Noradrenergic modulation of space exploration in visual neglect

Annals of Neurology

Volumn 59, Issue 1, 2006, Pages 186-190

  Malhotra, Paresh A ^a,b   Parton, Andrew D ^a,b   Greenwood, Richard ^a,c   Husain, Masud ^a,b  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; GUANFACINE; PLACEBO;

ARTICLE; ATTENTION; CASE REPORT; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; NEUROPHARMACOLOGY; NORADRENERGIC SYSTEM; PREFRONTAL CORTEX; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RIGHT HEMISPHERE; STROKE; VISUAL DEPRIVATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ATTENTION; CEREBROVASCULAR ACCIDENT; GUANFACINE; HUMANS; NEUROPSYCHOLOGICAL TESTS; NOREPINEPHRINE; PERCEPTUAL DISORDERS; SPACE PERCEPTION; VISUAL PERCEPTION;

EID: 29944436174     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.20701     Document Type: Article

References (20)

1. De Renzi E. Disorders of space exploration and cognition. New York: Wiley, 1982.
2. Mesulam MM. A cortical network tor directed attention and unilateral neglect. Ann Neurol 1981;10:309-325.
3. Husain M, Rorden C. Non-spatially lateralized mechanisms in hemispatial neglect. Nat Rev Neurosci 2003;4:26-36.
4. Robertson IH. Do we need the "lateral" in unilateral neglect? Spatially nonselective attention deficits in unilateral neglect and their implications for rehabilitation. Neuroimage 2001;14:S85-S90.
5. Heilman KM, Schwartz HD, Watson RT. Hypoarousal in patients with the neglect syndrome and emotional indifference. Neurology 1978;28:229-232.
6. Robertson IH, Manly T, Beschin N, et al. Auditory sustained attention is a marker of unilateral spatial neglect. Neuropsychologia 1997;35:1527-1532.
7. Robertson IH, Mattingley JB, Rorden C, Driver J. Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness. Nature 1998;395:169-172.
8. Hillis AE, Newhart M, Heidler J, et al. Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke. J Neurosci 2005;25:3161-3167.
9. Pardo JV, Fox PT, Raichle ME. Localization of a human system for sustained attention by positron emission tomography. Nature 1991;349:61-64.
10. Pans TS, Zatorre RJ, Hofle N, et al. Time-related changes in neural systems underlying attention and arousal during the performance of an auditory vigilance task. J Cogn Neurosci 1997;9:392-408.
11. Posner MI, Petersen SE. The attention system of the human brain. Annu Rev Neurosci 1990;13:25-42.
12. Coull JT. Neural correlates ol attention and arousal: insights trom electrophysiology, functional neuroimaging and psychopharmacology. Prog Neurobiol 1998;55:343-361.
13. Wilkins AJ, Shallice T, McCarthy R. Frontal lesions and sustained attention. Neuropsychologia 1987;25:359-365.
14. Smith A, Nutt D. Noradrenaline and attention lapses. Nature 1996;380:291.
15. Jakala P, Riekkmen M, Sirvio J, et al. Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neuropsychopharmacology 1999;20:460-470.
16. Arnsten AFT, Robbins TW. Neurochemical modulation of prefrontal cortical function in humans and animals. In: Stuss DT, Knight RT, eds. Principles of frontal lobe function. New York: Oxford University Press; 51-84, 2002.
17. Avery RA, Eranowicz JS, Studholme C, et al. The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task. Neuropsychopharmacology 2000;23:240-249.
18. Malhotra P, Jager HR, Parton A, et al. Spatial working memory capacity in unilateral neglect. Brain 2005;128:424-435.
19. Arnsten AF, Cai JX, Goldman-Rakic PS. The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. J Neurosci 1988;8:4287-4298.
20. Wojciulik E, Rorden C, Clarke K, et al. Group study of an "undercover" test for visuospatial neglect: invisible cancellation can reveal more neglect than standard cancellation. J Neurol Neurosurg Psychiatry 2004;75:1356-1358.