Metabotropic glutamate receptors are differentially regulated under elevated intraocular pressure

Journal of Neurochemistry

Volumn 90, Issue 1, 2004, Pages 190-202

  Dyka, Frank M ^a   May, Christian A ^a   Enz, Ralf ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Apoptosis; Gene expression; Glaucoma; Immunocytochemistry; Retina; RT PCR

Indexed keywords

METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1A; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 4B; METABOTROPIC RECEPTOR 5A; METABOTROPIC RECEPTOR 5B; METABOTROPIC RECEPTOR 6; METABOTROPIC RECEPTOR 7A; METABOTROPIC RECEPTOR 8B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLINDNESS; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GLAUCOMA; IMMUNOHISTOCHEMISTRY; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GLAUCOMA, ANGLE-CLOSURE; INTRAOCULAR PRESSURE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RETINA; RETINAL GANGLION CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

ANIMALIA;

EID: 3042729684     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02474.x     Document Type: Article

References (51)

1. Anderson M. G., Smith R. S., Hawes N. L., Zabaleta A., Chang B., Wiggs J. L. and John S. W. (2002) Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat. Genet. 30, 81-85.
2. Bayer A. U., Neuhardt T., May A. C., Martus P., Maag K. P., Brodie S., Lutjen-Drecoll E., Podos S. M. and Mittag T. (2001) Retinal morphology and ERG response in the DBA/2NNia mouse model of angle-closure glaucoma. Invest. Ophthalmol. Vis. Sci. 42, 1258-1265.
3. Carter-Dawson L., Crawford M. L., Harwerth R. S., Smith E. L. III, Feldman R., Shen F. F., Mitchell C. K. and Whitetree A. (2002) Vitreal glutamate concentration in monkeys with experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 43, 2633-2637.
4. Chang B., Smith R. S., Hawes N. L. et al. (1999) Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat. Genet. 21, 405-409.
5. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
6. Conn P. J. and Pin J. (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37, 205-237.
7. Dev K. K., Nakanishi S. and Henley J. M. (2001) Regulation of mglu (7) receptors by proteins that interact with the intracellular C-terminus. Trends Pharmacol. Sci. 22, 355-361.
8. Dreyer E. B., Zurakowski D., Schumer R. A., Podos S. M. and Lipton S. A. (1996) Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch. Ophthalmol. 114, 299-305.
9. Enz R. (2001) GABA (C) receptors: a molecular view. Biol. Chem. 382, 1111-1122.
10. Fingert J. H., Heon E., Liebmann J. M. et al. (1999) Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Hum. Mol. Genet. 8, 899-905.
11. Hartveit E., Brandstätter J. H., Enz R. and Wässle H. (1995) Expression of the mRNA of seven metabotropic glutamate receptors (mGluR1-7) in the rat retina. An in situ hybridization study on tissue sections and isolated cells. Eur. J. Neurosci. 7, 1472-1483.
12. Herkert M., Shakhman O., Schweins E. and Becker C.-M. (2001) Beta-bungarotoxin is a potent inducer of apoptosis in cultured rat neurons by receptor-mediated internalization. Eur. J. Neurosci. 14, 821-828.
13. Hof P. R., Lee P. Y., Yeung G., Wang R. F., Podos S. M. and Morrison J. H. (1998) Glutamate receptor subunit GluR2 and NMDAR1 immunoreactivity in the retina of macaque monkeys with experimental glaucoma does not identify vulnerable neurons. Exp. Neurol. 153, 234-241.
14. Hollmann M. and Heinemann S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108.
