Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase

Analytical Biochemistry

Volumn 331, Issue 1, 2004, Pages 198-200

  Kurkela, Mika ^a   Siiskonen, Antti ^a   Finel, Moshe ^a   Tammela, Päivi ^a   Taskinen, Jyrki ^a   Vuorela, Pia ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

CATECHOL-O-METHYLTRANSFERASE; MICROPLATES; SCREENING ASSAYS;

CHEMISTRY;

ADRENALIN; CATECHOL DERIVATIVE; CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; NORADRENALIN; XENOBIOTIC AGENT;

ARTICLE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROTITER PLATE ASSAY; PRIORITY JOURNAL; RELIABILITY; REPRODUCIBILITY;

EID: 3042753797     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(04)00370-7     Document Type: Article

References (11)

1. Männistö P.T., Kaakkola S. Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol. Rev. 51:1999;593-628
2. Lautala P., Ulmanen I., Taskinen J. Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. Mol. Pharmacol. 59:2001;393-402
3. Acuña G., Foernzler D., Leong D., Rabbia M., Smit R., Dorflinger E., Gasser R., Hoh J., Ott J., Borroni E., To Z., Thompson A., Li J., Hashimoto L., Lindpaintner K. Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity. Pharmacogen. J. 2:2002;327-334
4. Parada A., Loureiro A.I., Vieira-Coelho M.A., Hainzl D., Soares-da-Silva P. BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation. Eur. J. Pharmacol. 420:2001;27-32
5. Pihlavisto P., Reenila I. Separation methods for catechol O-methyltransferase activity assay: physiological and pathophysiological relevance. J. Chromatogr. B. 781:2002;359-372
6. Veser J. Kinetics and inhibition studies of catechol O-methyltransferase from the yeast Candida tropicalis. J. Bacteriol. 169:1987;3696-3700
7. Van Dyck S., Van Schepdael A., Hoogmartens J. Off-line and on-line determination of catechol-O-methyltransferase activity in a capillary electrophoretic system. Electrophoresis. 23:2002;1341-1347
8. Tilgmann C., Kalkkinen N. Purification and partial sequence analysis of the soluble catechol-O-methyltransferase from human placenta: comparison to the rat liver enzyme. Biochem. Biophys. Res. Commun. 174:1991;995-1002
9. Bäckström R., Honkanen E., Pippuri A., Kairisalo P., Pystynen J., Heinola K., Nissinen E., Linden I.-B., Männistö P.T., Kaakkola S., Pohto P. Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors. J. Med. Chem. 32:1989;841-846
10. Bollini S., Herbst J.J., Gaughan G.T., Verdoorn T.A., Ditta J., Dubowchik G.M., Vinitsky A. High-throughput fluorescence polarization method for identification of FKBP12 ligands. J. Biomol. Screen. 7:2002;526-530
11. Zhang J.H., Chung T.D.Y., Oldenburg K.R. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4:1999;67-73