Making sense of sex and supplements: Differences in the anticarcinogenic effects of selenium in men and women

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 551, Issue 1-2, 2004, Pages 91-107

  Waters, David J ^a,b   Chiang, Emily C ^b   Cooley, Dawn M ^a,b   Morris, J Steven ^c  

^a Gerald P Murphy Cancer Foundation   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

Cancer incidence; Cancer prevention; Cohort studies; Dietary supplements; Epidemiology; Gender specific risk; Micronutrients; Sex based differences

Indexed keywords

SELENIUM; SELENOMETHIONINE;

ANTINEOPLASTIC ACTIVITY; BLOOD LEVEL; BREAST CANCER; CANCER INCIDENCE; CANCER LOCALIZATION; CANCER MORTALITY; CANCER PREVENTION; CANCER RISK; CARCINOMA; COLORECTAL CANCER; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG MECHANISM; DRUG URINE LEVEL; ESOPHAGUS CANCER; FOLLOW UP; GENOTOXICITY; HUMAN; LUNG CANCER; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; SEX DIFFERENCE; SKIN CANCER; STOMACH CANCER; TISSUE DISTRIBUTION; URINARY EXCRETION; URINARY TRACT CANCER;

ANTICARCINOGENIC AGENTS; FEMALE; HUMANS; MALE; NEOPLASMS; SELENIUM; SEX FACTORS;

EID: 3042545208     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.02.019     Document Type: Review

References (82)

