NCX-4016

Drugs of the Future

Volumn 22, Issue 11, 1997, Pages 1231-1233

  Cirino, Giuseppe ^a   Calignano, Antonio ^a   Sannicolò, Franco ^b   Primavera, Angelo ^c   Del Soldato, Piero ^c   Wallace, John L ^d  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c NicOx SA   (France)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; CYCLIC GMP; NONSTEROID ANTIINFLAMMATORY AGENT; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANALGESIA; ANTIINFLAMMATORY ACTIVITY; DOSE RESPONSE; DRUG SAFETY; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; NONHUMAN; SHORT SURVEY; STOMACH INJURY; THROMBOCYTE AGGREGATION;

EID: 0031471385     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (18)

1. Roth, S.H. Nonsteroidal antiinflammatory drugs: Gastropathy, deaths and medical practice. Ann Intern Med 1988, 109: 353-4.
2. Barrier, C.H., Hirschowitz, B.I. Controversies in the detection and management of nonsteroidal antiinflammatory drug-induced side effects of the upper gastrointestinal tract. Arthritis Rheum 1989, 32: 926-32.
3. Patrono, C. Aspirin as anantiplatelet drug. New Engl J Med 1994, 330: 1287-94.
4. Garner, A. Adaptation in the pharmaceutical industry, with particular reference to gastrointestinal drugs and diseases. Scand J Gastroenterol 1992, 27: 83-9.
5. Anti-arthritic medication usage: United States 1991. Stat Bull Metrop Insur Co 1992, 73: 25-34.
6. Wallace, J.L. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years. Gastroenterology 1997, 112: 1000-16.
7. Bloom, D.S. Direct medical costs of disease and gastrointestinal side effects during treatment of arthritis. Amer J Med 1988, 84: 20-4.
8. MacNaughton, W.K., Cirino, G., Wallace, J.L. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci 1989, 45: 1869-76.
9. Lopez-Belmonte, J., Whittle, B.J.R., Moncada, S. The actions of nitric oxide donors in the prevention of injury to the rat gastric mucosa. Brit J Pharmacol 1993, 108: 73-8.
10. Wallace, J.L., Reuter, B., Cicala, C., McKnight, W., Grisham, M.B., Cirino, G. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology 1994, 107: 173-9.
11. Davies, N.M., Roseth, A.G., Appleyard, C.B., McKnight, W., Del Soldato, P., Calignano, A., Cirino, G., Wallace, J.L. NO-naproxen vs naproxen: Ulcerogenic, analgesic and anti-inflammatory effects. Aliment Pharmacol Ther 1997, 11: 69-79.
12. 2 production. Thromb Haemost 1996, 76: 791-8.
13. Wallace, J.L., McKnight, W., Wilson, T.L., Cirino, G., Del Soldato, P., Davies, N.M. Nitric oxide-releasing aspirin derivative (NCX-4016): A gastric-sparing antithrombotic drug. Gastroenterology 1997, 112: A325.
14. Smith, S.M., Holm-Rutili, L., Perry, A.M., Grisham, M.B., Artors, K.-E., Granger, D.N., Kvietys, P.R. Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat. Gastroenterology 1987, 93: 466-71.
15. Andrews, F.J., Malcontenti-Wilson, C., O'Brien, P.E. Polymorphonuclear leukocyte infiltration into gastric mucosa after ischemia reperfusion. Amer J Physiol 1994, 266: G48-54.
16. Wallace, J.L., McKnight, W., Wilson, T.W., Del Soldato, P., Cirino, G. Reduction of hemorrhagic shock-induced gastric damage by an nitric oxide-releasing aspirin derivative: Role of neutrophils. Amer J Physiol 1997, in press.
17. Data on file. RBM SpA. Exp. No. 960096, July 18, 1996.
18. Data on file. RBM SpA. Exp. No. 960090, Dec. 4, 1996.