75.
14. Kaneko K, Ueda R, Nemoto H, Iijima H, Yoshimura T. Disposition of a synthetic analogue of lipid A (E5564) in rats. Xenobiotica 2003; 33: 323-339.
15. Mathison JC, Ulevitch RJ. The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits. J Immunol 1979; 123: 2133-2143.
16. Mathison JC, Ulevitch RJ. Uptake and subcellular localization of bacterial lipopolysaccharide in the adrenal gland. Am J Pathol 1985; 120: 79-86.
17. Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 1996; 271: 518-520.
18. Harris HW, Grunfeld C, Feingold KR et al. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. J Clin Invest 1993; 91: 1028-1034.
19. Hailman E, Lichenstein HS, Wurfel MM et al. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J Exp Med 1994; 179: 269-277.
20. Wurfel MM, Hailman E, Wright SD. Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein. J Exp Med 1995; 181: 1743-1754.
21. Tobias PS, Soldau K, Gegner JA, Mintz D, Ulevitch RJ. Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J Biol Chem 1995; 270: 10482-10488.
22. Rose JR, Mullarkey MA, Christ WJ et al. Consequences of interaction of a lipophilic endotoxin antagonist with plasma lipoproteins. Antimicrob Agents Chemother 2000; 44: 504-510.
23. Yu B, Wright SD. Catalytic properties of lipopolysaccharide (LPS) binding protein. Transfer of LPS to soluble CD14. J Biol Chem 1996; 271: 4100-4105.
24. de Haas CJ, van Leeuwen HJ, Verhoef J, van Kessel KP, van Strijp JA. Analysis of lipopolysaccharide (LPS)-binding characteristics of serum components using gel filtration of FITC-labeled LPS. J Immunol Methods 2000; 242: 79-89.
25. Levels JH, Abraham PR, van den Ende A, van Deventer SJ. Distribution and kinetics of lipoprotein-bound endotoxin. Infect Immun 2001; 69: 2821-2828.
26. Fägerstam LG, Frostell Å, Karlsson R et al. Detection of antigen-antibody interactions by surface plasmon resonance. Application to epitope mapping. J Mol Recog 1990; 3: 208-214.
27. Löfås S, Johnsson B. A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands. J Chem Soc Chem Commun 1990; 21: 1526-1528.
28. Wurfel MM, Monks BG, Ingalls RR et al. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J Exp Med 1997; 186: 2051-2056.
29. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem 1974; 20: 470-475.
30. Doumas BT, Watson WN, Biggs HG. Albumin standards and the measurement of serum albumin with bromocresol green. Clin Chim Acta 1971; 31: 87-96.
31. Demacker PN, Hessels M, Toenhake-Dijkstra H, Baadenhuijsen H. Precipitation methods for high-density lipoprotein cholesterol measurement compared, and final evaluation under routine operating conditions of a method with a low sample-to-reagent ratio. Clin Chem 1997; 43: 663-668.
32. David SA, Balaram P, Mathan VI. Characterization of the interaction of lipid A and lipopolysaccharide with human serum albumin: implication for an endotoxin carrier function for albumin. J Endotoxin Res 1995; 2: 99-106.
33. Jurgens G, Muller M, Garidel P et al. Investigation into the interaction of recombinant human serum albumin with Re-lipopolysaccharide and lipid A. J Endotoxin Res 2002; 8: 115-126.
34. Vreugdenhil AC, Snoek AM, van't Veer C, Greve JW, Buurman WA. LPS-binding protein circulates in association with apoB-containing lipoproteins and enhances endotoxin-LDL/VLDL interaction. J Clin Invest 2001; 107: 225-234.
35. Hampton RY, Raetz CR. Macrophage catabolism of lipid A is regulated by endotoxin stimulation. J Biol Chem 1991; 266: 19499-19509.
36. Schletter J, Heine H, Ulmer AJ, Rietschel ET. Molecular mechanisms of endotoxin activity. Arch Microbiol 1995; 164: 383-389.
37. Munford RS, Hall CL, Dietschy JM. Binding of Salmonella typhimurium lipopolysaccharides to rat high-density lipoproteins. Infect Immun 1981; 34: 835-843.
38. Van Lenten BJ, Fogelman AM, Haberland ME, Edwards PA. The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide. Proc Natl Acad Sci USA 1986; 83: 2704-2708.