1. Rayman M.P. The importance of selenium to human health. Lancet. 356:2000;233-241
2. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science. 179:1973;588-590
3. Ganther H.E. Selenium metabolism, selenoproteins, and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 20:1999;1657-1666
4. Combs G.F. Jr., Gray W.P. Chemopreventive agents: selenium. Pharmacol. Ther. 79:1998;179-192
5. Ip C., Thompson H.J., Ganther H.E. Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland. Cancer Epidemiol. Biomarkers Prev. 9:2000;49-54
6. Ip C., Hayes C., Budnick R.M., Ganther H.E. Chemical form of selenium, critical metabolites, and cancer prevention. Cancer Res. 51:1991;595-600
7. Vinceti M., Rovesti S., Bergomi M., Vivoli G. The epidemiology of selenium and human cancer. Tumori. 86:2000;105-118
8. M. Garland, M.J. Stampfer, W.C. Willett, D.J. Hunter, The epidemiology of selenium and human cancer, in: B. Frei (Ed.), Natural Antioxidants in Human Health and Disease, Academic Press, 1994, pp. 263-286.
9. Clark L.C., Combs G.F. Jr., Turnbull B.W., Slate E.H., Chalker D.K., Chow J., Davis L.S., Glover R.A., Graham G.F., Gross E.G., Krongrad A., Lesher J.L. Jr., Park H.K., Sanders B.B. Jr., Smith C.L., Taylor J.R. The nutritional prevention of cancer with selenium 1983-1993: a randomized clinical trial. J. Am. Med. Assoc. 276:1996;1957-1963
10. G.F. Combs Jr., J. Lu, Selenium as a cancer prevention agent, in: D.L. Hatfield (Ed.), Selenium, Its Molecular Biology and Role in Human Health, Kluwer Academic Publishers, Norwell, MA, 02061, 2001, pp. 205-217.
11. Kok F.J., deBruijn A.M., Hofman A., Vermeeren R., Valkenburg H.A. Is serum selenium a risk factor for cancer in men only? Am. J. Epidemiol. 125:1987;12-16
12. Salonen J.T., Salonen R., Lappetelainen R., Maenpaa P.H., Alfthan G., Puska P. Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data. Br. Med. J. 290:1985;417-420
13. Willett W.C., Polk B.F., Morris J.S., Stampfer M.J., Pressel S., Rosner B., Taylor J.O., Schneider K., Hames C.G. Prediagnostic serum selenium and risk of cancer. Lancet. 2:1983;130-134
14. T.M. Wizermann, M.L. Pardue (Eds.), Exploring the Biological Contributions to Human Health: Does Sex Matter? National Academy Press, 2001.
15. Pinn V.W. Sex and gender factors in medical studies. J. Am. Med. Assoc. 289:2003;397-400
16. Knekt P., Aromaa A., Maatela J., Alfthan G., Aaran R.K., Hakama M., Hakulinen T., Peto R., Teppo L. Serum selenium and subsequent risk of cancer among Finnish men and women. J. Natl. Cancer Inst. 82:1990;864-868
17. Ringstad J., Jacobsen B.K., Tretli S., Thomassen Y. Serum selenium concentration associated with risk of cancer. Clin. Pathol. 41:1988;454-457
18. Ujiie S., Kikuchi H. The relation between serum selenium value and cancer in Miyagi, Japan: 5-year follow up study. Tohoku J. Exp. Med. 196:2002;99-109
19. Criqui M.H., Bangdiwala S., Goodman D.S., Blaner W.S., Morris J.S., Kritchevsky S., Lippel K., Mebane I., Tyroler H.A. Selenium, retinol, retinol-binding protein, and uric acid. Associations with cancer mortality in a population-based prospective case-control study. Ann. Epidemiol. 1:1991;385-393
20. Kornitzer M., Valente F., De Bacquer D., Neve J., De Backer G. Serum selenium and cancer mortality: a nested case-control study within an age- and sex-stratified sample of the Belgian adult population. Eur. J. Clin. Nutr. 58:2004;98-104
21. Garland M., Morris J.S., Stampfer M.H., Colditz G.A., Spate V.L., Baskett C.K., Rosner B., Speizer F.E., Willett W.C., Hunter D.J. Prospective study of toenail selenium levels and cancer among women. J. Natl. Cancer Inst. 87:1995;497-505
22. van den Brandt P.A., Zeegers M.P.A., Bode P., Goldbohm R.A. Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study. Cancer Epidemiol. Biomarkers Prev. 12:2003;866-871
23. Yoshizawa K., Willett W.C., Morris J.S., Stampfer M.J., Spiegelman D., Rimm E.B., Giovannucci E.J. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J. Natl. Cancer Inst. 90:1998;1219-1224
