Effect of ONO1714, a specific inducible nitric oxide synthase inhibitor, on lung lymph filtration and gas exchange during endotoxemia in unanesthetized sheep

Anesthesiology

Volumn 101, Issue 1, 2004, Pages 59-65

  Koizumi, Tomonobu ^a   Ogasawara, Hitoshi ^b   Yamamato, Hiroshi ^b   Tsushima, Kenji ^b   Ruan, Zonghai ^b   Jian, Mingyuan ^b   Fujimoto, Keisaku ^b   Kubo, Keishi ^b  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 3 IMINO 5 METHYL 2 AZABICYCLO[4.1.0]HEPTANE; ESCHERICHIA COLI ENDOTOXIN; HEPTANE DERIVATIVE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; DRUG EFFECT; ENDOTOXEMIA; ENZYME INHIBITION; HEART LEFT ATRIUM PRESSURE; LUNG ARTERY PRESSURE; LUNG EDEMA; LUNG INJURY; LUNG LYMPH; LUNG VASCULAR RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME; SEPSIS; SHEEP;

ACUTE DISEASE; AMIDINES; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; ENDOTOXEMIA; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 2-RING; LUNG; LYMPH; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PULMONARY CIRCULATION; PULMONARY GAS EXCHANGE; RESPIRATORY INSUFFICIENCY; SEPSIS; SHEEP;

EID: 3042596437     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200407000-00011     Document Type: Article

References (35)

