Lung and brain damage in preterm newborns: Are they related? How? Why?

Biology of the Neonate

Volumn 85, Issue 4, 2004, Pages 305-313

  Dammann, Olaf ^a   Leviton, Alan ^b   Bartels, Dorothee B ^a   Dammann, Christiane E L ^a,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

Bronchopulmonary dysplasia; Cerebral palsy; Infant, premature; Infection; Inflammation; Leukomalacia, periventricular; White matter damage

Indexed keywords

ANTIBIOTIC AGENT; GLUCOCORTICOID; LUNG SURFACTANT; STEROID;

ARTIFICIAL VENTILATION; BRAIN DEVELOPMENT; BRAIN INJURY; CEREBRAL PALSY; CHORIOAMNIONITIS; CONFERENCE PAPER; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; DRUG EXPOSURE; DRUG USE; HUMAN; HYPOTHESIS; IMAGING; INFLAMMATION; INTRAUTERINE INFECTION; LUNG DEVELOPMENT; LUNG DYSPLASIA; LUNG FUNCTION; LUNG INJURY; METHODOLOGY; PERINATAL PERIOD; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PREMATURITY; PRENATAL PERIOD; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME; RISK; RISK ASSESSMENT; RISK FACTOR; ULTRASOUND; WHITE MATTER; WHITE MATTER DAMAGE;

BRAIN DISEASES; BRONCHOPULMONARY DYSPLASIA; CEREBRAL PALSY; GLUCOCORTICOIDS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFECTION; INFLAMMATION; LUNG DISEASES; RESPIRATION, ARTIFICIAL;

EID: 3042582239     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000078175     Document Type: Conference Paper

References (88)