24. Hartman T.J., Albanes D., Pietinen P., Hartman A.M., Rautalahti M., Tangrea J.A., Taylor P.R. The association between baseline vitamin E, selenium, and prostate cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Cancer Epidemiol. Biomarkers Prev. 7:1998;335-340
25. Goodman G.E., Schaffer S., Bankson D.D., Hughes M.P., Omenn G.S. The Carotene Retinol Efficacy Trial (CARET) Co-Investigators Predictors of serum selenium in cigarette smokers and the lack of association with lung and prostate cancer risk. Cancer Epidemiol. Biomarkers Prev. 10:2001;1069-1076
26. Nomura A.M.Y., Lee J., Stemmermann G.N., Combs G.F. Serum selenium and subsequent risk of prostate cancer. Cancer Epidemiol. Biomarkers Prev. 9:2000;883-887
27. Helzlsouer K.J., Huang H.Y., Alberg A.J., Hoffman S., Burke A., Norkus E.P., Morris J.S., Comstock G.W. Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. J. Natl. Cancer Inst. 92:2000;2018-2023
28. Brooks J.D., Metter E.J., Chan D.W., Sokoll L.J., Landis P., Nelson W.G., Muller D., Anres R., Carter H.B. Plasma selenium level before diagnosis and the risk of prostate cancer development. J. Urol. 166:2001;2034-2038
29. Dorgan J.F., Sowell A., Swanson C.A., Potischman N., Miller R., Schussler N., Stephenson H.E. Relationships of serum carotenoids, retinal, alpha-tocopherol, and selenium with breast caner risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control. 9:1998;89-97
30. van Noord P.A.H., Collette H.J.A., Maas M.J., De Waard F. Selenium levels in nails of premenopausal breast cancer patients assessed prediagnostically in a cohort-nested case-referent study among women screened in the DOM project. Int. J. Epidemiol. 16:1987;318-322
31. van Noord P.A.H., Maas M.J., Van der Tweel I., Collette C. Selenium and the risk of postmenopausal breast cancer in the DOM cohort. Breast Cancer Res. Treat. 25:1993;11-19
32. Overvad K., Wang D.Y., Olsen J., Allen D.S., Thorling E.B., Bulbrook R.D., Hayward J.L. Selenium in human mammary carcinogenesis: a case-cohort study. Eur. J. Cancer. 27:1991;900-902
33. van den Brandt P.A., Goldbohm R.A., van't Veer P., Bode P., Dorant E., Hermus R.J.J., Sturmans F. Toenail selenium levels and the risk of breast cancer. Am. J. Epidemiol. 140:1994;20-26
34. Hunter D.J., Morris J.S., Stampfer M.J., Colditz G.A., Speizer F.E., Willett W.C. A prospective study of selenium status and breast cancer risk. J. Am. Med. Assoc. 264:1990;1128-1131
35. Comstock G.W., Alberg A.J., Huang H.Y., Wu K., Burke A.E., Hoffman S.C., Norkus E.P., Gross M., Cutler R.G., Morris J.S., Spate V.L., Helzlsouer K.J. The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol. Biomarkers Prev. 6:1997;907-916
36. van den Brandt P.A., Goldbohm R.A., van't Veer P., Bode P., Dorant E., Hermus R.J., Sturmans F. A prospective cohort study on selenium status and the risk of lung cancer. Cancer Res. 53:1993;4860-4865
37. van den Brandt P.A., Goldbohm R.A., van't Veer P., Bode P., Dorant E., Hermus R.J.J., Sturmans F. A prospective cohort study on toenail selenium levels and risk of gastrointestinal cancer. J. Natl. Cancer Inst. 85:1993;224-229
38. Burney P.G.J., Comstock G.W., Morris J.S. Serologic precursors of cancer: serum micronutrients and the subsequent risk of pancreatic cancer. Am. J. Clin. Nutr. 49:1989;895-900
39. Duffield-Lillico A.J., Reid M.E., Turnbull B.W., Combs G.F. Jr., Slate E.H., Fischbach L.A., Marshall J.R., Clark L.C. Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol. Biomarkers Prev. 11:2002;630-639
40. Duffield-Lillico A.J., Dalkin B.L., Reid M.E., Turnbull B.W., Slate E.H., Jacobs E.T., Marshall J.R., Clark L.C. Nutritional Prevention of Cancer Study Group Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int. 91:2003;608-612
41. Blot W.J., Li J.Y., Taylor P.R., Guo W., Dawsey S., Wang G.Q., Yang C.S., Zheng S.F., Gail M., Li G.Y., Yu Y., Liu B.Q., Tangrea J., Sun Y.H., Liu F., Fraumeni J.F., Zhang Y.H., Li B. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. Natl. Cancer Inst. 85:1993;1483-1492
