Involvement of calcium in pain and antinociception

Brazilian Journal of Medical and Biological Research

Volumn 34, Issue 4, 2001, Pages 449-461

  Prado, W A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Analgesia; Antinociception; Calcium antagonists; Calcium ions; Opioids

Indexed keywords

AMIKACIN; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; CINNARIZINE; DILTIAZEM; FLUNARIZINE; GENTAMICIN; NEOMYCIN; NICARDIPINE; NIFEDIPINE; NIMODIPINE; OMEGA AGATOXIN; OMEGA CONOTOXIN; OMEGA CONOTOXIN MVIIA; OPIATE; SNX 159; SNX 239; UNCLASSIFIED DRUG; VERAPAMIL;

ANALGESIA; ANTINOCICEPTION; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; DRUG SAFETY; NEUROTRANSMITTER RELEASE; NOCICEPTION; NONHUMAN; PAIN; PATHOPHYSIOLOGY; REVIEW; TAIL FLICK TEST;

EID: 0035004412     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2001000400003     Document Type: Review

References (60)

1. Zamponi GW & Snutch TP (1998). Modulation of voltage-dependent calcium channels by G proteins. Current Opinion in Neurobiology, 8: 351-356.
2. 2+ signaling requirements. Biochemical Journal, 337: 153-169.
3. Rego EM, Corrado AP & Prado WA (1992). Antinociception induced by intracerebroventricular or intrathecal administration of gentamicin in rats. General Pharmacology, 23: 481-485.
4. Pichler M, Wang ZY, Grabner-Weiss C, Reimer D, Hering S, Grabner M, Glossmann H & Striessnig J (1996). Block of P/ Q-type calcium channels by therapeutic concentrations of aminoglycoside antibiotics. Biochemistry, 35: 14659-14664.
5. Venegas H & Schaible HG (2000). Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia. Pain, 85: 9-18.
6. Smith FL & Dewey WL (1992). Evidence that endogenous opioids mediate the antinociceptive effects of intrathecally administered calcium in mice. Journal of Pharmacology and Experimental Therapeutics, 262: 995-1003.
7. Coderre TJ & Melzack R (1992). The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury. Journal of Neuroscience, 12: 3671-3675.
8. Ferreira SH & Nakamura M (1979). II -Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins, 18: 191-200.
9. Ben Sreti MM, Gonzalez JP & Sewell RDE (1983). Effects of elevated calcium and calcium antagonists on 6,7-benzomorphan-induced analgesia. European Journal of Pharmacology, 90: 385-391.
10. Smith FL & Stevens DL (1995). Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium. Journal of Pharmacology and Experimental Therapeutics, 272: 290-299.
11. Harris RA, Loh HH & Way EL (1975). Effects of divalent cations, cation chelators and an ionophore on morphine analgesia and tolerance. Journal of Pharmacology and Experimental Therapeutics, 195: 488-498.
12. Dogrul A & Yesilyurt O (1998). Effects of intrathecally administered aminoglycoside antibiotics, calcium-channel blockers, nickel and calcium on acetic acid-induced writhing test in mice. General Pharmacology, 30: 613-616.
13. Quijada L, Germany A, Hernández A & Contreras E (1992). Effects of calcium channel antagonists and BAY K 8644 on the analgesic response to pentazocine and U 50488H. General Pharmacology, 23: 837-842.
14. Kuzmin AV, Patkina NA & Zvartau EE (1994). Analgesic and reinforcing effects of morphine in mice. Influence of Bay K-8644 and nimodipine. Brain Research, 652: 1-8.
15. Hoffmeister F & Tettenborn D (1986). Calcium agonists and antagonists of the dihydropyridine type: antinociceptive effects, interference with opiate-μ-receptor agonists and neuropharmacological actions in rodents. Psychopharmacology, 90: 299-307.
16. Dierssen M, Flórez J & Hurlé MA (1990). Calcium channel modulation by dihydropyridines modifies sufentanil-induced antinociception in acute and tolerant conditions. Naunyn-Schmiedeberg's Archives of Pharmacology, 342: 559-565.
17. Schmidt WK & Way EL (1980). Hyperalgesic effects of divalent cations and antinociceptive effects of a calcium chelator in naive and morphine-dependent mice. Journal of Pharmacology and Experimental Therapeutics, 212: 22-27.
