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Volumn 2, Issue 1, 1999, Pages 40-45

Virulence gene regulation by peptides in staphylococci and other gram- positive bacteria

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; BACTERIAL PROTEIN; DNA; HEMOLYSIN; PEPTIDE; PHEROMONE; REGULATOR PROTEIN; RNA; VIRULENCE FACTOR;

EID: 0033057730     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(99)80007-1     Document Type: Article
Times cited : (134)

References (36)
  • 1
    • 0028944117 scopus 로고
    • Autocrine regulation of toxin synthesis by Staphylococcus aureus
    • Balaban N, Novick RP Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci USA. 92:1995;1619-1623.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1619-1623
    • Balaban, N.1    Novick, R.P.2
  • 2
    • 0029558610 scopus 로고
    • Cell density control of staphylococcal virulence mediated by an octapeptide pheromone
    • Ji G, Beavis R, Novick R Cell density control of staphylococcal virulence mediated by an octapeptide pheromone. Proc Natl Acad Sci USA. 92:1995;12055-12059.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12055-12059
    • Ji, G.1    Beavis, R.2    Novick, R.3
  • 3
    • 0028284877 scopus 로고
    • Biochemical and genetic characterization of a competence pheromone from B. subtilis
    • Magnuson R, Solomon J, Grossman AD Biochemical and genetic characterization of a competence pheromone from B. subtilis. Cell. 77:1994;207-216.
    • (1994) Cell , vol.77 , pp. 207-216
    • Magnuson, R.1    Solomon, J.2    Grossman, A.D.3
  • 4
    • 0028951976 scopus 로고
    • Convergent sensing pathways mediate response to two extracellular competence factors in Bacillus subtilis
    • Solomon J, Magnuson R, Sruvastavam A, Grossman A Convergent sensing pathways mediate response to two extracellular competence factors in Bacillus subtilis. Genes Dev. 9:1995;547-558.
    • (1995) Genes Dev , vol.9 , pp. 547-558
    • Solomon, J.1    Magnuson, R.2    Sruvastavam, A.3    Grossman, A.4
  • 5
    • 0029745349 scopus 로고    scopus 로고
    • Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system
    • Morrison D, Pestova E, Havarstein L Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system. Mol Microbiol. 21:1996;853-862.
    • (1996) Mol Microbiol , vol.21 , pp. 853-862
    • Morrison, D.1    Pestova, E.2    Havarstein, L.3
  • 6
    • 0028845364 scopus 로고
    • An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae
    • Havarstein LS, Coomaraswamy G, Morrison DA An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae. Proc Natl Acad Sci USA. 92:1995;11140-11144.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11140-11144
    • Havarstein, L.S.1    Coomaraswamy, G.2    Morrison, D.A.3
  • 7
    • 0029818809 scopus 로고    scopus 로고
    • Census and consensus in bacterial ecosystems: The LuxR-LuxI family of quorum-sensing transcriptional regulators
    • Fuqua C, Winans SC, Greenberg EP Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators. Annu Rev Microbiol. 50:1996;727-751.
    • (1996) Annu Rev Microbiol , vol.50 , pp. 727-751
    • Fuqua, C.1    Winans, S.C.2    Greenberg, E.P.3
  • 9
    • 0001432933 scopus 로고
    • Genetic studies of virulence factors of Staphylococcus aureus. Properties of coagulase and gamma-toxin, alpha-toxin, beta-toxin and protein A in the pathogenesis of S. aureus infections
    • R.P. Novick. New York: VCH Publishers
    • Foster TJ, O'Reilly M, Phonimdaeng P, Cooney J, Patel AH, Bramley AJ Genetic studies of virulence factors of Staphylococcus aureus. Properties of coagulase and gamma-toxin, alpha-toxin, beta-toxin and protein A in the pathogenesis of S. aureus infections. Novick RP Molecular Biology of the Staphylococci. 1990;403-420 VCH Publishers, New York.
    • (1990) Molecular Biology of the Staphylococci , pp. 403-420
    • Foster, T.J.1    O'Reilly, M.2    Phonimdaeng, P.3    Cooney, J.4    Patel, A.H.5    Bramley, A.J.6
  • 10
    • 0026633880 scopus 로고
    • Murine model of cutaneous infection with gram-positive cocci
    • Barg N, Bunce C, Wheeler L, Reed G, Musser J Murine model of cutaneous infection with gram-positive cocci. Infect Immun. 60:1992;2636-2640.
