Neurophysiological investigation of hepatic encephalopathy

Metabolic Brain Disease

Volumn 20, Issue 4, 2005, Pages 369-379

  Amodio, Piero ^a,b   Gatta, Angelo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Clinica Medica2   (Italy)

Author keywords

Brainstem acoustic evoked potentials; EEG; Evoked potentials; Hepatic encephalopathy; P300; Somatosensory evoked potentials; Visual evoked potentials

Indexed keywords

COMATOSE PATIENT; CONFERENCE PAPER; CONFUSION; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; DIAGNOSTIC PROCEDURE; DISEASE SEVERITY; ELECTROENCEPHALOGRAM; EVOKED BRAIN STEM AUDITORY RESPONSE; EVOKED RESPONSE; EVOKED SOMATOSENSORY RESPONSE; EVOKED VISUAL RESPONSE; HEPATIC ENCEPHALOPATHY; HUMAN; LIVER DISEASE; MENTAL DISEASE; NEUROPHYSIOLOGY; PATIENT MONITORING; PROGNOSIS; QUALITY CONTROL; TREATMENT OUTCOME;

ELECTROENCEPHALOGRAPHY; HEPATIC ENCEPHALOPATHY; HUMANS; LIVER DISEASES; PROGNOSIS;

EID: 29744456064     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-005-7921-5     Document Type: Conference Paper

References (76)

