Genetic polymorphism of the accessory gene regulator (agr) locus in Staphylococcus epidermidis and its association with pathogenicity

Journal of Medical Microbiology

Volumn 53, Issue 6, 2004, Pages 545-549

  Li, M ^a   Guan, M ^a   Jiang, X F ^a   Yuan, F Y ^a   Xu, M ^a   Zhang, W Z ^a   Lu, Y ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BLOOD; CATHETER; CHINA; GENE AMPLIFICATION; GENE CONTROL; GENE LOCUS; GENE MUTATION; GENETIC POLYMORPHISM; HOSPITAL; NONHUMAN; PATHOGENICITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STAPHYLOCOCCUS EPIDERMIDIS; STATISTICAL SIGNIFICANCE;

BACTERIAL PROTEINS; CATHETERS, INDWELLING; CHINA; GENES, BACTERIAL; HOSPITALS; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS; TRANS-ACTIVATORS; VIRULENCE;

EID: 3042664553     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.05406-0     Document Type: Article

References (32)

1. Abdelnour, A., Arvidson, S., Bremell, T., Ryden, C. & Tarkowski, A. (1993). The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect Immun 61, 3879-3885.
2. Aiyar, A. (2000). The use of CLUSTAL W and CLUSTAL X for multiple sequence alignment. Methods Mol Biol 132, 221-241.
3. Ammendolia, M. G., Di Rosa, R., Montanaro, L., Arciola, C. R. & Baldassarri, L. (1999). Slime production and expression of the slime-associated antigen by staphylococcal clinical isolates. J Clin Microbiol 37, 3235-3238.
4. Caputo, G. M., Archer, G. L., Calderwood, S. B., DiNubile, M. J. & Karchmer, A. W. (1987). Native valve endocarditis due to coagulase-negative staphylococci: clinical and microbiologic features. Am J Med 83, 619-625.
5. Christensen, G. D., Simpson, W. A., Younger, J. J., Baddour, L. M., Barrett, F. F., Melton, D. M. & Beachey, E. H. (1985). Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J Clin Microbiol 22, 996-1006.
6. Day, N. P., Moore, C. E., Enright, M. C., Berendt, A. R., Smith, J. M., Murphy, M. F., Peacock, S. J., Spratt, B. G. & Feil, E. J. (2001). A link between virulence and ecological abundance in natural populations of Staphylococcus aureus. Science 292, 114-116.
7. Dufour, P., Jarraud, S., Vandenesch, F., Greenland, T., Novick, R. P., Bes, M., Etienne, J. & Lina, G. (2002). High genetic variability of the agr locus in Staphylococcus species. J Bacteriol 184, 1180-1186.
8. Heilmann, C., Hussain, M., Peters, G. & Götz, F. (1997). Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface. Mol Microbiol 24, 1013-1024.
9. Hoyle, B. D. & Costerton, J. W. (1991). Bacterial resistance to antibiotics: the role of biofilms. Prog Drug Res 37, 91-105.
10. Huebner, J. & Goldmann, D. A. (1999). Coagulase-negative staphylococci: role as pathogens. Annu Rev Med 50, 223-236.
11. Jarraud, S., Lyon, G. J., Figueiredo, A. M., Gerard, L., Vandenesch, F., Etienne, J., Muir, T. W. & Novick, R. P. (2000). Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. J Bacteriol 182, 6517-6522.
12. Jarraud, S., Mougel, C., Thioulouse, J., Lina, G., Meugnier, H., Forey, F., Nesme, X., Etienne, J. & Vandenesch, F. (2002). Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect Immun 70, 631-641.
13. Ji, G., Beavis, R. & Novick, R. P. (1997). Bacterial interference caused by autoinducing peptide variants. Science 276, 2027-2030.
14. Lina, G., Boutite, F., Tristan, A., Bes, M., Etienne, J. & Vandenesch, F. (2003). Bacterial competition for human nasal cavity colonization: role of staphylococcal agr alleles. Appl Environ Microbiol 69, 18-23.
15. Mah, T. F. & O'Toole, G. A. (2001). Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 9, 34-39.
16. Moore, P. C. & Lindsay, J. A. (2001). Genetic variation among hospital isolates of methicillin-sensitive Staphylococcus aureus: evidence for horizontal transfer of virulence genes. J Clin Microbiol 39, 2760-2767.
17. Novick, R. P. & Muir, T. W. (1999). Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria. Curr Opin Microbiol 2, 40-45.
18. O'Gara, J. P. & Humphreys, H. (2001). Staphylococcus epidermidis biofilms: importance and implications. J Med Microbiol 50, 582-587.
19. Otto, M. (2001). Staphylococcus aureus and Staphylococcus epidermidis peptide pheromones produced by the accessory gene regulator agr system. Peptides 22, 1603-1608.
20. Otto, M., Süssmuth, R., Jung, G. & Götz, F. (1998). Structure of the pheromone peptide of the Staphylococcus epidermidis agr system. FEBS Lett 424, 89-94.
21. Otto, M., Süssmuth, R., Vuong, C., Jung, G. & Götz, F. (1999). Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives. FEBS Lett 450, 257-262.
22. Otto, M., Echner, H., Voelter, W. & Götz, F. (2001). Pheromone cross-inhibition between Staphylococcus aureus and Staphylococcus epidermidis. Infect Immun 69, 1957-1960.
23. Papakyriacou, H., Vaz, D., Simor, A., Louie, M. & McGavin, M. J. (2000). Molecular analysis of the accessory gene regulator (agr) locus and balance of virulence factor expression in epidemic methicillin-resistant Staphylococcus aureus. J Infect Dis 181, 990-1000.
24. Peschel, A., Otto, M., Jack, R. W., Kalbacher, H., Jung, G. & Götz, F. (1999). Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. J Biol Chem 274, 8405-8410.
25. Petinaki, E., Arvaniti, A., Dimitracopoulos, G. & Spiliopoulou, I. (2001). Detection of mecA, mecR1 and mecI genes among clinical isolates of methicillin-resistant staphylococci by combined polymerase chain reactions. J Antimicrob Chemother 47, 297-304.
26. Raad, I., Alrahwan, A. & Rolston, K. (1998). Staphylococcus epidermidis: emerging resistance and need for alternative agents. Clin Infect Dis 26, 1182-1187.
27. Recsei, P., Kreiswirth, B., O'Reilly, M., Schlievert, P., Gruss, A. & Novick, R. P. (1986). Regulation of exoprotein gene expression in Staphylococcus aureus by agr. Mol Gen Genet 202, 58-61.
28. von Eiff, C., Peters, G. & Heilmann, C. (2002). Pathogenesis of infections due to coagulase-negative staphylococci. Lancet Infect Dis 2, 677-685.
29. Vuong, C. & Otto, M. (2002). Staphylococcus epidermidis infections. Microbes Infect 4, 481-489.
30. Vuong, C., Götz, F. & Otto, M. (2000a). Construction and characterization of an agr deletion mutant of Staphylococcus epidermidis. Infect Immun 68, 1048-1053.
31. Vuong, C., Saenz, H. L., Götz, F. & Otto, M. (2000b). Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis 182, 1688-1693.
32. Vuong, C., Gerke, C., Somerville, G. A., Fischer, E. R. & Otto, M. (2003). Quorum-sensing control of biofilm factors in Staphylococcus epidermidis. J Infect Dis 188, 706-718.