Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: Design, synthesis and in vitro pharmacological activity

Journal of Peptide Research

Volumn 63, Issue 6, 2004, Pages 477-484

  Guerrini, R ^a   Carra', G ^a   Calo', G ^a,b   Trapella, C ^a   Marzola, E ^a   Rizzi, D ^a   Regoli, D ^a   Salvadori, S ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b Section of Pharmacology   (Italy)

Author keywords

(8 Naphthalen 1 yl methyl 4 oxo 1 phenyl 1,3,8 triaza spiro 4,5 dec 3 yl) aceticacid methyl ester; Guinea pig ileum; Nociceptin orphanin FQ; Nociceptin orphanin FQ peptide and opioid receptors

Indexed keywords

(8 NAPHTHALEN 1 YLMETHYL 4 OXO 1 PHENYL 1,3,8 TRIAZASPIRO[4,5]DEC 3 YL)ACETIC ACID METHYL ESTER; [8 (1 NAPHTHYLMETHYL) 4 OXO 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DEC 3 YL]ACETIC ACID METHYL ESTER; CHIMERIC PROTEIN; ESTER DERIVATIVE; NALOXONE; NOCICEPTIN; NOCICEPTIN RECEPTOR; THREONINAMIDE; THREONYLGLYCYLALANYLARGINYLLYSINAMIDE; THREONYLGLYCYLALANYLARGINYLLYSYLSERYLALANYLARGINYLLYSINAMIDE; THREONYLGLYCYLALANYLARGINYLLYSYLSERYLALANYLARGINYLLYSYLLEUCYLALANYLASPARAGI NYLGLUTAMINAMIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ELECTROSTIMULATION; GUINEA PIG; ILEUM; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SYNTHESIS;

ACETIC ACIDS; AMINO ACID SEQUENCE; ANIMALS; DRUG DESIGN; GUINEA PIGS; ILEUM; LIGANDS; MALE; MOLECULAR SEQUENCE DATA; NALOXONE; OPIOID PEPTIDES; PEPTIDE FRAGMENTS; RECEPTORS, OPIOID; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 3042687618     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2004.00157.x     Document Type: Article

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