Neuronal nitric oxide synthase (nNOS) catalyzes one-electron reduction of 2,4,6-trinitrotoluene, resulting in decreased nitric oxide production and increased nNOS gene expression: Implication for oxidative stress

Free Radical Biology and Medicine

Volumn 37, Issue 3, 2004, Pages 350-357

  Kumagai, Yoshito ^a   Kikushima, Makoto ^a   Nakai, Yumi ^b   Shimojo, Nobuhiro ^a   Kunimoto, Manabu ^c  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b JEOL LTD   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

(6R) 5,6,7,8 tetrahydro L biopterin; 2,4,6 Trinitrotoluene; BH4; calmodulin; CaM; Cu,Zn SOD; Cu,Zn superoxide dismutase; DCFH DA; Free radicals; Neuronal cells; Neuronal nitric oxide synthase; Nitric oxide; Oxidative stress; Superoxide

Indexed keywords

ARGININE; CALCIUM CHLORIDE; CALMODULIN; CITRULLINE; HYDROGEN PEROXIDE; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE; TRINITROTOLUENE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CEREBELLUM; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; GENE EXPRESSION; MALE; NERVE CELL; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; CELLS, CULTURED; CEREBELLUM; ELECTRONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROGEN PEROXIDE; MALE; NERVE TISSUE PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRINITROTOLUENE;

EID: 3042572345     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.04.023     Document Type: Article

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