18. Malmberg AB & Yaksh TL (1994). Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N-and P-type channels inhibits formalin-induced nociception. Journal of Neuroscience, 14: 4882-4890.
19. Weissman R, Gestslev V, Pankova IA, Schrieber S & Pick CG (1999). Pharmacological interaction of the calcium channel blockers verapamil and flunarizine with the opioid system. Brain Research, 818: 187-195.
20. Miranda HF, Pelissier T & Sierralta F (1993). Analgesic effects of intracerebroventricular administration of calcium channel blockers in mice. General Pharmacology, 24: 201-204.
21. Del Pozo E, Ruiz-Garcia C & Baeyens JM (1990). Analgesic effects of diltiazem and verapamil after central and peripheral administration in the hot-plate test. General Pharmacology, 21: 681-685.
22. Contreras E, Tamayo L & Amigo M (1988). Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance. European Journal of Pharmacology, 148: 463-466.
23. Al-Humayyd MS (1991). Effect of diltiazem, nifedipine and verapamil on the antinociceptive action of acetylsalicylic acid in mice. General Pharmacology, 22: 121-125.
24. 2+ channel blockers. European Journal of Pharmacology, 217: 137-141.
25. Benedek G & Sziksay M (1984). Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists. Pharmacological Research Communications, 16: 1009-1018.
26. Chaplan SR, Pogrel JW & Yaksh TL (1994). Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. Journal of Pharmacology and Experimental Therapeutics, 269: 1117-1123.
27. Omote K, Sonoda H, Kawamata M, Iwasaki H & Namiki A (1993). Potentiation of antinociceptive effects of morphine by calcium-channel blockers at the level of the spinal cord. Anesthesiology, 79: 746-752.
28. Spampinato S, Speroni E, Govoni P, Pistacchio E, Romagnoli C, Murari G & Ferri S (1994). Effect of ω-conotoxin and verapamil on antinociceptive, behavioural and thermoregulatory responses to opioids in the rat. European Journal of Pharmacology, 254: 229-238.
29. Diaz A & Dickenson AH (1997). Blockade of spinal N- and P-type, but not L-type, calcium channels inhibits the excitability of rat dorsal horn neurones produced by subcutaneous formalin inflammation. Pain, 69: 93-100.
30. Carta F, Bianchi M, Argenton S, Cervi D, Marolla G, Tamburini M, Breda M, Fantoni A & Penerai AE (1990). Effect of nifedipine on morphine-induced analgesia. Anesthesia and Analgesia, 70: 493-498.
31. Wong CH, Dey P, Yarmush J, Wu WH & Zbuzek VK (1994). Nifedipine-mduced analgesia after epidural injection in rats. Anesthesia and Analgesia, 79: 303-306.
32. Rego EM, Corrado AP & Prado WA (1990). Antinociceptive effects of calcium channel blockers in the rat. Brazilian Journal of Medical and Biological Research, 23: 297-305.
33. Barro M, Ruiz F & Hurlé MA (1995). κ-Opioid receptor mediated antinociception in rats is dependent on the functional state of dihydropyridine-sensitive calcium channels Brain Research, 672: 148-152.
34. Lia EM & Prado WA (1999). Effects of intrathecal L- and N-type calcium channel blockers on the antinociception evoked by opioid agonists in the rat tail flick test. Acta Physiologica, Pharmacologica et Therapeutica Latinoamericana, 49: 195-203.
35. Malmberg AB & Yaksh TL (1995). Effect of continuous intrathecal infusion of ω-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain, 60: 83-90.
36. Corrado AP, Pimenta de Morais I & Prado WA (1989). Aminoglycoside antibiotics as a tool for the study of the biological role of calcium ions. Acta Physiologica et Pharmacologica Latioamericana, 39: 419-430.
37. Prado WA, Tonussi CR, Rego EM & Corrado AP (1990). Antinociception induced by intraperitoneal injection of gentamicin in rats and mice. Pain, 41: 365-371.
38. Basilico L, Parolaro D, Rubino T, Gori E & Giagnoni G (1992). Influence of ω-conotoxin on morphine analgesia and withdrawal syndrome in rats. European Journal of Pharmacology, 218: 75-81.
