Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans

Biochemical Journal

Volumn 379, Issue 1, 2004, Pages 191-198

  Fei, You Jun ^a   Liu, Jin Cai ^a   Inoue, Katsuhisa ^a   Zhuang, Lina ^a   Miyake, Katsuya ^a   Miyauchi, Seiji ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Body size; Caenorhabditis elegans; Fat synthesis; Life span; RNA interference (RNAi); Sodium coupled citrate transporter

Indexed keywords

ABSORPTION; ACIDS; BIOSYNTHESIS; CHOLESTEROL; CLONING; DIGESTIVE SYSTEM; FATTY ACIDS; GENES; NUTRITION; RNA;

ELECTROGENICS; HOMOLOGY; VOLTAGE CLAMP;

BIOCHEMISTRY;

CHOLESTEROL; CITRIC ACID; DICARBOXYLIC ACID; FATTY ACID; SODIUM; SUCCINIC ACID; TRICARBOXYLIC ACID;

ABSORPTION; ARTICLE; BIOSYNTHESIS; BODY SIZE; CAENORHABDITIS ELEGANS; CELL LINE; CITRIC ACID CYCLE; CLONING; DIGESTION; DROSOPHILA; ENERGY RESOURCE; FAT CONTENT; GENE EXPRESSION; GENE FUSION; HUMAN; HUMAN CELL; INTESTINE; LIFESPAN; MAMMAL; METABOLISM; NONHUMAN; NUTRIENT; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REPORTER GENE; RNA INTERFERENCE; SEQUENCE HOMOLOGY; STATISTICAL SIGNIFICANCE; VOLTAGE CLAMP; XENOPUS;

ADIPOSE TISSUE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOLOGICAL TRANSPORT; BODY COMPOSITION; BODY CONSTITUTION; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE; CITRIC ACID; CITRIC ACID CYCLE; CLONING, MOLECULAR; GENES, HELMINTH; GENES, REPORTER; HUMANS; INTESTINES; LONGEVITY; MOLECULAR SEQUENCE DATA; OOCYTES; ORGAN SPECIFICITY; ORGANIC ANION TRANSPORTERS; PATCH-CLAMP TECHNIQUES; PIGMENT EPITHELIUM OF EYE; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SODIUM; XENOPUS LAEVIS;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA; MAMMALIA;

EID: 1842844288     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031807     Document Type: Article

References (37)