    • (1992) Infect Immun , vol.60 , pp. 2636-2640
    • Barg, N.1    Bunce, C.2    Wheeler, L.3    Reed, G.4    Musser, J.5
  • 11
    • 0027169704 scopus 로고
    • The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model
    • Abdelinour A, Arvidson S, Bremell T, Ryden C, Tarkowski A The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect Immun. 61:1993;3879-3885.
    • (1993) Infect Immun , vol.61 , pp. 3879-3885
    • Abdelinour, A.1    Arvidson, S.2    Bremell, T.3    Ryden, C.4    Tarkowski, A.5
  • 12
    • 0023807526 scopus 로고
    • Cloning, characterization and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus
    • Peng H-L, Novick RP, Kreiswirth B, Kornblum J, Schlievert P Cloning, characterization and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus. J Bacteriol. 179:1988;4365-4372.
    • (1988) J Bacteriol , vol.179 , pp. 4365-4372
    • Peng, H.-L.1    Novick, R.P.2    Kreiswirth, B.3    Kornblum, J.4    Schlievert, P.5
  • 13
    • 0027180031 scopus 로고
    • Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule
    • Novick RP, Ross HF, Projan SJ, Kornblum J, Kreiswirth B, Moghazeh S Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J. 12:1993;3967-3975.
    • (1993) EMBO J , vol.12 , pp. 3967-3975
    • Novick, R.P.1    Ross, H.F.2    Projan, S.J.3    Kornblum, J.4    Kreiswirth, B.5    Moghazeh, S.6
  • 14
    • 0001639009 scopus 로고
    • Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus
    • Lofdahl S, Morfeldt E, Janzon L, Arvidson S Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus. Mol Gen Genet. 211:1988;435-440.
    • (1988) Mol Gen Genet , vol.211 , pp. 435-440
    • Lofdahl, S.1    Morfeldt, E.2    Janzon, L.3    Arvidson, S.4
  • 15
    • 0013686223 scopus 로고
    • The role of the delta-lysin gene (hld) in the agr-dependent regulation of exoprotein synthesis in Staphylococcus aureus
    • R.P. Novick. New York: VCH Publishers
    • Arvidson S, Janzon L, Lofdahl S The role of the delta-lysin gene (hld) in the agr-dependent regulation of exoprotein synthesis in Staphylococcus aureus. Novick RP Molecular Biology of the Staphylococci. 1990;421-432 VCH Publishers, New York.
    • (1990) Molecular Biology of the Staphylococci , pp. 421-432
    • Arvidson, S.1    Janzon, L.2    Lofdahl, S.3
  • 16
    • 0002014616 scopus 로고
    • Agr: A polycistronic locus regulating exoprotein synthesis in Staphylococcus aureus
    • R.P. Novick. New York: VCH Publishers
    • Kornblum J, Kreiswirth B, Projan SJ, Ross H, Novick RP Agr: a polycistronic locus regulating exoprotein synthesis in Staphylococcus aureus. Novick RP Molecular Biology of the Staphylococci. 1990;373-402 VCH Publishers, New York.
    • (1990) Molecular Biology of the Staphylococci , pp. 373-402
    • Kornblum, J.1    Kreiswirth, B.2    Projan, S.J.3    Ross, H.4    Novick, R.P.5
  • 17
    • 0029085646 scopus 로고
    • The agr P-2 operon: An autocatalytic sensory transduction system in Staphylococcus aureus
    • Novick RP, Projan S, Kornblum J, Ross H, Kreiswirth B, Moghazeh S The agr P-2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus. Mol Gen Genet. 248:1995;446-458.
    • (1995) Mol Gen Genet , vol.248 , pp. 446-458
    • Novick, R.P.1    Projan, S.2    Kornblum, J.3    Ross, H.4    Kreiswirth, B.5    Moghazeh, S.6
  • 18
    • 0030271449 scopus 로고    scopus 로고
    • Detection of the response regulator AgrA in the cytosolic fraction of Staphylococcus aureus by monoclonal antibodies
    • Morfeldt E, Panova-Sapundjieva I, Gustafsson B, Arvidson S Detection of the response regulator AgrA in the cytosolic fraction of Staphylococcus aureus by monoclonal antibodies. FEMS Microbiol Lett. 143:1996;195-201.