1. Amodio, P., Quero, J.C., Del Piccolo, F., Gatta, A., and Schalm, S.W. (1996). Diagnostic tools for the detection of subclinical hepatic encephalopathy: Comparison of standard and computerized psychometric tests with spectral-EEG. Metab. Brain Dis. 11:315-327.
2. Amodio, P., Marchetti, P., Del Piccolo, F., de Tourtchaninoff, M., Varghese, P., Zuliani, C., Campo, G., Gatta, A., and Guerit, J.M. (1999). Spectral versus visual EEG analysis in mild hepatic encephalopathy. Clin. Neurophysiol. 110:1334-1344.
3. Amodio, P., Del Piccolo, F., Petteno, E., Mapelli, D., Angeli, P., Iemmolo, R., Muraca, M., Musto, C., Gerunda, G., Rizzo, C., Merkel, C., and Gatta, A. (2001). Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients J. Hepatol. 35:37-45.
4. Amodio, P., Baraldi, M., Burra, P., La Villa, G., Loguercio, C., Marchesini, G., Marra, F., Merli, M., Moroni, F., Salerno, F., Riggio, O., and Zeneroli, M. L. (2004a). Linea guida dell'Associazione Italiana per lo Studio del Fegato (AISP) sulla diagnosi e la terapia della encefalopatia epatica. Available at: http://www.pnlg.it/out/002/.
5. Amodio, P., Montagnese, S, Gatta, A., and Morgan, M.Y. (2004b). Characterization of minimal hepatic encephalopathy. Metab. Brain Dis. 19:253-267.
6. Bahn, E., Nolte, W., Kurth, C., Ramadori, G., Ruther, E., and Wiltfang, J. (2002). Quantification of the electroencephalographic theta/alpha ratio for the assessment of portal-systemic encephalopathy following implantation of transjugular intrahepatic portosystemic stent shunt (TIPSS). Metab. Brain Dis. 17:19-28.
7. Bauer, G. (1999). Coma and brain death. In (E. Niedermeyer and F. Lopes Da Silva, eds.), Electroencephalography. Basic Principles, Clinical Applications, and Related Fields, Williams & Wilkins, Baltimore, pp. 459-475.
8. Begleiter, H., Porjesz, B., and Chou, C.L. (1981). Auditory brainstem potentials in chronic alcoholics. Science 211:1064-1066.
9. Bernuau, J., Durand, F., Werner, P., Sauvanet, A., Erlinger, S., and Belghiti, J. (1995). Acute liver failure. Lancet 345:802.
10. Bickford, R.G., and Butt, H.R. (1955). Hepatic coma: The electroencephalographic pattern. J. Clin. Invest. 34:790-799.
11. Bogacz, J., Arcos-Perez, M., and Garcia-Austt, E (1961). Serial electroencephalography in hepatic insufficiency and coma. Atti del VII Congresso Internazionale di Neurologia, 1961. Roma, Edizioni per il Congresso, pp. 185-188.
12. Bonhomme, V., and Hans, P. (2004). Monitoring depth of anaesthesia: Is it worth the effort? Eur. J. Anaesthesiol. 21:423-428.
13. Brenner, R.P. (1985). The electroencephalogram in altered states of consciousness. Neurol. Clin. 3:615-631.
14. Chu, N.S., and Yang, S.S. (1988). Portal-systemic encephalopathy: Alterations in somatosensory and brainstem auditory evoked potentials. J. Neurol. Sci. 84:41-50.
15. Chu, N.S., Yang, S.S., and Liaw, Y.F. (1997). Evoked potentials in liver diseases. J. Gastroenterol. Hepatol. 12:S288-S293.
16. Ciancio, A., Marchet, A., Saracco, G., Carucci, P., Lavezzo, B., Leotta, D., Capellero, B., Nobili, M., Smedile, A., and Rizzetto, M. (2002). Spectral electroencephalogram analysis in hepatic encephalopathy and liver transplantation. Liver Transpl. 8:630-635.
17. Conn, H.O., Leevy, C.M., Vlahcevic, Z.R., Rodgers, J.B., Maddrey, W.C., Seeff, L., and Levy, L.L. (1977). Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. A double blind controlled trial. Gastroenterology 72:573-583.
18. Cordoba, J., Raguer, N., Flavia, M., Vargas, V., Jacas, C., Alonso, J., and Rovira, A. (2003). T2 hyperintensity along the cortico-spinal tract in cirrhosis relates to functional abnormalities. Hepatology 38:1026-1033.
19. Davenport, A., and Bramley, P.N. (1993). Cerebral function analyzing monitor and visual evoked potentials as a noninvasive method of detecting cerebral dysfunction in patients with acute hepatic and renal failure treated with intermittent machine hemofiltration. Ren. Fail. 15:515-522.
