Tryptophan at position 104 is involved in transforming light signal into changes of β-sheet structure for the signaling state in the BLUF domain of AppA

Plant and Cell Physiology

Volumn 46, Issue 12, 2005, Pages 1894-1901

  Masuda, Shinji ^a   Hasegawa, Koji ^b,c   Ono, Taka Aki ^b,c  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c RIKEN   (Japan)

Author keywords

AppA; Blue light receptor; BLUF; Flavin; FTIR; Signaling transduction

Indexed keywords

ALANINE; APOPROTEIN; APPA PROTEIN, RHODOBACTER SPHAEROIDES; BACTERIAL PROTEIN; FLAVOPROTEIN; TRYPTOPHAN;

ARTICLE; CHEMISTRY; ESCHERICHIA COLI; GENETICS; INFRARED SPECTROSCOPY; LIGHT; MUTATION; PHOTOTRANSDUCTION; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; TIME; ULTRAVIOLET RADIATION;

ALANINE; APOPROTEINS; BACTERIAL PROTEINS; ESCHERICHIA COLI; FLAVOPROTEINS; LIGHT; MUTATION; PHOTOTRANSDUCTION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TIME FACTORS; TRYPTOPHAN; ULTRAVIOLET RAYS;

EID: 30344475204     PISSN: 00320781     EISSN: 14719053     Source Type: Journal    
DOI: 10.1093/pcp/pci208     Document Type: Article

References (22)

1. Anderson, S., Dragnea, V., Masuda, S., Ybe, J., Moffat, K. and Bauer, C.E. (2005) Structure of a novel photoreceptor, the BLUF domain of AppA from Rhodobacter sphaeroides. Biochemistry 44: 7988-8005.
2. Barth, A. (2000) The infrared absorption of amino acid chains. Prog. Biophys. Mol. Biol. 74: 141-173.
3. Braatsch, S., Gomelsky, M., Kuphal, S. and Klug, G. (2002) A single flavoprotein, AppA, integrates both redox and light signals in Rhodobacter sphaeroides. Mol. Microbiol. 45: 827-836.
4. Fukushima, Y., Okajima, K., Shibata, Y., Ikeuchi, M. and Itoh, S. (2005) Primary intermediate in the photocycle of a blue-light sensory BLUF FAD-protein, Tll0078, of Thermosynechococcus elongatus BP-1. Biochemistry 44: 5149-5158.
5. Gomelsky, M. and Klug, G. (2002) BLUF: a novel FAD-binding domain involved in sensory transduction in microorganisms. Trends Biochem. Sci. 27: 497-500.
6. Han, Y., Braatsch S., Osterloh, L. and Klug, G. (2004) A eukaryotic BLUF domain mediates light-dependent gene expression in the purple bacterium Rhodobacter sphaeroides 2.4.1. Proc. Natl Acad. Sci. USA 101: 12306-12311.
7. Hasegawa, K., Masuda, S. and Ono, T. (2004) Structural intermediate in the photocycle of a BLUF (sensors of blue-light using FAD) protein Slr1694 in a cyanobacterium Synechocystis sp. PCC6803. Biochemistry 43: 14979-14986.
8. Hasegawa, K., Masuda, S. and Ono, T. (2005) Spectroscopic analysis of the dark relaxation process of a photocycle in a sensor of blue-light using FAD (BLUF) protein Slr1694 of the cyanobacterium Synechocystis sp. PCC 6803. Plant Cell Physiol. 46: 136-146.
9. Iseki, M., Matsunaga, S., Murakami, A., Ohno, K., Shiga, K., Yoshida, K., Sugai, M., Takaliashi, T., Hori, T. and Watanabe, M. (2002) A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis. Nature 415: 1047-1051.
10. Kita, A., Okajima, K., Morimoto, Y., Ikeuchi, M. and Miki, K. (2005) Structure of a cyanobacterial BLUF protein, Tll0078, containing a novel FAD-binding blue light sensor domain. J. Mol. Biol. 349: 1-9.
11. Kraft, B.J., Masuda, S., Kikuchi, J., Dragnea, V., Tollin, G., Zaleski, J.M. and Bauer, C.E. (2003) Spectroscopic and mutational analysis of the blue-light photoreceptor AppA: a novel photocycle involving flavin stacking with an aromatic amino acid. Biochemistry 42: 6726-6734.
12. Laan, W., Bednarz, T., Heberle, J. and Hellingwerf, K.J. (2004) Chromophore composition of a heterologously expressed BLUF-domain. Photochem. Photobiol. Sci. 3: 1011-1016.
13. Laan, W., van der Horst, M.A., van Stokkum, I.H. and Hellingwerf, K.J. (2003) Initial characterization of the primary photochemistry of AppA, a blue-light-using flavin adenine dinucleotide-domain containing transcriptional antirepressor protein from Rhodobacter sphaeroides: a key role for reversible intramolecular proton transfer from the flavin adenine dinucleotide chromophore to a conserved tyrosine? Photochem. Photobiol. 78: 290-297.
14. Masuda, S. and Bauer, C.E. (2002) AppA is a blue light photoreceptor that antirepresses photosynthesis gene expression in Rhodobacter sphaeroides. Cell 110: 613-623.
15. Masuda, S. and Bauer, C.E. (2005) The antirepressor AppA uses the novel flavin-binding BLUF domain as blue-light-absorbing photoreceptor to control photosystem synthesis. In Handbook of Photosensory Receptors. Edited by Briggs, W.R. and Spudich, J. pp. 433-445. Wiley-VCH Verlag GmbH, Weinheim.
16. Masuda, S., Hasegawa, K., Ishii, A. and Ono, T. (2004) Light-induced structural changes in a putative blue-light receptor with a novel FAD binding fold sensor of blue-light using FAD (BLUF); Slr1694 of Synechocystis sp. PCC 6803. Biochemistry 43: 5304-5313.
17. Masuda, S., Hasegawa, K. and Ono, T. (2005a) Light-induced structural changes of apoprotein and chromophore in the sensor of blue light using FAD (BLUF) domain of AppA for a signaling state. Biochemistry 44: 1215-1224.
18. Masuda, S., Hasegawa, K. and Ono, T. (2005b) Adenosine diphosphate moiety does not participate in structural changes for the signaling state in the sensor of blue-light using FAD domain of AppA. FEBS Lett. 579: 4329-4332.
19. Masuda, S. and Ono, T. (2005) Comparative spectroscopic studies of sensor of blue-light using FAD (BLUF) proteins, AppA of Rhodobacter sphaeroides and YcgF of Escherichia coli. In Photosynthesis: Fundamental Aspects to Global Perspectives. Vol. II, Edited by van der Est, A. and Bruce, D. pp. 700-702, Allen Press, Lawrence.
20. Okajima, K., Yoshihara, S., Fukushima, Y., Geng, X., Katayama, M., et al. (2005) Biochemical and functional characterization of BLUF-type flavin-binding proteins of two species of cyanobacteria. J. Biochem. 137: 741-750.
21. Rajagopal, S., Key, J.M., Purcell, E.B., Boerema, D.J. and Moffat, K. (2004) Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli. Photochem. Photobiol. 80: 542-547.
22. Socrates, G. (2001) Infrared and Raman Characteristic Group Frequencies, 3rd edn. John Wiley & Sons, Chichester.