1. Goldenberg RL, Hauth JC, Andrews WW: Intrauterine infection and preterm delivery. N Engl J Med 2000;342:1500-1507.
2. Speer CP: Inflammation and bronchopulmonary dysplasia. Semin Neonatol 2003;8:29-38.
3. Dammann O, Leviton A: Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. Pediatr Res 1997;42:1-8.
4. Wu YW: Systematic review of chorioamnionitis and cerebral palsy. Ment Retard Dev Disabil Res Rev 2002;8:25-29.
5. Dammann O, Kuban KC, Leviton A: Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm. Ment Retard Dev Disabil Res Rev 2002;8:46-50.
6. Eklind S, Mallard C, Leverin AL, Gilland E, Blomgren K, Mattsby-Baltzer I, Hagberg H: Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury. Eur J Neurosci 2001;13:1101-1106.
7. Van Marter LJ, Dammann O, Allred EN, Leviton A, Pagano M, Moore M, Martin C: Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr 2002;140:171-176.
8. Jobe AH: Antenatal factors and the development of bronchopulmonary dysplasia. Semin Neonatol 2003;8:9-17.
9. Jobe AH: The new BPD: An arrest of lung development. Pediatr Res 1999;46:641-643.
10. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM: Abnormal pulmonary outcomes in premature infants: Prediction from oxygen requirement in the neonatal period. Pediatrics 1988;82:527-532.
11. Jobe AH, Bancalari E: Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723-1729.
12. Mai XM, Gaddlin PO, Nilsson L, Finnstrom O, Bjorksten B, Jenmalm MC, Leijon I: Asthma, lung function and allergy in 12-year-old children with very low birth weight: A prospective study. Pediatr Allergy Immunol 2003;14:184-192.
13. Gilles FH, Leviton A, Golden JA, Paneth N, Rudelli RD: Groups of histopathologic abnormalities in brains of very low birthweight infants. J Neuropathol Exp Neurol 1998;57:1026-1034.
14. Leviton A, Gilles F: Ventriculomegaly, delayed myelination, white matter hypoplasia, and 'periventricular' leukomalacia: How are they related? Pediatr Neurol 1996;15:127-136.
15. Leviton A, Paneth N: White matter damage in preterm newborns: An epidemiologic perspective. Early Hum Dev 1990;24:1-22.
16. Larroque B, Marret S, Ancel PY, Arnaud C, Marpeau L, Supernant K, Pierrat V, Roze JC, Matis J, Cambonie G, Burguet A, Andre M, Kaminski M, Breart G: White matter damage and intraventricular hemorrhage in very preterm infants: The EPIPAGE study. J Pediatr 2003;143:477-483.
17. Dammann O, Leviton A: The role of perinatal brain damage in developmental disabilities: An epidemiologic perspective. Ment Retard Dev Disabil Res Rev 1997;3:13-21.
18. O'Shea TM: Cerebral palsy in very preterm infants: New epidemiological insights. Ment Retard Dev Disabil Res Rev 2002;8:135-145.
19. Kuban KC, Leviton A: Cerebral palsy. N Engl J Med 1994;330:188-195.
20. Rojas MA, Gonzalez A, Bancalari E, Claure N, Poole C, Silva-Neto G: Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease. J Pediatr 1995;126:605-610.
21. O'Shea TM, Goldstein DJ, deRegnier RA, Sheaffer CI, Roberts DD, Dillard RG: Outcome at 4 to 5 years of age in children recovered from neonatal chronic lung disease. Dev Med Child Neurol 1996;38:830-839.
22. Gregoire MC, Lefebvre F, Glorieux J: Health and developmental outcomes at 18 months in very preterm infants with bronchopulmonary dysplasia. Pediatrics 1998;101:856-860.
23. Skidmore MD, Rivers A, Hack M: Increased risk of cerebral palsy among very low-birthweight infants with chronic lung disease. Dev Med Child Neurol 1990;32:325-332.
24. Vohr BR, Coll CG, Lobato D, Yunis KA, O'Dea C, Oh W: Neurodevelopmental and medical status of low-birthweight survivors of bronchopulmonary dysplasia at 10 to 12 years of age. Dev Med Child Neurol 1991;33:690-697.
25. Gray PH, Burns YR, Mohay HA, O'Callaghan MJ, Tudehope DI: Neurodevelopmental outcome of preterm infants with bronchopulmonary dysplasia. Arch Dis Child 1995;73:F128-F134.
26. Vrlenich LA, Bozynski ME, Shyr Y, Schork MA, Roloff DW, McCormick MC: The effect of bronchopulmonary dysplasia on growth at school age. Pediatrics 1995;95:855-859.