20. Davies, M.G., Rowan, M.J., and Feely, J. (1990). Flash visual evoked responses in the early encephalopathy of chronic liver disease. Scand. J. Gastroenterol. 25:1205-1214.
21. De la Torre, G.S., Garcia de Leon, A.M., Bello, M.G., Montero, A.J., Gonzalez, S.L., Torres, S.J., and De la Torre Fernandez, J.M. (1989). Evaluation of hepatic encephalopathy using computerized electroencephalography. Rev. Esp. Enferm. Apar. Dig. 76:138-143.
22. Ellis, A.J., Wendon, J.A., and Williams, R. (2000). Subclinical seizure activity and prophylactic phenytoin infusion in acute liver failure: A controlled clinical trial. Hepatology 32:536-541.
23. Epstein, C.M., Riether, A.M., Henderson, R.M., and Cotsonis, G.A. (1992). EEG in liver transplantation: Visual and computerized analysis. Electroencephalogr. Clin. Neurophysiol. 83:367-371.
24. Fedele, D., Martini, A., Cardone, C., Comacchio, F., Bellavere, F., Molinari, G., Negrin, P., and Crepaldi, G. (1984). Impaired auditory brainstem-evoked responses in insulin-dependent diabetic subjects. Diabetes 33:1085-1089.
25. Grimm, G., Madl, C., Katzenschlager, R., Oder, W., Ferenci, P., and Gangl, A. (1992). Detailed evaluation of evoked potentials in Wilson's disease. Electroencephalogr. Clin. Neurophysiol. 82:119-124.
26. Gallai, V., Alberti, A., Balo, S., Mazzotta, G., Clerici, C., Gentili, G., Firenze, C., and Morelli, A. (1995). Cognitive event-related potential in hepatic encephalopathy. Acta Neurol. Scand. 91:358-361.
27. Grimm, G., Oder, W., Prayer, L., Ferenci, P., and Madl, C. (1990). Evoked potentials in assessment and follow-up of patients with Wilson's disease. Lancet 336:963-964.
28. Groeneweg, M., Quero, J.C., De Bruijn, I., Hartmann, I.J., Essink-bot, M.L., Hop, W.C., and Schalm, S.W. (1998). Subclinical hepatic encephalopathy impairs daily functioning. Hepatology 28:45-49.
29. Guérit, J.M. (1993). Les potentiales évoqués. Masson, Paris.
30. Guérit, J.M. (1998). Neuromonitoring in the operating room: Why, when, and how to monitor? Electroencephalogr. Clin. Neurophysiol. 106:1-21.
31. Hartmann, I.J., Groeneweg, M., Quero, J.C., Beijeman, S.J., de Man, R.A., Hop, W.C., and Schalm,S.W. (2000). The prognostic significance of subclinical hepatic encephalopathy. Am. J. Gastroenterol. 95:2029-2034.
32. Hawkes, C.H., Macpherson, A.I., Pryor, H., and Townsend, H.R. (1970). The value of EEG frequency analysis in hepatic encephalopathy. J. R. Coll. Surg. Edinb. 15:151-157.
33. Jackson, C., and Sherratt, M. (2004). A novel spatio-temporal decomposition of the EEG: Derivation, validation and clinical application. Clin. Neurophysiol. 115:227-237.
34. Jones, D.P., Binnie, C.D., Bown, R.L., Lloyd, D.S., and Watson, B.W. (1976). The contingent negative variation and psychological findings in chronic hepatic encephalopathy. Electroencephalogr. Clin. Neurophysiol. 40:661-665.
35. Kono, I., Ueda, Y., Nakajima, K., Araki, K., Kagawa, K., and Kashima, K. (1994). Subcortical impairment in subclinical hepatic encephalopathy. J. Neurol. Sci. 126:162-167.
36. Kramer, L., Bauer, E., Gendo, A., Funk, G., Madl, C., Pidlich, J., and Gangl, A. (2002). Neurophysiological evidence of cognitive impairment in patients without hepatic encephalopathy after transjugular intrahepatic portosystemic shunts. Am. J. Gastroenterol. 97:162-166.
37. Kuba, M., Kremlácek, J., Hulek, P., Kubová, Z., and Vít, F. (1996). Advanced electrophysiological diagnostics of hepatic and portosystemic encephalopathy. Acta Med. (Hradec Kralove) 39:21-25.
38. Kügler, C.F., Petter, J., Taghavy, A., Lotterer, E., Wensing, G., Hahn, E.G., and Fleig, W.E. (1994). Dynamics of cognitive brain dysfunction in patients with cirrhotic liver disease: An event-related P300 potential perspective. Electroencephalogr. Clin. Neurophysiol. 91:33-41.
