Controlled release of biomolecules from pH-sensitive hydrogels prepared by radiation polymerization

Journal of Bioactive and Compatible Polymers

Volumn 19, Issue 3, 2004, Pages 209-220

  Mahkam, Mehrdad ^a  

^a AZARBAIJAN SHAHID MADANI UNIVERSITY   (Iran)

Author keywords

Crosslinking; Drug delivery; Hydrogel; Radiation polymerization; Swelling

Indexed keywords

COPOLYMERIZATION; DERIVATIVES; DRUG PRODUCTS; HYDROGELS; POLYMETHYL METHACRYLATES;

BIOMOLECULES; RADIATION COPOLYMERIZATION;

COPOLYMERS;

2 HYDROXYETHYL METHACRYLATE; METHACRYLIC ACID; TEREPHTHALIC ACID;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED DRUG RELEASE; CROSS LINKING; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; HYDROGEL; HYDROLYSIS; NONHUMAN; PHASE TRANSITION; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RADIATION; STRUCTURE ANALYSIS;

EID: 3042549392     PISSN: 08839115     EISSN: None     Source Type: Journal    
DOI: 10.1177/0883911504044454     Document Type: Article

References (27)

1. Bettini, R., Colombo, P. and Peppas, N. A. (1995). Solubility effects on drug transport though pH-sensitive, swelling-controlled release systems: Transport of theophylline and metoclopramide monohydrochloride, J. Control. Rel., 37: 105-111.
2. Krogars, K., Heinamaki, J., Vesalahti, J., Marvola, M., Antikainen, O., Yliruusi, J., Marvola, M. and Yliruusi, J. (2000). Extrusion-spheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery. Int. J. Pharm., 199: 187-194.
3. Chiu, H. C., Hsiue, G. H., Lee, Y. P. and Huang, L. W. (1999). Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system, J. Biomater. Sci. Polym. Ed., 10: 591-608.
4. Harris, F. W. (1984). Controlled release from polymers containing pendent bioactive substituents, Medical Application of Controlled Release, R. S. Langer, D. L. Wise (Eds), CRC Press, Boca Raton, FL.
5. Wichterle, O. and Lim, D. (1960). Hydrophilic gels for biological use, Nature, 185: 117-118.
6. Mahkam, M., Sharifi, N. and Entezami, A. A. (2000). Regulation of controlled release of ibuprofen from crosslinked polymers containing cubane as a new crosslinking agent, J. Bioact. Comp. Polym., 15: 396-404.
7. Chang, C. H., Sheu, Y. M., Hu, W. P., Wang, L. F. and Chen, J. S. (1998). Synthesis and properties of copolymers from 2-hydroxyethyl methacrylate-linked nonsteroidal anti-inflammatory agents with methacrylic acid, J. Poly. Sci., 36: 1481-1490.
8. Martin, B. D., Linhardt, R. J. and Dordick, J. S. (1998). Highly swelling hydrogels from ordered galactose-based polyacrylates, Biomaterials, 19: 69-76.
9. Cicek, H. and Tuncel, A. (1998). Immobilization of α-chymotrypsin in thermally reversible isopropyl acrylamide-hydroxyethyl methacrylate copolymer gel, J. Polym. Sci., Part A Polym. Chem., 36: 543-552.
10. van Dijk-Wolthuis, W. N. E., Franssen, O., Talsma, H., van Steenbergen, M. J., Kettenes-van den Bosch, J. J. and Hennink, W. E. (1995). Synthesis, characterization and polymerization of glycidyl methacrylate derivatized dextran, Macromolecules, 28: 6317-6322.
11. van Dijk-Wolthuis, W. N. E., Tsang, S. K. Y., Kettenes-van den Bosch, J. J. and Hennink, W. E. (1997). A new class of polymerizable dextranes with hydrolysable goups: Hydroxyethyl methacrylated dextran with and without oligolactate spacer, Polymer, 38: 6235-6242.
12. Joshi, H. N. (1988). Recent advances in drug delivery systems, Polymeric prodrugs, Pharm. Technol., 12: 112.
13. Langer, R. S. and Peppas, N. A. (1981). Present and future applications of biomaterials in controlled drug delivery system, Biomaterials, 2: 201-214.
14. Arshadi, R. (1993). Polymer synthesis via activated esters: A new dimension of creativity in macromolecular chemistry, Adv. Polym. Sci., 111: 1-41.
15. Boudreaux, C. J., Bunyard, W. C. and McCormic, C. L. (1996). Controlled Activity Polymer. VIII. Copolymers of acrylic acid and isomeric N-alkyl acrylamide with pendent b-naphthol ester moieties: Synthesis and hydrolysis, J. Control. Rel., 40: 223-233.
16. Giammona, G., Pitarresi, G., Cavallora, G. and Spadaro, G. (1999). New biodegradable hydrogels based on an acryloylated polyaspartamide crosslinked by gamma irradiation, J. Biomed. Sci. Polym. Ed., 10: 969-987.
17. Jabbari, E. and Nozari, S. (2000). Swelling behavior of acrylic acid hydrogels prepared by -radiation crosslinking of polyacrylic acid in aqueous solution, Eur. Polym. J., 36: 2685-2692.
18. Schoeder, H. and Campbell, D. E. (1972). Absorption, metabolism and excretion of salicylazosulfopyridine in man, Clin. Pharmacol. Ther., 13: 539.
19. Brown, J. P. (1981). Reduction of polymeric azo and nitro dyes by intestinal bacteria, Appl. Environ. Microbiol., 41: 1283.
20. Chung, K. T., Flunk, G. E. and Egan, M. (1976). Azo dye reduction by anaerobes, Appl. Environ. Microbiol., 5: 558.
21. Chourasia, M. K. and Jain, S. K. (2003). Pharmaceutical approaches to colon targeted drug delivery systems, J. Pharm. Pharmaceut. Sci., 6: 33-66.
22. Mahkam, M. and Sharifi, N. (2000). Synthesis and characterization of cubane polyamides, J. Polym. Int., 49: 260-264.
23. D'Alelio, (1964). US Patent, 3145528.
24. Rothenstein, (1979). US patent, 4163681.
25. Iyer, (1982). US Patent, 4343664.
26. Kopeček, J., Kopečková, P., Brøndsted, H., Rathi, R., Řihoá, B., Yeh, P. Y. and Ikesue, K. (1992). Polymers for colon-specific drug delivery, J. Control. Rel., 19: 121-130.
27. Mooter, G. V., Samyn, C. and Kinglet, R. (1994). The relation between swelling properties and enzymatic degadation of azo polymers designed for colon-specific drug delivery, J. Pharm. Res., 11: 12.