15. Ikeda Y., Ohguro H. and Maruyama I. (2000) Two cases of primary open-angle glaucoma with serum autoantibody against retinal ganglion cells. Jpn J. Ophthalmol. 44, 648-652.
16. Jeffery G., Sharp C., Malitschek B., Salt T. E., Kuhn R. and Knopfel T. (1996) Cellular localisation of metabotropic glutamate receptors in the mammalian optic nerve: a mechanism for axon-glia communication. Brain Res. 741, 75-81.
17. John S. W. M., Hagaman J. R., MacTaggart T. E., Peng L. and Smithes O. (1997) Intraocular pressure in inbred mouse strains. Invest. Ophthalmol. Vis Sci. 38, 249-253.
18. John S. W., Smith R. S., Savinova O. V., Hawes N. L., Chang B., Tumbull D., Davisson M., Roderick T. H. and Heckenlively J. R. (1998) Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest. Ophthalmol. Vis. Sci. 39, 951-962.
19. Koulen P. and Brandstätter J. H. (2002) Pre- and post-synaptic sites of action of mGluR8a in the mammalian retina. Invest. Ophthalmol. Vis. Sci. 43, 1933-1940.
20. Koulen P., Kuhn R., Wässle H. and Brandstätter J. H. (1997) Group 1 metabotropic glutamate receptors mGluR1α and mGluR5a: localization in both synaptic layers of the rat retina. J. Neurosci. 17, 2200-2211.
21. Kreutz M. R., Bockers T. M., Bockmann J., Seidenbecher C. I., Kracht B., Vorwerk C. K., Weise J. and Sabel B. A. (1998) Axonal injury alters alternative splicing of the retinal NR1 receptor: the preferential expression of the NR1b isoforms is crucial for retinal ganglion cell survival. J. Neurosci. 18, 8278-8291.
22. Krishnamoorthy R. R., Agarwal P., Prasanna G. et al. (2001) Characterization of a transformed rat retinal ganglion cell line. Brain Res. Mol. Brain Res. 86, 1-12.
23. Kwong J. M. and Lam T. T. (2000) N-methyl-D-aspartate (NMDA) induced apoptosis in adult rabbit retinas. Exp. Eye Res. 71, 437-444.
24. Lam T. T., Abler A. S., Kwong J. M. and Tso M. O. (1999) N-methyl-D-aspartate (NMDA)-induced apoptosis in rat retina. Invest. Ophthalmol. Vis. Sci. 40, 2391-2397.
25. Liu B. and Neufeld A. H. (2001) Nitric oxide synthase-2 in human optic nerve head astrocytes induced by elevated pressure in vitro. Arch. Ophthalmol. 119, 240-245.
26. Masu M., Iwakabe H., Tagawa Y. et al. (1995) Specific deficit of the ON response in visual transmission by targeted disruption of the mGLuR6 gene. Cell 80, 757-765.
27. Morgan J. E. (2000) Optic nerve head structure in glaucoma: astrocytes as mediators of axonal damage. Eye 14, 437-444.
28. Nakanishi S., Nakajima Y., Masu M., Ueda Y., Nakahara K., Watanabe D., Yamaguchi S., Kawabata S. and Okada M. (1998) Glutamate receptors: brain function and signal transduction. Brain Res. Brain Res. Rev. 26, 230-235.
29. Naskar R., Vorwerk C. K. and Dreyer E. B. (2000) Concurrent down-regulation of a glutamate transporter and receptor in glaucoma. Invest. Ophthalmol. Vis. Sci. 41, 1940-1944.
30. Otori Y., Wei J. Y. and Barnstable C. J. (1998) Neurotoxic effects of low doses of glutamate on purified rat retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 39, 972-981.
31. Park K. H., Cozier F., Ong O. C. and Caprioli J. (2001) Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 42, 1522-1530.
32. Pease M. E., McKinnon S. J., Quigley H. A., Kerrigan-Baumrind L. A. and Zack D. J. (2000) Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 41, 764-774.
33. Piehl F., Tabar G. and Cullheim S. (1995) Expression of NMDA receptor mRNAs in rat motoneurons is downregulated after axotomy. Eur. J. Neurosci. 7, 2101-2110.