39. Kulisevsky, J., Conill, J., Avila, A., Pujol, J., Balanzo, J., and Capdevila, A. (1995). Abnormalities of the Bereitschaftspotential and MRI pallidal signal in non-encephalopathic cirrhotic patients. Electroencephalogr. Clin. Neurophysiol. 94:425-431.
40. Kullmann, F., Hollerbach, S., Holstege, A., and Scholmerich, J. (1995). Subclinical hepatic encephalopathy: The diagnostic value of evoked potentials J. Hepatol. 22:101-110.
41. Kullmann, F., Hollerbach, S., Lock, G., Holstege, A., Dierks, T., and Scholmerich, J. (2001). Brain electrical activity mapping of EEG for the diagnosis of (sub)clinical hepatic encephalopathy in chronic liver disease. Eur. J. Gastroenterol. Hepatol. 13:513-522.
42. Laidlow, J., and Read, A.E. (1961). The electroencephalographic diagnosis of manifest and latent "delirium" with particular reference to that complicating hepatic cirrhosis. J. Neurol. Neurosurg. Psychiatr. 24:58-69.
43. Liu, Q., Duan, Z.P., Ha, D.K., Bengmark, S., Kurtovic, J., and Riordan, S.M. (2004). Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis Hepatology 39:1441-1449.
44. Madl, C., Grimm, G., Ferenci, P., Kramer, L., Yeganehfar, W., Oder, W., Steininger, R., Zauner, C., Ratheiser, K., and Stockenhuber, F. (1994). Serial recording of sensory evoked potentials: A noninvasive prognostic indicator in fulminant liver failure. Hepatology 20:1487-1494.
45. Magliero, A., Bashore, T.R., Coles, M.G., and Donchin, E. (1984). On the dependence of P300 latency on stimulus evaluation processes. Psychophysiology 21:171-186.
46. Mehndiratta, M.M., Sood, G.K., Sarin, S.K., and Gupta, M. (1990). Comparative evaluation of visual, somatosensory, and auditory evoked potentials in the detection of subclinical hepatic encephalopathy in patients with nonalcoholic cirrhosis. Am. J. Gastroenterol. 85:799-803.
47. Montagnese, S., Amodio, P., and Morgan, M.Y. (2004). Methods for diagnosing hepatic encephalopathy in patients with cirrhosis: A multidimensional approach. Metab. Brain Dis. 19:281-312.
48. Niedermeyer, E. (1999a). Metabolic central nervous system disorders. In (E. Niedermeyer and F. Lopes Da Silva, eds.), Electroencephalography. Basic Principles, Clinical Applications, and Related Fields, Williams & Wilkins, Baltimore, pp. 416-431.
49. Niedermeyer, E. (1999b). The normal EEG of the waking adult. In (E. Niedermeyer and F. Lopes Da Silva, eds.), Electroencephalography. Basic Principles, Clinical Applications, and Related Fields, Williams & Wilkins, Baltimore, pp. 149-173.
50. O'Grady, J.G., Schalm, S.W., and Williams, R. (1993). Acute liver failure: Redefining the syndromes. Lancet 342:273-275.
51. Parsons-Smith, B.G., Summerskill, W.H.J., Dawson, A.M., and Sherlock, S. (1957). The electroencephalograph in liver disease. Lancet 2:867-871.
52. Pellegrini, A., Amodio, P., Montagnese, S., Castellaro, A., Del Piccolo, F., Musto, C., and Gatta, A. (2000). Electroencephalographic staging of hepatic encephalopathy by a neural network and an expert system. Clin. Neurophysiol. 111(Suppl. 1):S52.
53. Quero, J.C., Hartmann, I.J., Meulstee, J., Hop, W.C., and Schalm, S.W. (1996). The diagnosis of subclinical hepatic encephalopathy in patients with cirrhosis using neuropsychological tests and automated electroencephalogram analysis. Hepatology 24:556-560.
54. Rampil, I.J. (1998). A primer for EEG signal processing in anesthesia. Anesthesiology 89:980-1002.
55. Rohmer, F., and Kurtz, D. (1961). EEG et ammoniémie dans les troubles nerveux des affections hépatiques. Atti del VII Congresso Internazionale di Neurologia. Roma, Edizioni per il Congresso, pp. 115-163.
56. Romero-Gòmez, M., Boza, F., Garcia-Valdecasas, M.S., Garcia, E., and Aguilar-Reina, J. (2001). Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy. Am. J. Gastroenterol. 96:2718-2723.
57. Sagales, T., Gimeno, V., De la Cazalda, M.D., Casellas, F., Dolors, M.M., and Villar, S.M. (1990). Brain mapping analysis in patients with hepatic encephalopathy. Brain Topogr. 2:221-228.
