Increased expression and function of vascular α1D- adrenoceptors may mediate the prohypertensive effects of angiotensin II

Molecular Interventions

Volumn 5, Issue 6, 2005, Pages 340-342

  Villalobos Molina, Rafael ^a   Ibarra, Maximiliano ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1D ADRENERGIC RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; ENDOTHELIN 1;

ADRENERGIC SYSTEM; BLOOD PRESSURE REGULATION; BLOOD VESSEL; ESSENTIAL HYPERTENSION; HYPERTENSION; MUSCLE HYPERTROPHY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHORT SURVEY; SMOOTH MUSCLE TONE; SPASTICITY; TISSUE REACTION; VASCULAR SMOOTH MUSCLE;

ANGIOTENSIN II; ANIMALS; BLOOD VESSELS; HYPERTENSION; MUSCLE, SMOOTH, VASCULAR; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ADRENERGIC, ALPHA-1; RENIN-ANGIOTENSIN SYSTEM; SIGNAL TRANSDUCTION;

EID: 30344460545     PISSN: 15340384     EISSN: None     Source Type: Journal    
DOI: 10.1124/mi.5.6.6     Document Type: Short Survey

References (22)

1. Weir, M.R. and Dzau, V.J. The renin-angiotensin-aldosterone system: A specific target for hypertension management. Am. J. Hypertens. 12, 205S-213S (1999).
2. Ruiz, P., Basso, N., Cannata, M.A., and Taquini, A.C. The renin-angiotensin system in different stages of spontaneously hypertension in the rat (SHR). Clin. Exp. Hypertension: Theory and Practice A 12, 63-81 (1990).
3. Zicha, J. and Kune, J. Ontogenetic aspects of hypertension development: Analysis in the rat. Physiol. Rev. 79, 1227-1282 (1999).
4. Henrich, W.L. and Levi, M. Ontogeny of renal renin release in spontaneously hypertensive rat and Wistar-Kyoto rat. Am. J. Physiol. 260, F530-F535 (1991).
5. Schiffrin, E.L., Thome, F.S., and Genest, J. Vascular angiotensin II receptors in SHR. Hypertension 6, 682-688 (1984).
6. Van Kleef E.M., Smits, J.F.M., De Mey, J.G.R., Cleutjens, J.P.M., Lombardi, D.M., Schwartz, S.M., and Daemen, M.J.A.P. α1-adrenoceptor blockade reduces the angiotensin II-induced vascular smooth muscle cell DNA synthesis in the rat thoracic aorta and carotid artery. Circ. Res. 70, 1122-1127 (1992).
7. Chen, D.G., Jin, X.Q., Wang, H.J., and Chen, S.C. Mechanisms responsible for sustained hypotension after captopril treatment. J. Hypertension 13, 1113-1121 (1995).
8. Gisbert, R., Ziani, K., Miquel, R., Noguera, M.A., Ivorra, M.D., Anselmi, E., and D'Ocon, P. Pathological role of a constitutively active population of α1D-adrenoceptors in arteries of spontaneously hypertensive rats. Br. J. Pharmacol. 135, 206-216 (2002). This article shows that therapy with captopril (50 mg/kg/day/10 weeks) inhibits the increase in resting tone (IRT) response, a measure of α1D-adrenoceptor constitutive activity, in both WKY and SHR rats and suggests that IRT is not observed because SHR rats did not become hypertensive.
9. Harrap, S.B., Van Der Merge, W.M., Griffin, S.A., MacPherson, F., and Lever, A.F. Brief angiotensin converting enzyme inhibitor treatment in young spontaneously hypertensive rats reduces blood pressure long-term. Hypertension 16, 603-614 (1990).
10. Morton, J.J., Beattie, E.C., and MacPherson, F. Angiotensin II receptor antagonist losartan has persistent effects on blood pressure in the young spontaneously hypertensive rat: Lack of relation to vascular structure. J. Vasc. Res. 29, 264-269 (1992).
11. Paull, J.R.A. and Widdop, R.E. Persistent cardiovascular effects of chonic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats. J. Hypertension 19, 1393-1402 (2001).