    • (1996) FEMS Microbiol Lett , vol.143 , pp. 195-201
    • Morfeldt, E.1    Panova-Sapundjieva, I.2    Gustafsson, B.3    Arvidson, S.4
  • 19
    • 0030838740 scopus 로고    scopus 로고
    • Bacterial interference caused by autoinducing peptide variants
    • This paper contains two key findings: the subclassification of S. aureus on the basis of autoinducing peptide specificity, demonstrating cross-inhibition between groups by means of an agr-blaZ fusion, and preliminary results demonstrating the cyclic thiolactone structure for the peptides.
    • Ji G, Beavis R, Novick RP Bacterial interference caused by autoinducing peptide variants. Science. 276:1997;2027-2030. This paper contains two key findings: the subclassification of S. aureus on the basis of autoinducing peptide specificity, demonstrating cross-inhibition between groups by means of an agr-blaZ fusion, and preliminary results demonstrating the cyclic thiolactone structure for the peptides.
    • (1997) Science , vol.276 , pp. 2027-2030
    • Ji, G.1    Beavis, R.2    Novick, R.P.3
  • 20
    • 0031959577 scopus 로고    scopus 로고
    • Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus
    • The membership of AgrC in the class of bacterial transmembrane signal receptors was predicted from its sequence and is confirmed here by a demmonstration of its phosphorylation in response to the activating peptide and of the expected external and internal loops by means of PhoA fusions. A surprising result is that only the last extracellular domain seems to be required for activation.
    • Lina G, Jarraud S, Ji G, Greenland T, Pedraza A, Etienne J, Novick RP, Vandenesch F Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus. Mol Microbiol. 28:1998;655-662. The membership of AgrC in the class of bacterial transmembrane signal receptors was predicted from its sequence and is confirmed here by a demmonstration of its phosphorylation in response to the activating peptide and of the expected external and internal loops by means of PhoA fusions. A surprising result is that only the last extracellular domain seems to be required for activation.
    • (1998) Mol Microbiol , vol.28 , pp. 655-662
    • Lina, G.1    Jarraud, S.2    Ji, G.3    Greenland, T.4    Pedraza, A.5    Etienne, J.6    Novick, R.P.7    Vandenesch, F.8
  • 21
  • 22
    • 0029814352 scopus 로고    scopus 로고
    • Transcriptional control of the agr-dependent virulence gene regulator
    • Morfeldt E, Tegmark K, Arvidson S Transcriptional control of the agr-dependent virulence gene regulator. Mol Microbiol. 21:1996;1227-1237.
    • (1996) Mol Microbiol , vol.21 , pp. 1227-1237
    • Morfeldt, E.1    Tegmark, K.2    Arvidson, S.3
  • 23
    • 0028300672 scopus 로고
    • Coagulase deficiency in clinical isolates of Staphylococcus aureus involves both transcriptional and post-transcriptional defects
    • Vandenesch F, Lebeau C, Bes M, McDevitt D, Greenland T, Novick RP, Etienne C Coagulase deficiency in clinical isolates of Staphylococcus aureus involves both transcriptional and post-transcriptional defects. J Med Microbiol. 40:1994;344-349.
    • (1994) J Med Microbiol , vol.40 , pp. 344-349
    • Vandenesch, F.1    Lebeau, C.2    Bes, M.3    McDevitt, D.4    Greenland, T.5    Novick, R.P.6    Etienne, C.7
  • 24
    • 0029113833 scopus 로고
    • Activation of alpha-toxin translation in Staphylococcus aureus by the trans-encoded antisense RNA, RNAIII
    • Morfeldt E, Taylor D, von Gabain A, Arvidson S Activation of alpha-toxin translation in Staphylococcus aureus by the trans-encoded antisense RNA, RNAIII. EMBO J. 14:1995;4569-4577.
    • (1995) EMBO J , vol.14 , pp. 4569-4577
    • Morfeldt, E.1    Taylor, D.2    Von Gabain, A.3    Arvidson, S.4
  • 25
    • 0032584653 scopus 로고    scopus 로고
    • Concerted evolution in an egg receptor for a rapidly evolving abalone sperm protein
    • This paper presents a biological rationale for the co-evolution of interacting gamete proteins and shows how this may be a key process in speciation. There may be an interesting parallel here in the concerted evolution of the specificity determinants of peptide and receptor within the agr locus, which could conceivably represent incipient speciation in the staphylococci.
