Effects of X-linked inhibitor of apoptosis protein and pro-apoptotic protein Smac on apoptosis regulation in response to chemotherapies in pancreatic carcinoma cells

Chinese Journal of Microbiology and Immunology

Volumn 25, Issue 10, 2005, Pages 794-798

  Du, Ji Hui ^a   Zhang, Hou De ^b   Lei, Ping ^b   Su, Zhuo Wa ^b   Mai, Li Wen ^b   Zheng, Fang ^b   Gong, Fei Li ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NONE

Author keywords

Apoptosis; Pancreatic carcinoma; Second mitochondria derived activator of caspase direct IAP binding protein with low PI(Samc DIABLO); X linked inhibitor of apoptosis protein (XIAP)

Indexed keywords

CASPASE 3; CISPLATIN; FLUOROURACIL; PLASMID VECTOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CARCINOMA CELL; CELL MATURATION; CELL MEMBRANE PERMEABILITY; CELL PERMEABILIZATION; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; DRUG EFFECT; DRUG RESPONSE; DRUG SENSITIVITY; DRUG TARGETING; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE CONSTRUCT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MITOCHONDRION; PANCREAS CARCINOMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECOMBINANT PLASMID; REGULATORY MECHANISM; SENSITIZATION; UPREGULATION; WESTERN BLOTTING;

EID: 29744464351     PISSN: 02545101     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Igney FH, Krammer PH. Death and anti-death: Tumour resistance to apoptosia. Nature Reviews, 2002, 2: 277-288.
2. Kalthoff H, Westphal S. Apoptosis: Targets in pancreatic cancer. Molecular Cancer, 2003, 2: 1-14.
3. Ferreira CG, van der Valk P, Span SW, et al. Assessment of IAP(inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small cell lung cancer patients. Ann Oncol, 2001, 12: 799-805.
4. Li J, Feng Q, Kim JM, et al. Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins. Endocrinology, 2001, 142: 370-380.
5. Verhagen AM, Ekert PG, Pakusch M, et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell, 2000, 102: 43-53.
6. Deveraux QL, Reed JC. IAP family proteins-suppressors of apoptosis. Genes Dev, 1999, 13: 239-252.
7. Trauzold A, Schmiedel S, Röder C, et al. Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells. Br J Cancer, 2003, 89: 1714-1721.
8. Yang L, Cao ZH, Yan H, et al. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: Implication for cancer specific therapy. Cancer Res, 2003, 63: 6815-6824.
9. Guo F, Nimmanapalli R, Paranawithana S. Ecotopic overexpression of second mitochondria-derived activator of caspases(Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothiline B derivative-( BMS 247550) and Apo-2L/TRAIL-induced apoptosis. Blood, 2002, 99: 3419-3426.
10. Fulda S, Wick W, Weller M, et al. Smac agonists sensitize for Apo2L/ TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med, 2002, 8: 808-815.
11. Hinz S, Trauzold A, Boenicke L, et al. Bcl-xL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. Oncogene, 2000, 19: 5477-5486.