27. Majnemer A, Riley P, Shevell M, Birnbaum R, Greenstone H, Coates AL: Severe bronchopulmonary dysplasia increases risk for later neurological and motor sequelae in preterm survivors. Dev Med Child Neurol 2000;42:53-60.
28. Robertson CM, Etches PC, Goldson E, Kyle JM: Eight-year school performance, neurodevelopmental, and growth outcome of neonates with bronchopulmonary dysplasia: A comparative study. Pediatrics 1992;89:365-372.
29. Dammann O, Allred EN, Van Marter LJ, Dammann CE, Leviton A: Bronchopulmonary dysplasia is not associated with ultrasounddefined cerebral white matter damage in preterm newborns. Pediatr Res 2004;55:319-325.
30. Holling EE, Leviton A: Characteristics of cranial ultrasound white matter echolucencies that predict disability: A review. Dev Med Child Neurol 1999;41:136-139.
31. Maalouf EF, Duggan PJ, Counsell SJ, Rutherford MA, Cowan F, Azzopardi D, Edwards AD: Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants. Pediatrics 2001;107:719-727.
32. Bancalari E, Claure N, Sosenko IRS: Bronchopulmonary dysplasia: Changes in pathogenesis, epidemiology and definition. Semin Neonatol 2003;8:63-71.
33. Romero R, Salafia CM, Athanassiadis AP, Hanaoka S, Mazor M, Sepulveda W, Bracken MB: The relationship between acute inflammatory lesions of the preterm placenta and amniotic fluid microbiology. Am J Obstet Gynecol 1992;166:1382-1388.
34. Watterberg KL, Demers LM, Scott SM, Murphy S: Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 1996;97:210-215.
35. Jobe AH, Newnham JP, Willet KE, Sly P, Ervin MG, Bachurski C, Possmayer F, Hallman M, Ikegami M: Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs. Am J Obstet Gynecol 2000;182:401-408.
36. Willet KE, Jobe AH, Ikegami M, Newnham J, Brennan S, Sly PD: Antenatal endotoxin and glucocorticoid effects on lung morphometry in preterm lambs. Pediatr Res 2000;48:782-788.
37. Schmidt B, Cao L, Mackensen-Haen S, Kendziorra H, Klingel K, Speer CP: Chorioamnionitis and inflammation of the fetal lung. Am J Obstet Gynecol 2001;185:173-177.
38. Murch SH, Costeloe K, Klein NJ, Rees H, McIntosh N, Keeling JW, MacDonald TT: Mucosal tumor necrosis factor-alpha production and extensive disruption of sulfated glycosaminoglycans begin within hours of birth in neonatal respiratory distress syndrome. Pediatr Res 1996;40:484-489.
39. Hitti J, Krohn MA, Patton DL, Tarczy-Hornoch P, Hillier SL, Cassen EM, Eschenbach DA: Amniotic fluid tumor necrosis factoralpha and the risk of respiratory distress syndrome among preterm infants. Am J Obstet Gynecol 1997;177:50-56.
40. Redline RW, Wilson-Costello D, Hack M: Placental and other perinatal risk factors for chronic lung disease in very low birth weight infants. Pediatr Res 2002;52:713-719.
41. Ohyama M, Itani Y, Yamanaka M, Goto A, Kato K, Ijiri R, Tanaka Y: Re-evaluation of chorioamnionitis and funisitis with a special reference to subacute chorioamnionitis. Hum Pathol 2002;33:183-190.
42. Ogunyemi D, Murillo M, Jackson U, Hunter N, Alperson B: The relationship between placental histopathology findings and perinatal outcome in preterm infants. J Matern Fetal Neonatal Med 2003;13:102-109.
43. Yoon BH, Romero R, Kim KS, Park JS, Ki SH, Kim BI, Jun JK: A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1999;181:773-779.
44. Matsuda T, Nakajima T, Hattori S, Hanatani K, Fukazawa Y, Kobayashi K, Fujimoto S: Necrotizing funisitis: Clinical significance and association with chronic lung disease in premature infants. Am J Obstet Gynecol 1997;177:1402-1407.
45. Kim CJ, Yoon BH, Romero R, Moon JB, Kim M, Park SS, Chi JG: Umbilical arteritis and phlebitis mark different stages of the fetal inflammatory response. Am J Obstet Gynecol 2001;185:496-500.
46. Leviton A, Gilles F, Neff R, Yaney P: Multivariate analysis of risk of perinatal telencephalic leucoencephalopathy. Am J Epidemiol 1976;104:621-626.
47. Dammann O, Leviton A: Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant. Semin Pediatr Neurol 1998;5:190-201.
48. Redline RW, Wilson-Costello D, Borawski E, Fanaroff AA, Hack M: Placental lesions associated with neurologic impairment and cerebral palsy in very-low-birth-weight infants. Arch Pathol Lab Med 1998;122:1091-1098.
