Reduced sarcoplasmic reticulum Ca2+-ATPase activity and dephosphorylated phospholamban contribute to contractile dysfunction in human hibernating myocardium

Molecular and Cellular Biochemistry

Volumn 282, Issue 1-2, 2006, Pages 53-63

  Nef, Holger M ^a   Möllmann, Helge ^a   Skwara, Woitek ^a   Bölck, Birgit ^b   Schwinger, Robert H G ^b   Hamm, Ch ^a   Kostin, Sawa ^c   Schaper, Jutta ^c   Elsässer, Albrecht ^a  

^a KERCKHOFF HEART CENTER   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Contractile dysfunction; Human hibernating myocardium; Phospholamban; Phosphorylation; SR calcium ATPase activity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); DOBUTAMINE; MESSENGER RNA; PHOSPHOLAMBAN; RYANODINE RECEPTOR; SODIUM CALCIUM EXCHANGE PROTEIN; THALLIUM;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; CORONARY ARTERY DISEASE; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; HEART SCINTISCANNING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MUSCLE CONTRACTION; MYOCARDIAL HIBERNATION; PREOPERATIVE EVALUATION; PROTEIN DEPHOSPHORYLATION; RADIOISOTOPE VENTRICULOGRAPHY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOPLASMIC RETICULUM; TREATMENT INDICATION; WESTERN BLOTTING;

AGED; CALCIUM; CALCIUM-BINDING PROTEINS; CALCIUM-TRANSPORTING ATPASES; HOMEODOMAIN PROTEINS; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIAL STUNNING; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOMERES; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 29644447281     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-1171-7     Document Type: Article

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