Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 15, 2004, Pages 3925-3928

  Al awar, Rima S ^a   Ray, James E ^a   Hecker, Kyle A ^a   Joseph, Sajan ^a   Huang, Jianping ^a   Shih, Chuan ^a   Brooks, Harold B ^a   Spencer, Charles D ^a   Watkins, Scott A ^a   Schultz, Richard M ^a   Considine, Eileen L ^a   Faul, Margaret M ^a   Sullivan, Kevin A ^a   Kolis, Stanley P ^a   Carr, Michael A ^a   Zhang, Faming ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

cdk4; Indolocarbazoles

Indexed keywords

CARBAZOLE DERIVATIVE; INDOLE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR;

ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; COLON CARCINOMA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

AZA COMPOUNDS; BINDING SITES; CDC2-CDC28 KINASES; CELL CYCLE; CYCLIN-DEPENDENT KINASE 2; ENZYME INHIBITORS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042596599     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.088     Document Type: Article

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