12. Bergström, G., Johansson, I., Wickman, A., Gan, L., and Thorup, C. Brief treatment in young spontaneously hypertensive rats abates long-term blood pressure elevation by effects on renal vascular structure. J. Hypertension 20, 1413-1421 (2002).
13. Hu, Z.W., Shi, X.Y., Okazaki, M., and Hoffman, B.B. Angiotensin II induces transcription and expression of alpha-1 adrenergic receptors in vascular smooth muscle cells. Am. J. Physiol. 268, H1006-H1014 (1995). First article to show Ang II-induced α1-adrenoceptor expression, both mRNA and protein, in isolated rat aorta smooth muscle cells.
14. 1D- Adrenergic receptors and mitogen-activated protein kinase mediate increased protein synthesis by arterial smooth muscle. Mol. Pharmacol. 51, 764-775 (1997). The authors report that a1D-adrenoceptor activation is involved in vascular smooth-muscle-cell hypertrophy (a phenomenon observed in hypertension).
15. Villalobos-Molina, R. and Ibarra, M. α1-Adrenoceptors that mediate contraction in arteries of normotensive and spontaneously hypertensive rats are of the α1D or α1A subtypes. Eur. J. Pharmacol. 298, 257-263 (1996). First comparative study of α1-adrenoceptor subtypes present in arteries of SHR and WKY rats.
16. Villalobos-Molina, R. and Ibarra, M. Vascular α1D-Adrenoceptors: are they related to hypertension? Arch. Med. Res. 30, 347-352 (1999).
17. Ibarra, M., López-Guerrero, J.J., and Villalobos-Molina, R. Further evidence of the predominance of α1D-adrenoceptors in arteries of normotensive and spontaneously hypertensive rats. Pharmacol. Rev. Comm. 10, 135-142 (1998). The authors report noradrenaline-induced hypersensitivity in those SHR arteries where α1D-adrenoceptors predominate for contraction (carotid and aorta), compared to WKY. Hypersensitivity is not observed with α1A- or α1A/D-adrenoceptor agonists.
18. Villalobos-Molina, R., López-Guerrero, J.J., and Ibarra, M. Functional evidence of α1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats. Br. J. Pharmacol. 126, 1534-1536 (1999). This article reports the presence of α1D-adrenoceptors in pre-hypertensive SHR, not observed in young normotensive WKY, and suggests their role in the genesis and/or maintenance of high blood pressure.
19. Guimaraes, S. and Moura, D. Vascular adrenoceptors: An update. Pharmacol. Rev. 53, 319-356 (2001).
20. García-Sáinz, J.A. and Villalobos-Molina, R. The elusive α1D-adrenergic receptor: Molecular and cellular characteristics and integrative roles. Eur. J. Pharmacol. 500, 113-120 (2004).
21. Tanoue, A., Nasa, Y., Koshimizu, T., Shinoura, H., Oshikawa, S., Kawai, T., Sunada, S., Takeo, S. and Tsujimoto, G. The α1D-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction. J. Clin. Invest. 109, 765-775 (2002). The authors generated mice lacking (knockout) the α1D-adrenoceptor gene. These knockout mice are hypotensive and their α1D-adrenoceptor-mediated responses are diminished.
22. Lund, A.K., Goens, M.B., Kanagy, N.L., and Walker, M.K. Cardiac hypertrophy in aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1 and mean arterial blood pressure. Toxicol. Applied Pharmacol. 193, 177-187 (2003). The authors report that knockout of the Ahr gene is associated with hypertension: increased angiotensin II and endothelin-1, and cardiac hypertrophy are observed. Captopril treatment for three months decreased: 1) plasma concentrations of Ang II, 2) mean arterial blood pressure (MAP), and 3) heart hypertrophy.