39. Wang YX, Pettus M, Gao D, Phillips C & Bowersox SS (2000). Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain. Pain, 84: 151-158.
40. Bowersox SS, Gadbois T, Singh T, Pettus M, Wang YX & Luther RR (1996). Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain. Journal of Pharmacology and Experimental Therapeutics, 279: 1243-1249.
41. Wang YX, Gao D, Pettus M, Phillips C & Bowersox SS (2000). Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. Pain, 84: 271-281.
42. Ocaña M & Baeyens JM (1991). Analgesic effects of centrally administered aminoglycoside antibiotics in mice. Neuroscience Letters, 126: 67-70.
43. Atamer-Simsek S, Ölmez-Salvarli H, Güç O & Eroglu L (2000). Antinociceptive effect of amikacin and its interaction with morphine and naloxone. Pharmacological Research, 41: 355-360.
44. Law PY & Loh HH (1999). Regulation of opioid receptor activities. Journal of Pharmacology and Experimental Therapeutics, 289: 607-624.
45. Besson JM & Chaouch A (1987). Peripheral and spinal mechanisms of nociception. Pharmacological Reviews, 67: 67-185.
46. Guerrero-Muñoz F & Fearon Z (1982). Opioids/opiates analgesic response modified by calcium. Life Sciences, 31: 1237-1240.
47. Díaz A, Flórez J, Pazos A & Hurlé MA (2000). Opioid tolerance and supersensitivity induce regional changes in the autoradiographic density of dihydropyridine-sensitive calcium channels in the rat central nervous system. Pain, 86: 227-235.
48. 2+ channel antagonists on morphine analgesia, tolerance and dependence, and on blood pressure in the rat. European Journal of Pharmacology, 352: 189-197.
49. Taddese A, Nah SY & McCleskey EW (1995). Selective opioid inhibition of small nociceptive neurons. Science, 270: 1366-1369.
50. Bormann BV, Boldt J, Sturm G, Kling D, Weidler B, Lohmann E & Hempelmann G (1985). Calciumantagonisten in der Anästhesie, Additive Analgesie durch Nimodipin während cardiochirurgischer Eingriffe. Anaesthesist, 34: 429-434.
51. Lehman KA, Kriegel R & Ueki M (1989). Zur klinischen Bedeutung von Arzneimittelinteraktionen zwischen Opaiten und Kalziumantagonisten. Eine randomisierte Doppeblindstudie mit Fentanyl und Nimodipin im Rahmen der postoperativen intravenösen On-Demand Analgesie. Anaesthesist, 38: 110-115.
52. Garcia LV (1995). Efeito da nifedipina na analgesia induzida pelo fentan I. Doctoral thesis, Faculdade de Medicina de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil.
53. Pereira IT, Prado WA & Dos Reis MP (1993). Enhancement of the epidural morphine-induced analgesia by systemic nifedipine. Pain, 53: 341-355.
54. Prough DS, McLeskey CH, Poehling GG, Koman LA, Weeks DB, Whitworth T & Semble EL (1985). Efficacy of oral nifedipine in the treatment of reflex sympathetic dystrophy. Anesthesiology, 62: 796-799.
55. Roca G, Aguilar JL, Gomar C, Mazo V, Costa J & Vidal F (1996). Nimodipine fails to enhance the analgesic effect of slow release morphine in the early phases of cancer pain treatment. Pain, 68: 239-243.
56. Santillán R, Maestre JM, Hurlé MA & Flórez J (1994). Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report. Pain, 58: 129-132.
57. Lima ICPR (1996). Efeito da nifedipina na analgesia de pacientes com dor crônica neoplásica em uso de morfina. Master's thesis, Faculdade de Medicina de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil.
58. Brose WG, Gutlove DP, Luther RR, Bowersox SS & McGuire D (1997). Use of intrathecal ziconotide, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain. Clinical Journal of Pain, 13: 256-257.
59. Atanassoff PG, Hartmannsgruber MWB, Thrasher J, Wermeling D, Longton W, Gaeta R, Singh T, Mayo M, McGuire D & Luther RR (2000). Ziconotide, a new N-type calcium channel blocker, administered intrathecally for postoperative pain. Regional Anesthesia and Pain Medicine, 23: 274-278.
60. Penn RD & Paice JA (2000). Adverse effects associated with the intrathecal administration of ziconotide. Pain, 85: 291-296.