1. Moncada S, Palmar RMJ, Higgs EA: Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev 1991; 43:109-42
2. Payen D, Bernard C, Beloucif S: Nitric oxide in sepsis. Clin Chest Med 1996; 17:333-50
3. Knowles RG, Moncada S: Nitric oxide synthases in mammals. Biochem J 1994; 298:249-58
4. Fujii Y, Goldberg P, Hussain SNA: Contribution of macrophages pulmonary nitric oxide contribution in septic shock. Am J Respir Crit Care Med 1998; 157:1645-51
5. Sanders DB, Larson DF, Jablonowski C, Olsen L: Differential expression of inducible nitric oxide synthase in septic shock. J Extra Corpor Technol 1999; 31:118-24
6. Mitaka C, Hirata Y, Yokoyama K, Makita K, Imai T: A selective inhibitor for inducible nitric oxide synthase improves hypotension and lactic acidosis in canine endotoxic shock. Crit Care Med 2001; 29:2156-61
7. Yang F, Comtois AS, Fang L, Hartman NG, Blaise G: Nitric oxide-derived nitrate anion contributes to endotoxic shock and multiple organ injury/dysfunction. Crit Care Med 2002; 30:650-7
8. Ogasawara H, Koizumi T, Yamamoto H, Kubo K: Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep. J Cadiovasc Pharmacol 2003; 42:521-6
9. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, McGuire R, Schmalstieg F, Cox R, Hawkins H, Jodoin J, Lee S, Traber L, Herndon D, Traber D: Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model. Am J Physiol Regul Integr Comp Physiol 2003; 285:R366-72
10. Matsuo N: The role of intrapulmonary nitric oxide generation in the development of adult respiratory distress syndrome. Surg Today 1999; 29:1068-74
11. Sittipunt C, Steinberg KP, Ruzinski JT, Myles C, Zhu S, Goodman RB, Hudson LD, Matalon S, Martin TR: Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2001; 163:503-10
12. Kristof AS, Goldberg P, Laubach V, Hussain SNA: Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury. Am J Respir Crit Care Med 1998; 158:1883-9
13. Wang Le F, Patel M, Razavi HM, Weicker S, Joseph MG, McCormack DG, Mehta S: Role of inducible nitric oxide synthase in pulmonary microvascular protein leak in murine sepsis. Am J Respir Crit Care Med 2002; 165:1634-9
14. Misko TP, Moore WW, Kasten TP, Nickols GA, Corbett JA, Tilton RG, McDaniel ML, Williamson JR, Currie MG: Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 1993; 233:119-25
15. Mikawa K, Nishina K, Tamada M, Takao Y, Maekawa N, Obara H: Aminoguanidine attenuates endotoxin-induced acute lung injury in rabbits. Crit Care Med 1998; 26:905-11
16. Arkovitz MS, Wispe JR, Garcia VF, Szabo C: Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia. J Pediatr Surg 1996; 31:1009-15
17. Numata M, Suzuki S, Miyazawa N, Miyashita A, Nagashima Y, Inoue S, Kaneko T, Okubo T: Inhibition of inducible nitric oxide synthase prevents LPS-induced acute lung injury in dogs. J Immunol 1998; 160:3031-7
18. Evgenov OV, Hevroy O, Bremnes KE, Bjertnaes LJ: Effects of aminoguanidine on lung fluid filtration after endotoxin in awake sheep. Am J Respir Crit Care Med 2000; 162:465-70
19. Meyer J, Lentz CW, Stothert JC Jr, Traber LD, Herndon DN, Traber DL: Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia. Crit Care Med 1994; 22:306-12
20. Hinder SR, Deyo DJ, Bone HG, McGuire R, Traber LD, Traber DL: Role of nitric oxide in sepsis-associated pulmonary edema. Am J Respir Crit Care Med 1999; 159:252-7
21. w-nitro-L-arginine on the distribution of pulmonary vascular resistance and prostanoid products. Exp Lung Res 2002; 28:473-84
22. Naka M, Nanbu T, Kobayashi K, Kamanaka Y, Komeno M, Yanase R, Fukutomi T, Fujimura S, Seo HG, Fujiwara N, Ohuchida S, Suzuki K, Kondo K, Taniguchi N: A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cycle amidine derivative. Biochem Bio Res Com 2000; 270:663-7
23. Okamoto I, Abe M, Shibata K, Shimizu N, Sakata N, Katsuragi T, Tanaka K: Evaluating the role of inducible nitric oxide synthase using a novel and selective inducible nitric oxide synthase inhibitor in septic lung injury produced by cecal ligation and puncture. Am J Respire Crit Care Med 2000; 162:716-22
24. Nishina K, Mikawa K, Kodama S, Obata H: ONO1714, a newly inducible nitric oxide synthase inhibitor, attenuates sepsis-induced diaphragmatic dysfunction in hamsters. Anesth Analg 2001; 92:959-66
25. 15N] nitrate in biological fluids. Anal Biochem 1982; 126:131-8
26. Lamy M, Fallat RJ, Koeniger E, Dietrich HP, Ratliff JL, Eberhart RC, Tucker HJ, Hill JD: Pathologic features and mechanisms of hypoxemia in adult respiratory distress syndrome. Am Rev Respir Dis 1976; 114:267-83
27. Hutchison AA, Ogletree ML, Snapper JR, Brigham KL: Effect of endotoxemia on hypoxic pulmonary vasoconstriction in unanesthetized sheep. J Appl Physiol 1985; 58:1463-8
28. Theissen JL, Loick HM, Curry BB, Traber LD, Herndon DN, Traber DL: Time course of hypoxic pulmonary vasoconstriction after endotoxin infusion in unanesthetized sheep. J Appl Physiol 1991; 70:2120-5
29. Fischer SR, Deyo DJ, Bone HG, McGuire R, Traber LD, Traber DL: Nitric oxide synthase inhibition restores hypoxic pulmonary vasoconstriction in sepsis. Am J Respir Crit Care Med 1997; 156:833-9
30. Ullrich R, Bloch KD, Ichinose F, Steudel W, Zapol WM: Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest 1999; 104:1421-9
31. Lorente JA, Landin L, Renes E, De Pablo R, Jorge P, Rodena E, Liste D: Role of nitric oxide in the hemodynamic changes of sepsis. Crit Care Med 1993; 21:759-67
32. Landin L, Lorente JA, Renes E, Canas P, Jorge P, Liste D: Inhibition of nitric oxide synthesis improves the vasoconstrictive effect of noradrenaline in sepsis. Chest 1994; 106:250-6
33. Liu S, Adcock M, Old RW, Barnes PJ, Evans TW: Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA. Biochem Biophys Res Commun 1993; 196:1208-13
34. Laskin DL, Pendino KJ: Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol 1995; 35:655-77
35. Kooy NW, Royall JA, Ye YZ, Kelly DR, Beckman JS: Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Respir Crit Care Med 1995; 151:1250-4