49. Yoon BH, Romero R, Park JS, Kim CJ, Kim SH, Choi JH, Han TR: Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol 2000;182:675-681.
50. Leviton A, Paneth N, Reuss ML, Susser M, Allred EN, Dammann O, Kuban K, Van Marter LJ, Pagano M, Hegyi T, Hiatt M, Sanocka U, Shahrivar F, Abiri M, DiSalvo D, Doubilet P, Kairam R, Kazam E, Kirpekar M, Rosenfeld D, Schonfeld S, Share J, Collins M, Genest D, Heller D, Shen-Schwarz S: Maternal infection, fetal inflammatory response, and brain damage in very low birthweight infants. Pediatr Res 1999;46:566-575.
51. Yoon BH, Romero R, Yang SH, Jun JK, Kim IO, Choi JH, Syn HC: Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol 1996;174:1433-1440.
52. Duggan PJ, Maalouf EF, Watts TL, Sullivan MH, Counsell SJ, Allsop J, Al-Nakib L, Rutherford MA, Battin M, Roberts I, Edwards AD: Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions. Lancet 2001;358:1699-1700.
53. Minagawa K, Tsuji Y, Ueda H, Koyama K, Tanizawa K, Okamura H, Hashimoto-Tamaoki T: Possible correlation between high levels of IL-18 in the cord blood of pre-term infants and neonatal development of periventricular leukomalacia and cerebral palsy. Cytokine 2002;17:164-170.
54. Dammann O, Leviton A: Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr 2000;12:99-104.
55. Ikegami M, Jobe AH: Postnatal lung inflammation increased by ventilation of preterm lambs exposed antenatally to Escherichia coli endotoxin. Pediatr Res 2002;52:356-362.
56. Faix RG, Donn SM: Association of septic shock caused by early-onset group B streptococcal sepsis and periventricular leukomalacia in the preterm infant. Pediatrics 1985;76:415-419.
57. Wheater M, Rennie JM: Perinatal infection is an important risk factor for cerebral palsy in very-low-birthweight infants. Dev Med Child Neurol 2000;42:364-367.
58. Vermeulen GM, Bruinse HW, Gerards LJ, de Vries LS: Perinatal risk factors for cranial ultrasound abnormalities in neonates born after spontaneous labour before 34 weeks. Eur J Obstet Gynecol Reprod Biol 2001;94:290-295.
59. Hagberg H, Peebles D, Mallard C: Models of white matter injury: Comparison of infectious, hypoxic-ischemic, and excitotoxic insults. Ment Retard Dev Disabil Res Rev 2002;8:30-38.
60. Tasaki K, Ruetzler CA, Ohtsuki T, Martin D, Nawashiro H, Hallenbeck JM: Lipopolysaccharide pre-treatment induces resistance against subsequent focal cerebral ischemic damage in spontaneously hypertensive rats. Brain Res 1997;748:267-270.
61. McElrath TF, Allred EN, Leviton A: Prolonged latency after preterm premature rupture of membranes: An evaluation of histologic condition and intracranial ultrasonic abnormality in the neonate born at <28 weeks of gestation. Am J Obstet Gynecol 2003;189:794-798.
62. Jobe AH: Glucocorticoids, inflammation and the perinatal lung. Semin Neonatol 2001;6:331-342.
63. Gravett MG, Hitti J, Hess DL, Eschenbach DA: Intrauterine infection and preterm delivery: Evidence for activation of the fetal hypothalamic-pituitary- adrenal axis. Am J Obstet Gynecol 2000;182:1404-1413.
64. Watterberg KL, Scott SM, Naeye RL: Chorioamnionitis, cortisol, and acute lung disease in very low birth weight infants. Pediatrics 1997;99:E6.
65. Newnham JP, Moss TJ, Padbury JF, Willet KE, Ikegami M, Ervin MG, Sly P, Jobe A: The interactive effects of endotoxin with prenatal glucocorticoids on short-term lung function in sheep. Am J Obstet Gynecol 2001;185:190-197.
66. Marshall DD, Kotelchuck M, Young TE, Bose CL, Kruyer L, O'Shea TM: Risk factors for chronic lung disease in the surfactant era: A North Carolina population-based study of very low birth weight infants. North Carolina Neonatologists Association. Pediatrics 1999;104:1345-1350.
67. Van Marter LJ, Allred EN, Leviton A, Pagano M, Parad R, Moore M: Antenatal glucocorticoid treatment does not reduce chronic lung disease among surviving preterm infants. J Pediatr 2001;138:198-204.
68. O'Shea TM, Doyle LW: Perinatal glucocorticoid therapy and neurodevelopmental outcome: An epidemiologic perspective. Semin Neonatol 2001;6:291-307.
