A very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor

Tetrahedron

Volumn 62, Issue 6, 2006, Pages 1110-1115

  Zhao, Matthew ^a   Yin, Jingjun ^a   Huffman, Mark A ^a   McNamara, James M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aminothiazole; Chloropyridine; KDR; Pd catalysis; Piperazine; Xantphos

Indexed keywords

ALDEHYDE; AMINOTHIADIAZOLE; N (1,3 THIAZOL 2 YL)PYRIDIN 2 AMINE; PIPERAZINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR;

ARTICLE; ARYLATION; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CATALYST; CRYSTALLIZATION; DRUG SYNTHESIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 29744465320     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2005.10.081     Document Type: Article

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