Effects of dihydrolipoic acid (DHLA), α-lipoic acid. N-acetyl cysteine and ascorbate on xenobiotic-mediated methaemoglobin formation in human erythrocytes in vitro

Environmental Toxicology and Pharmacology

Volumn 14, Issue 3, 2003, Pages 121-127

  Coleman, Michael D ^a   Taylor, Clare T ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Ascorbate; Dihydrolipoic acid (DHLA); Human; In vitro; Methylene blue; N acetyl cysteine

Indexed keywords

4 AMINOPHENOL; ACETYLCYSTEINE; ASCORBIC ACID; DIHYDROLIPOATE; METHEMOGLOBIN; METHYLENE BLUE; N HYDROXYDAPSONE; SODIUM NITRITE; THIOCTIC ACID; XENOBIOTIC AGENT;

ADULT; ARTICLE; ATTENUATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ERYTHROCYTE METABOLISM; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; INCUBATION TIME; NORMAL HUMAN; OXIDATION; PREMEDICATION; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

EID: 0242285686     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(03)00048-6     Document Type: Article

References (24)

1. Biewenga G.P., Haenen G.R.R.M., Bast A. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. 29:1997;315.
2. Bunn H.F., Forget B.G. Hemoglobin: Molecular, Genetic and Clinical Aspects. 1986;634-662 WB Saunders, Philadephia.
3. Coleman M.D., Baker C.D. Effects of the antioxidants dihydrolipoic acid (DHLA) and probucol on xenobiotic-mediated methaemoglobin formation in human diabetic and non-diabetic erythrocytes in vitro. Environ. Toxicol. Pharmacol. 9:2001;161.
4. Coleman M.D., Coleman N.A. Drug-induced methaemoglobinaemia. Drug Saf. 14:1996;394.
5. Coleman M.D., Kuhns M.K. Methaemoglobin formation by 4- aminopropriophenone in single and dual compartmental systems. Environ. Toxicol. Pharmacol. 7:1999;75.
6. Coleman M.D., Taylor C.H. Bioactivation of benzocaine in rat and human microsomal systems in vitro. Environ. Toxicol. Pharmacol. 3:1997;47.
7. Coleman M.D., Walker C.L. Effects of the antioxidants α-lipoic acid and α-tocopherol on xenobiotic mediated methaemoglobin formation in human diabetic and non-diabetic erythrocytes in vitro. Environ. Toxicol. Pharmacol. 8:2000;127.
8. Coleman M.D., Breckenridge A.M., Park B.K. Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes. Br. J. Clin. Pharmacol. 28:1989;389.
9. Coleman M.D., Rhodes L.A., Scott A.K., Verbov J., Friedmann P., Breckenridge A.M., Park B.K. The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients. Br. J. Clin Pharmacol. 34:1992;244.
10. Coleman M.D., Hayes P.J., Jacobus D.P. Methaemoglobin formation due to nitrite, disulfiram, 4-aminophenol and monoacetyldapsone hydroxylamine in diabetic and non-diabetic human erythrocytes in vitro. Environ. Toxicol. Pharmacol. 5:1998;61.
11. Coleman M.D., Tolley H.L., Desai A.K. Monitoring antioxidant effects using methaemoglobin formation in diabetic erythrocytes. Br. J. Diabetes Vasc. Dis. 1:2001;88.
12. Coleman M.D., Eason R.C., Bailey C.J. The therapeutic use of lipoic acid in diabetes: a current perspective. Environ. Toxicol. Pharmacol. 10:2001;167.
13. Coleman M.D., Fernandez S., Khanderia L. A novel clinical monitoring method to evaluate a triple antioxidant combination (vitamins E, C and α-lipoic acid) in diabetic volunteers using in vitro methaemoglobin formation. Environ. Toxicol. Pharmacol. 14:2003;33.
14. de Vries N., De Flora S. N-acetyl cysteine. J. Cell Biochem. Suppl. 17F:1993;270.
15. Eckert K.G. The metabolism of aminophenols in erythrocytes. Xenobiotica. 18:1988;1319.
16. Eyer P. Detoxication of N-oxygenated arylamines in erythrocytes. An overview. Xenobiotica. 18:1988;1327.
17. Feig S.A. Methemoglobinemia. Nathan D.G., Oski F.A. Hematology of Infancy and Childhood. 1981;654-686 WB Saunders, Philadelphia.
18. Foxworth J.W., Roberts J.A., Mahmoud S.F. Acquired methemoglobinemia: a case report. Mol. Med. 84:1987;187-189.
19. Goluboff N., Wheaton R. Methylene blue induced cyanosis and acute hemolytic anemia complicating the treatment of methemoglobinemia. J. Pediatr. 58:1961;86.
20. Kiese M. The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation. Pharmacol. Rev. 18:1966;1091.
21. Kramer P.A., Glader B.E., Li T.K. Mechanism of methaemoglobin formation by diphenylsulphones. Biochem. Pharmacol. 21:1972;1265.
22. Mansouri A., Lurie A.A. Methemoglobinaemia. Am. J. Hematol. 42:1993;7-12.
23. Moon R.E., Camparesi E.M. Respiratory monitoring. Miller R.D. third ed Anesthesia. 1:1990;1140 Churchill Livingston.
24. Posthumus M.D., van Berkel W. Cytochrome b5 reductase deficiency and uncommon cause of cyanosis. Neth. J. Med. 44:1994;136-140.