Influence of beta-amyloid fibrils on the interactions between red blood cells and endothelial cells

Neurological Research

Volumn 26, Issue 5, 2004, Pages 579-585

  Ravi, Luke B ^a   Mohanty, Joy G ^a   Chrest, Francis J ^b   Jayakumar, Rajadas ^a,c,e   Nagababu, Enika ^a   Usatyuk, Peter V ^d   Natarajan, Viswanathan ^d   Rifkind, Joseph M ^a,c  

^a Molecular Dynamics Section   (United States)

^b Clinical Research Branch   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e CENTRAL LEATHER RESEARCH INSTITUTE   (India)

Author keywords

Beta amyloid, A 1 40; Endothelial cells; Erythrocytes; Flow cytometry; Microvascular cells

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN BLOOD FLOW; BRAIN MICROCIRCULATION; CELL ADHESION; CELL INTERACTION; CELL TRANSFER; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTHELIUM CELL; ERYTHROCYTE; FLOW CYTOMETRY; MOUSE; NONHUMAN; VASCULAR AMYLOIDOSIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CATTLE; CELL ADHESION; CELL COMMUNICATION; CELLS, CULTURED; CEREBRAL AMYLOID ANGIOPATHY; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; ENDOTHELIAL CELLS; ERYTHROCYTES; FLOW CYTOMETRY; MALE; MICE; MICE, INBRED C57BL; MICROCIRCULATION;

EID: 3042757587     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164104225016227     Document Type: Article

References (21)

1. Carter J, Lippa CF. Beta-amyloid, neuronal death and Alzheimer's disease. Curr Mol Med 2001; 1: 733-737
2. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-356
3. de la Torre JC. Vascular basis of Alzheimer's pathogenesis. Ann N Y Acad Sci 2002; 977: 196-215
4. Ozawa K, Tomiyama T, Maat-Schieman ML, et al. Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D). Ann N Y Acad Sci 2002; 977: 149-154
5. Mackic JB, Weiss MH, Miao W, et al. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem 1998; 70: 210-215
6. Varadarajan S, Yatin S, Aksenova M, Butterfield DA. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 2000; 130: 184-208
7. Jayakumar R, Kusiak JW, Chrest FJ, et al. Red cell perturbations by amyloid beta-protein. Biochim Biophys Acta 2003; 1622: 20-28
8. Stoltz JF, Muller S, Wang X, et al. Hemorheology and vascular endothelial cells. Clin Hemorheol Microcirc 1999; 20: 127-139
9. Usatyuk PV, Fomin VP, Shi S, et al. Role of Ca2+ in diperoxovanadate- induced cytoskeletal remodeling and endothelial cell barrier function. Am J Physiol Lung Cell Mol Physiol 2003; 285: L1006-1017
10. Roy S, Parinandi N, Zeigelstein R, et al. Hyperoxia alters phorbol ester-induced phospholipase D activation in bovine lung microvascular endothelial cells. Antioxid Redox Signal 2003; 5: 217-228
11. Grammas P, Yamada M, Zlokovic B. The cerebromicrovasculature: A key player in the pathogenesis of Alzheimer's disease. J Alzheimer's Dis 2002; 4: 217-223
12. Rhodin JA, Thomas T. A vascular connection to Alzheimer's disease. Microcirculation 2001; 8: 207-220
13. Borroni B, Akkawi N, Martini G, et al. Microvascular damage and platelet abnormalities in early Alzheimer's disease. J Neurol Sci 2002; 203-204: 189-193
14. Farkas E, Luiten PG. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol 2001; 64: 575-611
15. Nagababu E, Rifkind JM. Heme degradation during autoxidation of oxyhemoglobin. Biochem Biophys Res Commun 2000; 273: 839-845
16. Yedgar S, Koshkaryev A, Barshtein G. The red blood cell in vascular occlusion. Pathophysiol Haemost Thromb 2002; 32: 263-268
17. Ravi LB, Poosala S, Ahn D, et al. Red cell interactions with amyloid beta1-40 fibrils in a murine model. Manuscript Submitted
18. Mattson MP, Begley JG, Mark RJ, et al. Abeta25-35 induces rapid lysis of red blood cells: contrast with Abeta1-42 and examination of underlying mechanisms. Brain Res 1997; 771: 147-153
19. Rifkind JM, Abugo OO, Peddada RR, et al. Maze learning impairment is associated with stress hemopoiesis induced by chronic treatment of aged rats with human recombinant erythropoietin. Life Sci 1999; 64: 237-247
20. Chen M, Inestrosa NC, Ross GS, et al. Platelets are the primary source of amyloid beta-peptide in human blood. Biochem Biophys Res Commun 1995; 213: 96-103
21. Jayakumar R, Kusiak JW, Chrest FJ, and Rifkind JM. Unpublished results