Micafungin enhances neutrophil fungicidal functions against Candida pseudohyphae

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 7, 2004, Pages 2730-2732

  Gil Lamaignere, Cristina ^a   Salvenmoser, Stefanie ^a   Hess, Regina ^a   Müller, Frank Michael C ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Pediat Pulmonology and Infect Dis   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MICAFUNGIN; SUPEROXIDE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; CANDIDA ALBICANS; CANDIDA DUBLINIENSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; DRUG SCREENING; FUNGAL STRAIN; FUNGUS HYPHAE; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY BURST;

CANDIDA; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; HYPHAE; LIPOPROTEINS; NEUTROPHILS; PEPTIDES, CYCLIC; PHAGOCYTOSIS; RESPIRATORY BURST; STIMULATION, CHEMICAL; SUPEROXIDES;

EID: 3042677856     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.7.2730-2732.2004     Document Type: Article

References (10)

1. Abu, J. L., R. Haidar, F. Bitar, S. Mroueh, S. Akel, N. Nuwayri-Salti, and G. S. Dbaibo. 2000. Aspergillus vertebral osteomyelitis in a child with a primary monocyte killing defect: response to GM-CSF therapy. J. Infect. 41:97-100.
2. Gaviria, J. M., J. A. van Burik, D. C. Dale, R. K. Root, and W. C. Liles. 1999. Comparison of interferon-gamma, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor for priming leukocyte-mediated hyphal damage of opportunistic fungal pathogens. J. Infect. Dis. 179:1038-1041.
3. Gil-Lamaignere, C., E. Roilides, C. A. Lyman, M. Simitsopoulou, T. Stergiopoulou, A. Maloukou, and T. J. Walsh. 2003. Human phagocytic cell responses to Scedosporium apiospermum (Pseudallescheria boydii): variable susceptibility to oxidative injury. Infect. Immun. 71:6472-6478.
4. Gil-Lamaignere, C., E. Roilides, J. Mosquera, A. Maloukou, and T. J. Walsh. 2002. Antifungal triazoles and polymorphonuclear leukocytes synergize to cause increased hyphal damage to Scedosporium prolificans and Scedosporium apiospermum. Antimicrob. Agents Chemother. 46:2234-2237.
5. Gurer, U. S., A. Cevikbas, C. Johansson, K. Derici, and T. Yardimci. 1999. Effect of fluconazole on human polymorphonuclear leucocyte functions ex vivo against Candida albicans. Chemotherapy 45:277-283.
6. Hwang, C. S., G. E. Rhie, J. H. Oh, W. K. Huh, H. S. Yim, and S. O. Kang. 2002. Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence. Microbiology 148:3705-3713.
7. Kuijpers, T. W., R. S. Weening, and D. Roos. 1999. Clinical and laboratory work-up of patients with neutrophil shortage or dysfunction. J. Immunol. Methods 232:211-229.
8. Liu, W., M. S. Lionakis, R. E. Lewis, N. Wiederhold, G. S. May, and D. P. Kontoyiannis. 2003. Attenuation of itraconazole fungicidal activity following preexposure of Aspergillus fumigatus to fluconazole. Antimicrob. Agents Chemother. 47:3592-3597.
9. Richard, M., S. Ibata-Ombetta, F. Dromer, F. Bordon-Pallier, T. Jouault, and C. Gaillardin. 2002. Complete glycosylphosphatidylinositol anchors are required in Candida albicans for full morphogenesis, virulence and resistance to macrophages. Mol. Microbiol. 44:841-853.
10. Sullivan, D. J., G. P. Moran, E. Pinjon, A. Al-Mosaid, C. Stokes, C. Vaughan, and D. C. Coleman. 2004. Comparison of the epidemiology, drug resistance mechanisms, and virulence of Candida dubliniensis and Candida albicans. FEMS Yeast Res. 4:369-376.