A distinct 5′ flanking var gene region regulates Plasmodium falciparum variant erythrocyte surface antigen expression in placental malaria

Molecular Microbiology

Volumn 45, Issue 1, 2002, Pages 155-167

  Vázquez Macías, Aleida ^a   Martínez Cruz, Perla ^a   Castañeda Patlán, María Cristina ^a   Scheidig, Christine ^b   Gysin, Jürg ^c   Scherf, Artur ^b   Hernández Rivas, Rosaura ^d  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUT PASTEUR   (France)

^c SERVICE DE SANTÉ DES ARMÉES   (France)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN 4 SULFATE; ERYTHROCYTE ANTIGEN; PROTOZOAL DNA; REPETITIVE DNA; MEMBRANE ANTIGEN; PARASITE ANTIGEN;

5' UNTRANSLATED REGION; AFRICA; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; BRAZIL; CHROMOSOME; CONTROLLED STUDY; DNA FLANKING REGION; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; MALARIA FALCIPARUM; MULTIGENE FAMILY; NONHUMAN; PARASITE ISOLATION; PATHOGENESIS; PLACENTA; PLASMODIUM FALCIPARUM; PREGNANCY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN VARIANT; PROTOZOAL GENETICS; REGULATOR GENE; SEQUENCE HOMOLOGY; SEQUENCE TAGGED SITE; TELOMERE; VAR GENE; ANIMAL; ANTIGENIC VARIATION; CHO CELL; FEMALE; GENETICS; HAMSTER; HUMAN; METABOLISM; PARASITOLOGY; PREGNANCY COMPLICATION;

ANIMALIA; PLASMODIUM FALCIPARUM; PROTOZOA;

5' UNTRANSLATED REGIONS; ANIMALS; ANTIGENIC VARIATION; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; CHO CELLS; CRICETINAE; ERYTHROCYTES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALARIA, FALCIPARUM; MULTIGENE FAMILY; PLACENTA; PLASMODIUM FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC;

EID: 0035982898     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02999.x     Document Type: Article

References (32)

1. Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection
2. Developmental selection of var gene expression in Plasmodium falciparum
3. Molecules on the surface of the Plasmodium falciparum infected erythocyte and their role in malaria pathogenesis and immune evasion
4. Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum
5. Cooperative silencing elements invar genes
6. Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum
7. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
8. Maternal antibodies block malaria
9. Characterisation of the chondroitin sulphate of Saimiri brain microvascular endothelial cells involved in Plasmodium falciparum cytoadhesion
10. Ex vivo desequestration of Plasmodium falciparum-infected erythrocytes from human placenta by chondroitin sulfate A
11. Separation and mapping of chromosomes of parasitic protozoa
12. Mutational analysis identifies a five base pair cis-acting sequence essential for GBP130 promoter activity in Plasmodium falciparum
13. Control of gene expression in Plasmodium falciparum
14. Variants of Plasmodium falciparum erythrocyte membrane protein 1 expressed by different placental parasites are closely related and adhere to chondroitin sulfate A
15. Genetic diversity in the major merozoite surface antigen of Plasmodium falciparum: High prevalence of a third polymorphic form detected in strains derived from malaria patients
16. Genomic representation of var gene sequences in Plasmodium falciparum field isolates from different geographic regions
17. Transcription mapping of a 100 kb locus of Plasmodium falciparum identifies an intergenic region in which transcription terminates and reinitiates
18. Subtelomeric chromosome instability in Plasmodium falciparum: Short telomere-like sequence motifs found frequently at healed chromosome breakpoints
19. Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion
20. Recombinant human thrombomodulin (csa+): A tool for analyzing Plasmodium falciparum adhesion to chondroitin-4-sulfate
21. The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1
22. Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A
23. Multiple infections and unusual distribution of block 2 of the MSA1 gene of Plasmodium falciparum detected in west African clinical isolates by polymerase chain reaction analysis
24. Antigenic variation in malaria: In situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum
25. Molecular mechanisms of Plasmodium falciparum placental adhesion
26. Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain
27. Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family
28. The problem of malaria and malaria control in pregnancy in sub-Saharan Africa
29. A study of var gene transcription in vitro using universal var gene primers
30. Genomic distribution and functional characterisation of two distinct and conserved Plasmodium falciparum var gene 5′ flanking sequences
31. Cyto-adherence and rosetting in the pathogenesis of severe malaria
32. Transfection of Plasmodium falciparum within human red blood cells