    • Swanson WJ, Vacquier VD Concerted evolution in an egg receptor for a rapidly evolving abalone sperm protein. Science. 281:1998;710-712. This paper presents a biological rationale for the co-evolution of interacting gamete proteins and shows how this may be a key process in speciation. There may be an interesting parallel here in the concerted evolution of the specificity determinants of peptide and receptor within the agr locus, which could conceivably represent incipient speciation in the staphylococci.
    • (1998) Science , vol.281 , pp. 710-712
    • Swanson, W.J.1    Vacquier, V.D.2
  • 26
    • 0032489489 scopus 로고    scopus 로고
    • Structure of the pheromone peptide of the Staphylococcus epidermidis agr system
    • The agr system is conserved throughout the staphylococci, though in non-aureus species its activation by culture supernatants is rather weak, at best. Nevertheless, the autoinducing peptides of S. epidermidis are confirmed to possess the same cyclic thiolactone structure as those of S. aureus. Given that non-aureus staphylococci generally do not express the set of S. aureus virulence factors, there has yet to be a demonstration that agr actually regulates anything in these other species. In failing to address this issue, this paper leaves much to be desired.
    • Otto M, Sussmuth R, Jung G, Gotz F Structure of the pheromone peptide of the Staphylococcus epidermidis agr system. FEBS Lett. 424:1998;89-94. The agr system is conserved throughout the staphylococci, though in non-aureus species its activation by culture supernatants is rather weak, at best. Nevertheless, the autoinducing peptides of S. epidermidis are confirmed to possess the same cyclic thiolactone structure as those of S. aureus. Given that non-aureus staphylococci generally do not express the set of S. aureus virulence factors, there has yet to be a demonstration that agr actually regulates anything in these other species. In failing to address this issue, this paper leaves much to be desired.
    • (1998) FEBS Lett , vol.424 , pp. 89-94
    • Otto, M.1    Sussmuth, R.2    Jung, G.3    Gotz, F.4
  • 27
    • 85030357539 scopus 로고    scopus 로고
    • Structure-activity analysis of the thiolactone peptides from Staphylococcus aureus responsible for autoinduction of virulence and for bacterial interference
    • in press. This paper describes an elegant solid-phase method for the synthesis of cyclic thiolactone peptides, finalizing the proof of this structure for the autoinducing peptides of S. aureus, and permitting the rapid synthesis of a large number of variants. Study of these suggests that the thiolactone structure is essential for activation but not for inhibition, that the activating peptide forms a covalent bond with its receptor and that inhibitory peptides bind to the receptor differently than activators. It also demonstrates that an inhibitory peptide can attenuate an experimental staphylococcal infection.
    • Mayville P, Ji G, Beavis R, Yang H-M, Goger M, Novick RP, Muir TW Structure-activity analysis of the thiolactone peptides from Staphylococcus aureus responsible for autoinduction of virulence and for bacterial interference. Proc Natl Acad Sci USA. 1999;. in press. This paper describes an elegant solid-phase method for the synthesis of cyclic thiolactone peptides, finalizing the proof of this structure for the autoinducing peptides of S. aureus, and permitting the rapid synthesis of a large number of variants. Study of these suggests that the thiolactone structure is essential for activation but not for inhibition, that the activating peptide forms a covalent bond with its receptor and that inhibitory peptides bind to the receptor differently than activators. It also demonstrates that an inhibitory peptide can attenuate an experimental staphylococcal infection.
    • (1999) Proc Natl Acad Sci USA
    • Mayville, P.1    Ji, G.2    Beavis, R.3    Yang, H.-M.4    Goger, M.5    Novick, R.P.6    Muir, T.W.7
  • 29
    • 0029013783 scopus 로고
    • A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export
    • Havarstein LS, Diep DB, Nes IF A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export. Mol Microbiol. 16:1995;229-240.
