Overexpression of synuclein-γ in pancreatic adenocarcinoma

Cancer

Volumn 101, Issue 1, 2004, Pages 58-65

  Li, Zhengkui ^a   Sclabas, Guido M ^a   Peng, Bailu ^a   Hess, Kenneth R ^a   Abbruzzese, James L ^a   Evans, Douglas B ^a   Chiao, Paul J ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Immunohistochemical analysis; Overexpression; Pancreatic carcinoma; Serum marker; Synuclein

Indexed keywords

BIOCHEMICAL MARKER; GAMMA SYNUCLEIN; MESSENGER RNA;

ARTICLE; BLOOD SAMPLING; CANCER CELL CULTURE; CANCER INVASION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERIAL ANALYSIS OF GENE EXPRESSION; WESTERN BLOTTING;

ADENOCARCINOMA; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE, TUMOR; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; NERVE TISSUE PROTEINS; PANCREATIC NEOPLASMS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNUCLEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 3042616974     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.20321     Document Type: Article

References (28)

1. Iwai A, Masliah E, Yoshimoto M, et al. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 1995;14:467-475.
2. Giasson BI, Lee VM. Parkin and the molecular pathways of Parkinson's disease. Neuron. 2001;31:885-888.
3. Shastry BS. Parkinson disease: etiology, pathogenesis and future of gene therapy. Neurosci Res. 2001;41:5-12.
4. Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E. Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders. Am J Pathol. 1998;152:367-372.
5. Jakes R, Spillantini MG, Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett. 1994;345: 27-32.
6. Surguchov A, Palazzo RE, Surgucheva I. Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction. Cell Motil Cytoskeleton. 2001;49:218-228.
7. Buchman VL, Adu J, Pinon LG, Ninkina NN, Davies AM. Persyn, a member of the synuclein family, influences neurofilament network integrity. Nat Neurosci. 1998;1:101-103.
8. Akopian AN, Wood JN. Peripheral nervous system-specific genes identified by subtractive cDNA cloning. J Biol Chem. 1995;270:21264-21270.
9. Lavedan C, Leroy E, Dehejia A, et al. Identification, localization and characterization of the human γ-synuclein gene. Hum Genet. 1998;103:106-112.
10. Buchman VL, Hunter HJ, Pinon LG, et al. Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system. J Neurosci. 1998;18:9335-9341.
11. Petersen K, Olesen OF, Mikkelsen JD. Developmental expression of α-synuclein in rat hippocampus and cerebral cortex. Neuroscience. 1999;91:651-659.
12. Ji H, Liu YE, Jia T, et al. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res. 1997;57:759-764.
13. Ninkina NN, Alimova-Kost MV, Paterson JW, et al. Organization, expression and polymorphism of the human persyn gene. Hum Mol Genet. 1998;7:1417-1424.
14. Jia T, Liu YE, Liu J, Shi YE. Stimulation of breast cancer invasion and metastasis by synuclein γ. Cancer Res. 1999; 59:742-747.
15. Pan ZZ, Bruening W, Giasson BI, Lee VM, Godwin AK. Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. J Biol Chem. 2002;277:35050-35060.
16. Iacobuzio-Donahue CA, Ashfaq R, Maitra A, et al. Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res. 2003;63:8614-8622.
17. Rozen S, Skaletsky HJ. Primer3 on the WWW for general users and for biologist programmers. Totowa, NJ: Humana Press, 2000.
18. Fujioka S, Sclabas GM, Schmidt C, et al. Function of nuclear factor κB in pancreatic cancer metastasis. Clin Cancer Res. 2003;9:346-354.
19. Sato Y, Nio Y, Song MM, et al. p53 protein expression as prognostic factor in human pancreatic cancer. Anticancer Res. 1997;17:2779-2788.
20. Dong M, Nio Y, Tamura K, et al. Ki-ras point mutation and p53 expression in human pancreatic cancer: a comparative study among Chinese, Japanese, and Western patients. Cancer Epidemiol Biomarkers Prev. 2000;9:279-284.
21. Hu YX, Watanabe H, Ohtsubo K, et al. Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. Clin Cancer Res. 1997;3: 1473-1477.
22. Iacobuzio-Donahue CA, Klimstra DS, Adsay NV, et al. Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol. 2000;157:755-761.
23. Safran H, Steinhoff M, Mangray S, et al. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol. 2001;24:496-499.
24. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549-554.
25. Yamamoto H, Itoh F, Nakamura H, et al. Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. Cancer Res. 2001; 61:3139-3144.
26. Lu A, Gupta A, Li C, et al. Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequences. Oncogene. 2001;20:5173-5185.
27. Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK. Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer. 2000;88:2154-2163.
28. Gupta A, Godwin AK, Vanderveer L, Lu A, Liu J. Hypomethylation of the synuclein γ gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma. Cancer Res. 2003;63:664-673.