42. Mark S.D., Qiao Y.L., Dawsey S.M., Wu Y.P., Katki H., Gunter E.W., Fraumeni J.F., Blot W.J., Dong Z.W., Taylor P.R. Prospective study of serum selenium levels and incident esophageal and gastric cancers. J. Natl. Cancer Inst. 92:2000;1753-1763
43. Zou X.N., Taylor P.R., Mark S.D., Chao A., Wang W., Dawsey S.M., Wu Y.P., Qiao Y.L., Zheng S.F. Seasonal variation of food consumption and selected nutrient intake in Linxian, a high risk area for esophageal cancer in China. Int. J. Vitam. Nutr. Res. 72:2002;375-382
44. Benner S.E., Hong W.K. Clinical chemoprevention: developing a cancer prevention strategy. J. Natl. Cancer Inst. 85:1993;1446-1447
45. Knekt P., Marniemi J., Teppo L., Hellovaara M., Aromaa A. Is low selenium status a risk factor for lung cancer? Am J. Epidemiol. 148:1998;975-982
46. Ratnashinghe D., Tangrea J.A., Forman M.R., Hartman T., Gunter E.W., Qiao Y.L., Yao S.X., Barett M.J., Giffen C.A., Erozan Y., Tockman M.S., Taylor P.R. Serum tocopherols, selenium and lung cancer risk among tin miners in China. Cancer Causes Control. 11:2000;129-135
47. Hartman T.J., Taylor P.R., Alfthan G., Fagerstrom R., Virtamo J., Mark S.D., Virtanen M., Barrett M.J., Albanes D. Toenail selenium concentration and lung cancer in male smokers (Finland). Cancer Causes Control. 13:2002;923-928
48. Virtamo J., Valkeila E., Alfthan G., Punsar S., Huttunen J.K., Karvonen M.J. Serum selenium and risk of cancer: a prospective follow-up of nine years. Cancer. 60:1987;145-148
49. Fex G., Pettersson B., Akesson B. Low plasma selenium as a risk factor for cancer death in middle-aged men. Nutr. Cancer. 10:1987;221-229
50. Nomura A., Heilbrun L.K., Morris J.S., Stemmermann G.N. Serum selenium and the risk of cancer, by specific sites: case-control analysis of prospective data. J. Natl. Cancer Inst. 79:1987;103-108
51. Karagas M.R., Greenberg E.R., Nierenberg D., Stukel T.A., Morris J.S., Stevens M.M., Baron J.A. Risk of squamous cell carcinoma of the skin in relation to plasma selenium, alpha-tocopherol, beta-carotene, and retinol: a nested case-control study. Cancer Epidemiol. Biomarkers Prev. 6:1997;25-29
52. Michaud D.S., Hartman T.J., Taylor P.R., Pietinen P., Alfthan G., Virtamo J., Albanes D. No association between toenail selenium levels and bladder cancer risk. Cancer Epidemiol. Biomarkers Prev. 11:2002;1505-1506
53. Yu M.W., Horng I.S., Hsu K.H., Chiang Y.C., Liaw Y.F., Chen C.J. Plasma selenium levels and risk of hepatocellular carcinoma among men with chronic hepatitis virus infection. Am. J. Epidemiol. 150:1999;367-374
54. Helzlsouer K.J., Alberg A.J., Norkus E.P., Morris J.S., Hoffman S.C., Comstock G.W. Prospective study of serum micronutrients and ovarian cancer. J. Natl. Cancer Inst. 88:1996;32-37
55. Bostick R.M., Potter J.D., McKenzie D.R., Sellers T.A., Kushi L.H., Steinmetz K.A., Folsom A.R. Reduced risk of colon cancer with high intake of vitamin E: the Iowa women's health study. Cancer Res. 53:1993;4230-4237
56. Batieha A.M., Armenian H.K., Norkus E.P., Morris J.S., Spate V.E., Comstock G.W. Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidemiol. Biomarkers Prev. 2:1993;335-339
57. Schober S.E., Comstock G.W., Helsing K.J., Salkeld R.M., Morris J.S., Rider A.A., Brookmeyer R. Serologic precursors of cancer. I. Prediagnostic serum nutrients and colon cancer risk. Am. J. Epidemiol. 126:1987;1033-1041
58. Coates R.J., Weiss N.S., Daling J.R., Morris J.S., Labbe R.F. Serum levels of selenium and retinol and the subsequent risk of cancer. Am. J. Epidemiol. 128:1988;515-523
59. Menkes M.S., Comstock G.W., Vuilleumier J.P., Helsing K.J., Rider A.A., Brookmeyer R. Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. N. Engl. J. Med. 315:1986;1250-1254
60. Helzlsouer K.J., Comstock G.W., Morris J.S. Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Res. 49:1989;6144-6148
61. Zheng W., Blot W.J., Diamond E.L., Norkus E.P., Spate V., Morris J.S., Comstock G.W. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Res. 53:1993;795-798
