Effects of glutathione, N-acetyl-cysteine, α-lipoic acid and dihydrolipoic acid on the cytotoxicity of a 2-pyridylcarboxamidrazone antimycobacterial agent in human mononuclear leucocytes in vitro

Environmental Toxicology and Pharmacology

Volumn 17, Issue 3, 2004, Pages 143-148

  Coleman, Michael D ^a   Khan, Nazish ^a   Welton, Graham ^a   Lambert, Peter A ^a   Tims, Katy J ^a   Rathbone, Daniel L ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

2 Pyridyl amidrazone; Cytotoxicity; DHLA; GSH; Human; Leucocytes

Indexed keywords

2 PYRIDYLCARBOXAMIDRAZONE; ACETYLCYSTEINE; ANTIMYCOBACTERIAL AGENT; DIHYDROLIPOATE; GLUTATHIONE; ISONIAZID; PYRIDINE DERIVATIVE; THIOCTIC ACID; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 3042616565     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2004.04.002     Document Type: Article

References (22)

1. Attri S., Rana S.V., Vaiphei K., Sodhi C.P., Katyal R., Goel R.C., Nain C.K., Singh K. Isoniazid and rifampicin-induced oxidative hepatic injury-protection by N-acetyl cysteine. Hum. Exp. Toxicol. 19:2000;517
2. Bast A., Haenen G.R.M.M. Lipoic acid: a multifunctional antioxidant. Biofactors. 17:2003;207
3. Biewenga G.P., Haenen G.R.R.M., Bast A. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. 29:1997;315
4. Billington D.C., Coleman M.D., Ibiabuo J., Lambert P.A., Rathbone D.L., Tims K.J. Synthesis and antimycobacterial activity of some heteroarylcarboxyamidrazone derivatives. Drug Design Des. 15:1998;269
5. Boyum A. Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol. 5:1976;5
6. Bustamante J., Slater A.F.G., Orrenius S. Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid. Free Rad. Biol. Med. 19:1995;339
7. Coleman M.D. Dapsone: modes of action, toxicity and possible strategies for increasing patient tolerance. Brit. J. Dermatol. 129:1993;507
8. Coleman M.D., Kohl C. A comparison of the in vitro toxicities of sulphametrole and sulphamethoxazole. Pharm. Sci. 1:1995;479
9. Coleman M.D., Abberley L., Rathbone D.L., Lambert P.A., Billington D.C. Preliminary toxicological testing of candidate amidrazone anti-mycobacterial compounds. Environ. Toxicol. Pharmacol. 7:1999;59
10. Coleman M.D., Rathbone D.L., Endersby C.R., Hovey M.C., Lambert P.A., Billington D.C. Preliminary toxicological testing of candidate amidrazone anti-mycobacterial compounds II. Environ. Toxicol. Pharmacol. 8:2000;167
11. Coleman M.D., Rathbone D.L., Chima R., Lambert P.A., Billington D.C. Preliminary toxicological testing of candidate amidrazone anti-mycobacterial compounds III. Environ. Toxicol. Pharmacol. 9:2001;99
12. Coleman M.D., Tims K.J., Rathbone D.L. The use of computational QSAR analysis in the toxicological evaluation of a series of 2- pyridylcarboxamidrazone candidate anti-tuberculosis compounds. Environ. Toxicol. Pharmacol. 14:2003;33
13. Coleman M.D., Taylor C.T. Effects of dihydrolipoic acid (DHLA) lipoic acid, N-acetyl cysteine and ascorbate on xenobiotic-mediated methaemoglobin formation in human erythrocytes in vitro. Environ. Toxicol. Pharmacol. 14:2003;121
14. Haenen G.R.R.M., Bast A. Scavenging of hypochlorous acid by lipoic acid. Biochem. Pharmacol. 42:1991;2244
15. Hoffer E., Baum Y., Tabak A., Taitelman U. N-acetylcysteine increases the glutathione content and protects rat alveolar type II cells against paraquat-induced cytotoxicity. Tetra. Lett. 84:1996;7
16. Javitz H.S., Ward M. Value of antimicrobials in the prevention and treatment of tuberculosis in the United States. Int. J. Tuber. Lung Dis. 6:2002;275
17. Mitchell J.R., Snodgrass W.R., Gillette J.R. The role of biotransformation in chemical-induced liver injury. Environ. Health Prespect. 15:1976;27
18. Nicod L., Viollon C., Regnier A., Jacqueson A., Richert L. Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells. Hum. Exp. Toxicol. 16:1997;28
19. Ornaghi F., Ferrini S., Prati M., Giavini E. The protective effects of N-acetyl L-cysteine against methyl mercury embryotoxicity in mice. Fund. Appl. Toxicol. 20:1993;437
20. Sarich T.C., Adams S.P., Petricca G., Wright J.M. Inhibition of isoniazid-induced hepatotoxicity in rabbits by treatment with an amidase inhibitor. J. Pharm. Exp. Ther. 289:1999;695
21. Spielberg S.P. Acetominophen toxicity in human lymphocytes in vitro. J. Pharm. Exp. Ther. 213:1980;395
22. Timbrell J.A., Mitchell J.R., Snodgrass W.R., Nelson S.D. Isoniazid hepatotoxicity: the relationship between covalent binding and metabolism in vivo. J. Pharmacol. Exper. Ther. 213:1980;364