34. Pin J. P. and Duvoisin R. (1995) Neurotransmitter receptors. 1. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34, 1-26.
35. Quigley H. A., McKinnon S. J., Zack D. J., Pease M. E., Kerrigan-Baumrind L. A., Kerrigan D. F. and Mitchell R. S. (2000) Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest. Ophthalmol. Vis. Sci. 41, 3460-3466.
36. Salvador-Silva M., Ricard C. S., Agapova O. A., Yang P. and Hernandez M. R. (2001) Expression of small heat shock proteins and intermediate filaments in the human optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro. J. Neurosci. Res. 66, 59-73.
37. Samarasinghe S., Virgo L. and de Belleroche J. (1996) Distribution of the N-methyl-D-aspartate glutamate receptor subunit NR2A in control and amyotrophic lateral sclerosis spinal cord. Brain Res. 727, 233-237.
38. Savinova O. V., Sugiyama F., Martin J. E., Tomarev S. I., Paigen B. J., Smith R. S. and John S. W. (2001) Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet. 2, 12.
39. Schori H., Kipnis J., Yoles E., WoldeMussie E., Ruiz G., Wheeler L. A. and Schwartz M. (2001) Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Proc. Natl Acad. Sci. USA 98, 3398-3403.
40. Schuettauf F., Quinto K., Naskar R. and Zurakowski D. (2002) Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model. Vision Res. 42, 2333-2337.
41. Schuettauf F., Rejdak R., Walski M., Frontczak-Baniewicz M., Voelker M., Blatsios G., Shinoda K., Zagorski Z., Zrenner E. and Grieb P. (2004) Retinal neurodegeneration in the DBA/2J mouse-a model for ocular hypertension. Acta Neuropathol. 107, 352-358.
42. Sheng M. (2001) Molecular organization of the post-synaptic specialization. Proc. Natl Acad. Sci. USA 98, 7058-7061.
43. Stoilov I. R., Costa V. P., Vasconcellos J. P., Melo M. B., Betinjane A. J., Carani J. C., Oltrogge E. V. and Sarfarazi M. (2002) Molecular genetics of primary congenital glaucoma in Brazil. Invest. Ophthalmol. Vis. Sci. 43, 1820-1827.
44. Stone E. M., Fingert J. H., Alward W. L. et al. (1997) Identification of a gene that causes primary open-angle glaucoma. Science 275, 668-670.
45. Surgucheva I., McMahan B., Ahmed F., Tomarev S., Wax M. B. and Surguchov A. (2002) Synucleins in glaucoma: implication of γ-synuclein in glaucomatous alterations in the optic nerve. J. Neurosci. Res. 68, 97-106.
46. Tehrani A., Wheeler-Schilling T. H. and Guenther E. (2000) Coexpression patterns of mGLuR mRNAs in rat retinal ganglion cells: a single-cell RT-PCR study. Invest. Ophthalmol. Vis. Sci. 41, 314-319.
47. Tezel G., Hernandez R. and Wax M. B. (2000) Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch. Ophthalmol. 118, 511-518.
48. Vardi N., Duvoisin R., Wu G. and Sterling P. (2000) Localisation of mGluR6 to dendrites of ON bipolar cells in primate retina. J. Comp. Neurol. 423, 402-412.
49. Vincent A. L., Billingsley G., Buys Y., Levin A. V., Priston M., Trope G., Williams-Lyn D. and Heon E. (2002) Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene. Am. J. Hum. Genet. 70, 448-460.
50. Vorwerk C. K., Lipton S. A., Zurakowski D., Hyman B. T., Sabel B. A. and Dreyer E. B. (1996) Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine. Invest. Ophthalmol. Vis. Sci. 37, 1618-1624.
51. Vorwerk C. K., Naskar R., Schuettauf F., Quinto K., Zurakowski D., Gochenauer G., Robinson M. B., Mackler S. A. and Dreyer E. B. (2000) Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death. Invest. Ophthalmol. Vis. Sci. 41, 3615-3621.