    • (1995) Mol Microbiol , vol.16 , pp. 229-240
    • Havarstein, L.S.1    Diep, D.B.2    Nes, I.F.3
  • 30
    • 7144229375 scopus 로고    scopus 로고
    • A competence regulon in Streptococcus pneumoniae revealed by genomic analysis
    • This is an elegant demonstration of how genomic analysis can be used to identify a family of coregulated genes and operons: a conserved regulatory motif turns out to represent a family of genes that are coregulated by the competence-inducing system and are involved in DNA uptake and processing.
    • Campbell EA, Choi SY, Masure HR A competence regulon in Streptococcus pneumoniae revealed by genomic analysis. Mol Microbiol. 27:1998;929-939. This is an elegant demonstration of how genomic analysis can be used to identify a family of coregulated genes and operons: a conserved regulatory motif turns out to represent a family of genes that are coregulated by the competence-inducing system and are involved in DNA uptake and processing.
    • (1998) Mol Microbiol , vol.27 , pp. 929-939
    • Campbell, E.A.1    Choi, S.Y.2    Masure, H.R.3
  • 31
    • 0031962031 scopus 로고    scopus 로고
    • Competence-specific induction of recA is required for full recombination proficiency during transformation in Streptococcus pneumoniae
    • The Com-induced recA operon also contains lytA, an autolysin gene that is required for virulence as well as for competence, thus linking these two apparently disparate capabilities and also demonstrating autoinduction of virulence by a density-sensing peptide.
    • Mortier-Barriere I, de Saizieu A, Claverys JP, Martin B Competence-specific induction of recA is required for full recombination proficiency during transformation in Streptococcus pneumoniae. Mol Microbiol. 27:1998;159-170. The Com-induced recA operon also contains lytA, an autolysin gene that is required for virulence as well as for competence, thus linking these two apparently disparate capabilities and also demonstrating autoinduction of virulence by a density-sensing peptide.
    • (1998) Mol Microbiol , vol.27 , pp. 159-170
    • Mortier-Barriere, I.1    De Saizieu, A.2    Claverys, J.P.3    Martin, B.4
  • 32
    • 0024322485 scopus 로고
    • Contribution of autolysin to virulence of Streptococcus pneumoniae
    • Berry AM, Lock RA, Hansman D, Paton JC Contribution of autolysin to virulence of Streptococcus pneumoniae. Infect Immun. 57:1989;2324-2330.
    • (1989) Infect Immun , vol.57 , pp. 2324-2330
    • Berry, A.M.1    Lock, R.A.2    Hansman, D.3    Paton, J.C.4
  • 33
    • 0030792814 scopus 로고    scopus 로고
    • Cell-cell communication in gram-positive bacteria
    • This is an excellent review of peptide-based global regulation, focusing on the mating pheromones of enterococci, which are different from most of the regulatory peptides in Gram-positive bacteria in that they do not represent ligands for signal receptors, nor do they represent density sensors.
    • Dunny GM, Leonard BA Cell-cell communication in gram-positive bacteria. Annu Rev Microbiol. 51:1997;527-564. This is an excellent review of peptide-based global regulation, focusing on the mating pheromones of enterococci, which are different from most of the regulatory peptides in Gram-positive bacteria in that they do not represent ligands for signal receptors, nor do they represent density sensors.
    • (1997) Annu Rev Microbiol , vol.51 , pp. 527-564
    • Dunny, G.M.1    Leonard, B.A.2
  • 34
    • 0026501829 scopus 로고
    • Aggregation substance of Enterococcus faecalis mediates adhesion to cultured renal tubular cells
    • Kreft B, Marre R, Schramm U, Wirth R Aggregation substance of Enterococcus faecalis mediates adhesion to cultured renal tubular cells. Infect Immun. 60:1992;25-30.
    • (1992) Infect Immun , vol.60 , pp. 25-30
    • Kreft, B.1    Marre, R.2    Schramm, U.3    Wirth, R.4
  • 36
    • 0028007337 scopus 로고
    • A plasmid-encoded surface protein on Enterococcus faecalis augments its internalization by cultured intestinal epithelial cells
    • Olmsted SB, Dunny GM, Erlandsen SL, Wells CL A plasmid-encoded surface protein on Enterococcus faecalis augments its internalization by cultured intestinal epithelial cells. J Infect Dis. 170:1994;1549-1556.
    • (1994) J Infect Dis , vol.170 , pp. 1549-1556
    • Olmsted, S.B.1    Dunny, G.M.2    Erlandsen, S.L.3    Wells, C.L.4


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