1. Fei, Y. J., Inoue, K. and Ganapathy, V. (2003) Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. J. Biol. Chem. 278, 6136-6144
2. Markovich, D. and Murer, H. (2004) The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch. Eur. J. Physiol., in the press
3. Pajor, A. M. (1995) Sequence and functional characterization of a renal sodium/ dicarboxylate cotransporter. J. Biol. Chem. 270, 5779-5785
4. +-dicarboxylate cotransporters, NaDC-1 and hNaDC-1. Am. J. Physiol. 271, F1093-F1099
5. +-dependent dicarboxylate transporter. Am. J. Physiol. 273, G267-G274
6. +-dicarboxylate transporter. Am. J. Physiol. 275, F298-F305
7. +-dicarboxylate cotransporter. J. Biol. Chem. 273, 20972-20981
8. Kekuda, R., Wang, H., Huang, W., Pajor, A. M., Leibach, F. H., Devoe, L. D., Prasad, P. D. and Ganapathy, V. (1999) Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter. J. Biol. Chem. 274, 3422-3429
9. Chen, X., Tsukaguchi, H., Chen, X. Z., Berger, U. V. and Hediger, M. A. (1999) Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter. J. Clin. Invest. 103, 1159-1168
10. Pajor, A. M. and Sun, N. N. (2000) Molecular cloning, chromosomal organization, and functional characterization of a sodium-dicarboxylate cotransporter from mouse kidney. Am. J. Physiol. Renal Physiol. 279, F482-F490
11. +-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain. J. Pharmacol. Exp. Ther. 295, 392-403
12. +-dependent high-affinity dicarboxylate transporter. Am. J. Physiol. Cell Physiol. 278, C1019-C1030
13. Rogina, B., Reenan, R. A., Nilsen, S. P. and Helfand, S. L. (2000) Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290, 2137-2140
14. Inoue, K., Fei, Y. J., Huang, W., Zhuang, L., Chen, Z. and Ganapathy, V. (2002) Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates. Biochem. J. 367, 313-319
15. Knauf, F., Rogina, B., Jiang, Z., Aronson, P. S. and Helfand, S. L. (2002) Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proc. Natl. Acad. Sci. U.S.A. 99, 14315-14319
16. Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. and Ganapathy, V. (2002) Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain. J. Biol. Chem. 277, 39469-39476
17. +-coupled citrate transporter: primary structure, genomic organization, and transport function. Biochem. Biophys. Res. Commun. 299, 465-471
18. Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. and Ganapathy, V. (2003) Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. Biochem. J. 374, 21-26
19. Sulston, J. and Hodgkin, J. (1988) Methods. In The Nematode Caenorhabditis elegans (Wood, W. B. and the community of C. elegans researchers, eds.), pp. 587-606, Cold Spring Harbor Press, Cold Spring Harbor, NY
20. Lewis, J. A. and Fleming, J. T. (1995) Basic culture methods. Methods Cell Biol. 48, 3-29
21. Fei, Y. J., Fujita, T., Lapp, D. F., Ganapathy, V. and Leibach, F. H. (1998) Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression. Biochem. J. 332, 565-572
22. + channel and an exclusive expression in neurons. J. Biol. Chem. 275, 9563-9571
23. Fei, Y. J., Kanai, Y., Nussberger, S., Ganapathy, V., Leibach, F. H., Romero, M. F., Singh, S. K., Boron, W. F. and Hediger, M. A. (1994) Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature (London) 368, 563-566
24. +/oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical electrogenic properties. Biochim. Biophys. Acta 1284, 125-128
25. Mello, C. and Fire, A. (1995) DNA transformation. Methods Cell Biol. 48, 451-482
26. Kramer, J. M., French, R. P., Park, E. C. and Johnson, J. J. (1990) The Caenorhabditis elegans roi-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen. Mol. Cell Biol. 10, 2081-2089
27. Miller, D. M. and Shakes, D. C. (1995) Immunofluorescence microscopy. Methods Cell Biol. 48, 365-394
28. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. W. and Prasher, D. C. (1994) Green fluorescent protein as a marker for gene expression. Science 263, 802-805
29. Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E. and Mello, C. C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (London) 391, 806-811
30. Timmons, L., Court, D. L. and Fire, A. (2001) Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263, 103-112
31. McCulloch, D. and Gems, D. (2003) Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans. Exp. Gerontol. 38, 129-136
32. Greenspan, P., Mayer, E. P. and Fowler, S. D. (1985) Nile red: a selective fluorescent stain for intracellular lipid droplets. J. Cell Biol. 100, 965-973
33. Ashrafi, K., Chang, F. Y., Watts, J. L., Fraser, A. G., Kamath, R. S., Ahringer, J. and Ruvkun, G. (2003) Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature (London) 421, 268-272
34. Kenyon, C., Chang, J., Gensch, E., Rudner, A. and Tabtiang, R. (1993) A C. elegans mutant that lives twice as long as wild type. Nature (London) 366, 461-464
35. Wolkow, C. A., Kimura, K. D., Lee, M. S. and Ruvkun, G. (2000) Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290, 147-150
36. Krebs, H. A. (1950) Chemical composition of blood plasma and serum. Annu. Rev. Biochem. 19, 409-430
37. Nordmann, J. and Nordmann, R. (1961) Organic acids in blood and urine. Adv. Clin. Chem. 4, 53-120