62. Breslow R.A., Alberg A.J., Helzlsouer K.J., Bush T.L., Norkus E.P., Morris J.S., Spate V.E., Comstock G.W. Serological precursors of cancer: malignant melanoma, basal and squamous cell skin cancer, and prediagnostic levels of retinol, beta-carotene, lycopene, alpha-tocopherol, and selenium. Cancer Epidemiol. Biomarkers Prev. 4:1995;837-842
63. Salonen J.T., Alfthan G., Huttunen J.K., Puska P. Association between serum selenium and the risk of cancer. Am. J. Epidemiol. 120:1984;342-349
64. Wallace K., Byers T., Morris J.S., Cole B.F., Greenberg E.R., Baron J.A., Gudino A., Spate V., Karagas M.R. Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study. Cancer Epidemiol. Biomarkers Prev. 12:2003;464-467
65. Kabuto M., Imai H., Yonezawa C., Neriisi K., Akiba S., Kato H., Suzuki T., Land C.E., Blot W.J. Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan. Cancer Epidemiol. Biomarkers Prev. 3:1994;465-469
66. Peleg I., Morris S., Hames C.G. Is serum selenium a risk factor for cancer? Med. Oncol. Tumor Pharmacother. 2:1985;157-163
67. Zeegers M.P.A., Goldbohm R.A., Bode P., van den Brandt P.A. Prediagnostic toenail selenium and risk of bladder cancer. Cancer Epidemiol. Biomarkers Prev. 11:2002;1292-1297
68. Zang E.A., Wynder E.L. Differences in lung cancer risk between men and women: examination of the evidence. J. Natl. Cancer Inst. 88:1996;183-192
69. Guinee D.G. Jr., Travis W.D., Trivers G.E., et al. Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 antibodies and C-erbB-2 expression. Carcinogenesis. 16:1995;993-1002
70. Mollerup S., Ryberg D., Hewer A., Phillips D.H., Haugen A. Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients. Cancer Res. 59:1999;3317-3320
71. Wei Q., Cheng L., Amos C.I., Wang L.-E., Guo Z., Hong W.K., Spitz M.R. Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. J. Natl. Cancer Inst. 92:2000;1764-1772
72. Morris J.S., Rohan T., Soskolne C.L., Jain M., Horsman T.L., Spate V.L., Baskett C.K., Mason M.M., Nichols T.A. Selenium status and cancer mortality in subjects residing in four Canadian provinces. J. Radioanal. Nuclear Chem. 249:2001;421-427
73. Finley J.W., Kincaid R.L. Effect of sex and time of sampling on selenium and glutathione peroxidase activity in tissues of mature rats. Biol. Trace Elem. Res. 29:1991;181-191
74. NCI, DCPC Chemoprevention Branch and Agent Development Committee, Clinical development plan: l-selenomethionine, J. Cell Biochem. 26S (1996) 202-218.
75. van den Brandt P.A., Goldbohm R.A., van't Veer P., Bode P., Hermus R.J.J., Sturmans F. Predictors of toenail selenium levels in men and women. Cancer Epidemiol. Biomarkers Prev. 2:1993;107-112
76. Swanson C.A., Longnecker M.P., Veillon C., Howe S.M., Levander O.A., Taylor P.R., McAdam P.A., Brown C.C., Stampfer M.J., Willett W.C. Selenium intake, age, gender, and smoking in relation to indices of selenium status of adults residing in a seleniferous area. Am. J. Clin. Nutr. 52:1990;858-862
77. Patterson B., Veillon C.C., Taylor P., Patterson K., Levander O.A. Selenium metabolism in humans differs by gender: results from a stable isotope tracer study. FASEB J. 15:2001;A969
78. Rodrigue Zrodriguez E.M., San Zalaejos M.T., Dia Zromero C. Urinary selenium status of healthy people. Eur. J. Clin. Chem. Clin. Biochem. 33:1995;127-133
79. Kafai M.R., Ganji V. Sex, age, geographical location, smoking, and alcohol consumption influence serum selenium concentrations in the USA: third National Health and Nutrition Examination Survey, 1988-1994. J. Trace Elem. Med. Biol. 17:2003;13-18
80. Waters D.J., Shen S., Cooley D.M., Bostwick D.G., Qian J., Combs G.F. Jr., Glickman L.T., Oteham C., Schlittler D.L., Morris J.S. Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate. J. Natl. Cancer Inst. 95:2003;237-241
81. Mertz W. The essential trace elements. Science. 213:1981;1332-1338
82. Willett W.C., Stampfer M.J. Selenium and human cancer: epidemiological aspects and implications for clinical trials. J. Am. Coll. Toxicol. 5:1986;29-36