58. Sandford, N.L., and Saul, R.E. (1988). Assessment of hepatic encephalopathy with visual evoked potentials compared with conventional methods. Hepatology 8:1094-1098.
59. Sawhney, I.M., Verma, P.K., Dhiman, R.K., Chopra, J.S., Sharma, A., Chawla, Y.K., and Dilawari, J.B. (1997). Visual and auditory evoked responses in acute severe hepatitis. J. Gastroenterol. Hepatol. 12:554-559.
60. Saxena, N., Bhatia, M., Joshi, Y.K., Garg, P.K., and Tandon, R.K. (2001). Auditory P300 event-related potentials and number connection test for evaluation of subclinical hepatic encephalopathy in patients with cirrhosis of the liver: A follow-up study. J. Gastroenterol. Hepatol. 16:322-327.
61. Saxena, N., Bhatia, M., Joshi, Y.K., Garg, P.K., Dwivedi, S.N., and Tandon, R.K. (2002). Electrophysiological and neuropsychological tests for the diagnosis of subclinical hepatic encephalopathy and prediction of overt encephalopathy. Liver 22:190-197.
62. Schiff, S., Mapelli, D., Vallesi, A., Del Piccolo, F., Umiltà, C.A., and Amodio, P. (2004). Motor impairment in patients with minimal hepatic encephalopathy evaluated by the lateralized readiness potential. J. Hepatol. 40(Suppl. 1):72.
63. Schiff, S., Vallesi, A., Mapelli, D., Orsato, R., Pellegrini, A., Umiltà, C., Gatta, A., and Amodio, P. (2005). Impairment of response inhibition precede motor alteration in the early stage of liver cirrhosis. A behavioral and electrophysiological study. Metab. Brain Dis. 20(4):381-392.
64. Sutton, S., Braren, M., Zubin, J., and John, E.R. (1965). Evoked-potential correlates of stimulus uncertainty. Science 150:1187-1188.
65. Van der Rijt, C.C., and Schalm, S.W. (1992). Quantitative EEG analysis and evoked potentials to measure (latent) hepatic encephalopathy. J. Hepatol. 14:141-142.
66. van der Rijt, C.C., Schalm, S. W., De Groot, G. H., and De Vlieger, M. (1984). Objective measurement of hepatic encephalopathy by means of automated EEG analysis. Electroencephalogr. Clin. Neurophysiol. 57:423-426.
67. Virtaniemi, J., Kuusisto, J., Karjalainen, L., Karjalainen, S., and Laakso, M. (1995). Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus. Am. J. Otolaryngol. 16:172-176.
68. Wascher, E., Verleger, R., Vieregge, P., Jaskowski, P., Koch, S., and Kompf, D. (1997). Responses to cued signals in Parkinson's disease. Distinguishing between disorders of cognition and of activation. Brain 120(Pt 8):1355-1375.
69. Weissenborn, K., Scholz, M., Hinrichs, H., Wiltfang, J., Schmidt, F.W., and Knkel, H. (1990). Neurophysiological assessment of early hepatic encephalopathy. Electroencephalogr. Clin. Neurophysiol. 75:289-295.
70. Yang, S.S., Chu, N.S., and Liaw, Y.F. (1985). Somatosensory evoked potentials in hepatic encephalopathy. Gastroenterology 89:625-630.
71. Yang, S.S., Chu, N.S., and Liaw, Y.F. (1986). Brainstem auditory evoked potentials in hepatic encephalopathy. Hepatology 6:1352-1355.
72. Yang, S.S., Chu, N.H., and Wu, C.H. (1993a). Subcortical somatosensory evoked potentials in patients with hepatic encephalopathy caused by severe acute hepatitis. J. Gastroenterol. Hepatol. 8:545-549.
73. Yang, S.S., Chu, N.S., and Wu, C.H. (1993b). Disappearance of N20 and P25 components of somatosensory evoked potential: An ominous sign in severe acute hepatitis. J. Formos. Med. Assoc. 92:46-49.
74. Yang, S.S., Wu, C.H., Chiang, T.R., and Chen, D.S. (1998). Somatosensory evoked potentials in subclinical portosystemic encephalopathy: A comparison with psychometric tests. Hepatology 27:357-361.
75. Yen, C.L., and Liaw, Y.F. (1990). Somatosensory evoked potentials and number connection test in the detection of subclinical hepatic encephalopathy. Hepatogastroenterology 37:332-334.
76. Zeneroli, M.L., Pinelli, G., Gollini, G., Penne, A., Messori, E., Zani, G., and Ventura, E. (1984). Visual evoked potential: A diagnostic tool for the assessment of hepatic encephalopathy. Gut 25:291-299.