Effect of free radicals on adenosine A2A and dopamine D 2 receptors in the striatum of young adult and aged rats

Neurochemistry International

Volumn 45, Issue 5, 2004, Pages 733-738

  Alfaro, Tiago M ^a   Vigia, Emanuel ^a   Oliveira, Catarina R ^a   Cunha, Rodrigo A ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

A2A receptor; Adenosine; Aging; Binding; D2 receptor; Dopamine; Free radicals; Striatum

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; DOPAMINE 2 RECEPTOR; FREE RADICAL; PROTEIN; RACLOPRIDE;

AGING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORPUS STRIATUM; HYPOTHESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR DENSITY;

AGING; ANIMALS; DOPAMINE ANTAGONISTS; FREE RADICALS; LIPID PEROXIDATION; MALE; MEMBRANES; NEOSTRIATUM; NEUROPROTECTIVE AGENTS; PYRIMIDINES; RACLOPRIDE; RATS; RECEPTOR, ADENOSINE A2A; RECEPTORS, DOPAMINE D2; TRIAZOLES;

ANIMALIA; PARKINSONIA;

EID: 3042601106     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2004.02.003     Document Type: Article

References (29)

1. 3H ]aspartate release in cultured retina cells exposed to oxidative stress Neurochem. Int. 36:2000;255-265
2. Almeida C.G., de Mendonça A., Cunha R.A., Ribeiro J.A. Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices. Neurosci. Lett. 339:2003;127-130
3. Ando S., Kon K., Aino K., Totani Y. Increased levels of lipid peroxides in aged rat brain as revealed by direct assay of peroxide values. Neurosci. Lett. 113:1990;199-204
4. Beal M.F. Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann. N. Y. Acad. Sci. 991:2003;120-131
5. 2A receptor antagonists. Br. J. Pharmacol. 135:2002;1435-1442
6. 2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. NeuroReport. 6:1995;1583-1588
7. Cunha R.A., Almeida T., Ribeiro J.A. Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats. J. Neurochem. 76:2001;372-382
8. Davies M.J. Singlet oxygen-mediated damage to proteins and its consequences. Biochem. Biophys. Res. Commun. 305:2003;761-770
9. Hegner D. Age-dependence of molecular and functional changes in biological membrane properties. Mech. Ageing Dev. 14:1980;101-118
10. Jenner P. Oxidative stress in Parkinson's disease. Ann. Neurol. 53(Suppl. 3):2003;S26-S36
11. Mardsen C.D., Parkes J.D. Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet. 1:1977;345-349
12. Marshall J.F., Berrios N. Movement disorders of aged rats: reversal by dopamine receptor stimulation. Science. 206:1979;477-479
13. Masino S.A., Mesches M.H., Bickford P.C., Dunwiddie T.V. Acute peroxide treatment of rat hippocampal slices induces adenosine-mediated inhibition of excitatory transmission in area CA1. Neurosci. Lett. 274:1999;91-94
14. Masoro E.J. Use of rodents as models for the study of "normal aging": conceptual and practical issues. Neurobiol. Aging. 12:1991;639-643
15. McNeill T.H., Koek L.L., Brown S.A., Rafols J.A. Age-related changes in the nigrostriatal system. Ann. N. Y. Acad. Sci. 515:1988;239-248
16. Misu Y., Goshima Y., Miyamae T. Is DOPA a neurotransmitter? Trends Pharmacol Sci. 23:2002;262-268
17. 2-receptors. Neuroscience. 36:1990;403-410
18. Obeso J.A., Rodríguez-Oroz M.C., Rodríguez M., Lanciego J.L., Artieda J., Gonzalo N., Olanow C.W. Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci. 10(Suppl.):2000;S8-S19
19. Olah M.E., Stiles G.L. The role of receptor structure in determining adenosine receptor activity. Pharmacol. Ther. 85:2000;55-75
20. 1 adenosine receptor ligands in rat brain membranes. Neurochem. Int. 26:1995;263-268
21. Popoli P., Betto P., Rimondini R., Reggio R., Pezzola A., Ricciarello G., Fuxe K., Ferré S. Age-related alteration of the adenosine/dopamine balance in the rat striatum. Brain Res. 795:1998a;297-300
22. 2A receptor antagonists stimulate motor activity: evidence for an increased effectiveness in aged rats. Neurosci. Lett. 251:1998b;201-204
23. 2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. J. Neurophysiol. 90:2003;1295-1303
24. Rego A.C., Oliveira C.R. Dual effect of lipid peroxidation on the membrane order of retinal cells in culture. Arch. Biochem. Biophys. 321:1995;127-136
25. 2 receptor in the rat striatum. Neurosci. Lett. 158:1993;121-124
26. 2A antagonists in PD. Neurology. 58:2002;1154-1160
27. Spiteller G. Are changes of the cell membrane structure causally involved in the aging process? Ann. N. Y. Acad. Sci. 959:2002;30-44
28. Suzuki M., Hatano K., Sakiyama Y., Kawasumi Y., Kato T., Ito K. Age-related changes of dopamine D1-like and D2-like receptor binding in the F344/N rat striatum revealed by positron emission tomography and in vitro receptor autoradiography. Synapse. 41:2001;285-293
29. 2A receptors. Prog. Neurobiol. 59:1999;355-396