69. Elimian A, Verma U, Beneck D, Cipriano R, Visintainer P, Tejani N: Histologic chorioamnionitis, antenatal steroids, and perinatal outcomes. Obstet Gynecol 2000;96:333-336.
70. Halliday HL: Postnatal steroids and chronic lung disease in the newborn. Paediatr Respir Rev 2004;5(suppl A):S245-S248.
71. Baud O: Postnatal steroid treatment and brain development. Arch Dis Child Fetal Neonatal Ed 2004;89:F96-F100.
72. Thibeault DW, Emmanouilides GC: Prolonged rupture of fetal membranes and decreased frequency of respiratory distress syndrome and patent ductus arteriosus in preterm infants. Am J Obstet Gynecol 1977;129:43-46.
73. Vergani P, Patane L, Doria P, Borroni C, Cappellini A, Pezzullo JC, Ghidini A: Risk factors for neonatal intraventricular haemorrhage in spontaneous prematurity at 32 weeks gestation or less. Placenta 2000;21:402-407.
74. Salafia CM, Minior VK, Rosenkrantz TS, Pezzulo JC, Popek EJ, Cusick W, Vintzileos AM: Maternal, placental, and neonatal associations with early germinal matrix/intraventricular hemorrhage in infants born before 32 weeks' gestation. Am J Perinatol 1995;6:429-436.
75. Tauscher MK, Berg D, Brockmann M, Seidenspinner S, Speer CP, Groneck P: Association of histologic chorioamnionitis, increased levels of cord blood cytokines, and intracerebral hemorrhage in preterm neonates. Biol Neonate 2003;83:166-170.
76. Resch B, Vollaard E, Maurer U, Haas J, Rosegger H, Müller W: Risk factors and determinants of neurodevelopmental outcome in cystic periventricular leucomalacia. Eur J Pediatr 2000;159:663-670.
77. Dammann O, Allred EN, Veelken N: Increased risk of spastic diplegia among very low birth weight children after preterm labor or prelabor rupture of membranes. J Pediatr 1998;132:531-535.
78. Gray PH, Jones P, O'Callaghan MJ: Maternal antecedents for cerebral palsy in extremely preterm babies: A case-control study. Dev Med Child Neurol 2001;43:580-585.
79. Grether JK, Nelson KB, Walsh E, Willoughby RE, Redline RW: Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants. Arch Pediatr Adolesc Med 2003;157:26-32.
80. Dammann O, Drescher J, Veelken N: Maternal fever at birth and non-verbal intelligence at age nine years in preterm infants. Dev Med Child Neurol 2003;45:184-191.
81. Sarafidis K, Drossou-Agakidou V, Kanakoudi-Tsakalidou F, Taparkou A, Tsakalidis C, Tsandali C, Kremenopoulos G: Evidence of early systemic activation and transendothelial migration of neutrophils in neonates with severe respiratory distress syndrome. Pediatr Pulmonol 2001;31:214-219.
82. Weeks JW, Reynolds L, Taylor D, Lewis J, Wan T, Gall SA: Umbilical cord blood interleukin-6 levels and neonatal morbidity. Obstet Gynecol 1997;90:815-818.
83. Heep A, Behrendt D, Nitsch P, Fimmers R, Bartmann P, Dembinski J: Increased serum levels of interleukin 6 are associated with severe intraventricular haemorrhage in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 2003;88:F501-F504.
84. Bejar R, Wozniak P, Allard M, Benirschke K, Vaucher Y, Coen R, Berry C, Schragg P, Villegas I, Resnik R: Antenatal origin of neurologic damage in newborn infants. I. Preterm infants. Am J Obstet Gynecol 1988;159:357-363.
85. Yoon BH, Romero R, Park JS, Kim M, Oh SY, Kim CJ, Jun JK: The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 2000;183:1124-1129.
86. Mittendorf R, Montag AG, MacMillan W, Janeczek S, Pryde PG, Besinger RE, Gianopoulos JG, Roizen N: Components of the systemic fetal inflammatory response syndrome as predictors of impaired neurologic outcomes in children. Am J Obstet Gynecol 2003;188:1438-1444;discussion 1444-1446.
87. Nelson KB, Grether JK, Dambrosia JM, Walsh E, Kohler S, Satyanarayana G, Nelson PG, Dickens BF, Phillips TM: Neonatal cytokines and cerebral palsy in very preterm infants. Pediatr Res 2003;53:600-607.
88. Van Marter LJ, Dammann O, Allred EN, Leviton A, Pagano M, Moore Martin C, Developmental Epidemiology Network Investigators: Chorioamnionitis, mechanical ventilation, and postnatal sepsis are modulators of chronic lung disease in preterm infants. J Pediatr 2002;140:171-176.