Instructive niches: Environmental instructions that confound NG2 proteoglycan expression and the fate-restriction of CNS progenitors

Journal of Anatomy

Volumn 207, Issue 6, 2005, Pages 727-734

  Sellers, Drew L ^a   Horner, Philip J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

CNS progenitors; NG2 proteoglycan expression; Oligodendrocyte populations

Indexed keywords

MEMBRANE PROTEIN; NERVE GLIA 2 PROTEIN; PROTEOCHONDROITIN SULFATE; UNCLASSIFIED DRUG;

ASTROCYTE; BRAIN INJURY; CELL FATE; CELL POPULATION; CELL REGENERATION; CELL TYPE; CENTRAL NERVOUS SYSTEM FUNCTION; ENVIRONMENTAL FACTOR; HUMAN; IN VITRO STUDY; NEURAL STEM CELL; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; REMYELINIZATION; REVIEW; TISSUE LEVEL; VALIDATION PROCESS;

ANIMALS; ANTIGENS; ASTROCYTES; BRAIN; BRAIN INJURIES; CELL COMMUNICATION; CELL PROLIFERATION; HUMANS; MULTIPOTENT STEM CELLS; OLIGODENDROGLIA; PROTEOGLYCANS; REGENERATION; SIGNAL TRANSDUCTION;

EID: 29644437679     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2005.00480.x     Document Type: Review

References (42)

1. Agius E, Soukkarieh C, Danesin C, et al. (2004) Converse control of oligodendrocyte and astrocyte lineage development by Sonic hedgehog in the chick spinal cord. Dev Biol 270, 308-321.
2. Aguirre A, Gallo V (2004) Postnatal neurogenesis and gliogenesis in the olfactory bulb from NG2-expressing progenitors of the subventricular zone. J Neurosci 24, 10530-10541.
3. Beasley L, Stallcup WB (1987) The nerve growth factor-inducible large external (NILE) glycoprotein and neural cell adhesion molecule (N-CAM) have distinct patterns of expression in the developing rat central nervous system. J Neurosci 7, 708-715.
4. Belachew S, Chittajallu R, Aguirre AA, et al. (2003) Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons. J Cell Biol 161, 169-186.
5. Bergles DE, Roberts JD, Somogyi P, Jahr CE (2000) Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405, 187-191.
6. Chang A, Nishiyama A, Peterson J, Prineas J, Trapp BD (2000) NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci 20, 6404-6412.
7. Dawson MR, Polito A, Levine JM, Reynolds R (2003) NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 24, 476-488.
8. Diers-Fenger M, Kirchhoff F, Kettenmann H, Levine JM, Trotter J (2001) AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Glia 34, 213-228.
9. Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A (1999) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-716.
10. Doetsch F (2003) A niche for adult neural stem cells. Curr Opin Genet Dev 13, 543-550.
11. Gensert JM, Goldman JE (1996) In vivo characterization of endogenous proliferating cells in adult rat subcortical white matter. Glia 17, 39-51.
12. Gensert JM, Goldman JE (2001) Heterogeneity of cycling glial progenitors in the adult mammalian cortex and white matter. J Neurobiol 48, 75-86.
13. Gomes WA, Mehler MF, Kessler JA (2003) Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment. Dev Biol 255, 164-177.
14. Hampton DW, Rhodes KE, Zhao C, Franklin RJ, Fawcett JW (2004) The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain. Neuroscience 127, 813-820.
15. Horner PJ, Gage FH (2000) Regenerating the damaged central nervous system. Nature 407, 963-970.
16. Horner PJ, Thallmair M, Gage FH (2002) Defining the NG2-expressing cell of the adult CNS. J Neurocytol 31, 469-480.
17. Horner PJ, Palmer TD (2003) New roles for astrocytes: the nightlife of an 'astrocyte'. La vida loca!. Trends Neurosci 26, 597-603.
18. Jeffery ND, Crang AJ, O'Leary T, Hodge M, SJ Blakemore WF (1999) Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in the rat spinal cord. Eur J Neurosci 11, 1508-1514.
19. Jones LL, Yamaguchi Y, Stallcup WB, Tuszynski MH (2002) NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci 22, 2792-2803.
20. Keirstead HS, Levine JM, Blakemore WF (1998) Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia 22, 161-170.
21. Kruger GM, Morrison SJ (2002) Brain repair by endogenous progenitors. Cell 110, 399-402.
22. Levine JM, Card JP (1987) Light and electron microscopic localization of a cell surface antigen (NG2) in the rat cerebellum: association with smooth protoplasmic astrocytes. J Neurosci 7, 2711-2720.
23. Levine JM, Stallcup WB (1987) Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen. J Neurosci 7, 2721-2731.
24. Levine JM, Stincone F, Lee YS (1993) Development and differentiation of glial precursor cells in the rat cerebellum. Glia 7, 307-321.
25. Levine JM, Reynolds R (1999) Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Exp Neurol 160, 333-347.
26. Levison SW, Young GM, Goldman JE (1999) Cycling cells in the adult rat neocortex preferentially generate oligodendroglia. J Neurosci Res 57, 435-446.
27. Lim DA, Tramontin AD, Trevejo JM, Herrera DG, Garcia-Verdugo JM, Alvarez-Buylla A (2000) Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron 28, 713-726.
28. Matthias K, Kirchhoff F, Seifert G, et al. (2003) Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus. J Neurosci 23, 1750-1758.
29. McTigue DM, Wei P, Stokes BT (2001) Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. J Neurosci 21, 3392-3400.
30. Nishiyama A, Lin XH, Giese N, Heldin CH, Stallcup WB (1996) Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain. J Neurosci Res 43, 299-314.
31. + glial cells are distinct from resting and activated microglia. J Neurosci Res 48, 299-312.
32. Nunes MC, Roy NS, Keyoung HM, et al. (2003) Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 9, 439-447.
33. Palmer TD, Markakis EA, Willhoite AR, Safar F, Gage FH (1999) Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 19, 8487-8497.
34. Palmer TD, Willhoite AR, Gage FH (2000) Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 425, 479-494.
35. van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH (2002) Functional neurogenesis in the adult hippocampus. Nature 415, 1030-1034.
36. Raff MC, Miller RH, Noble M (1983) A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature 303, 390-396.
37. Schools GP, Zhou M, Kimelberg HK (2003) Electrophysiologically 'complex' glial cells freshly isolated from the hippocampus are immunopositive for the chondroitin sulfate proteoglycan NG2. J Neurosci Res 73, 765-777.
38. Seri B, Garcia-Verdugo JM, McEwen BS, Alvarez-Buylla A (2001) Astrocytes give rise to new neurons in the adult mammalian hippocampus. J Neurosci 21, 7153-7160.
39. Shihabuddin LS, Horner PJ, Ray J, Gage FH (2000) Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci 20, 8727-8735.
40. Ventura R, Harris KM (1999) Three-dimensional relationships between hippocampal synapses and astrocytes. J Neurosci 19, 6897-6906.
41. Wu Q, Miller RH, Ransohoff RM, Robinson S, Bu J, Nishiyama A (2000) Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20, 2609-2617.
42. Zerlin M, Milosevic A, Goldman JE (2004) Glial progenitors of the neonatal subventricular zone differentiate asynchronously, leading to spatial dispersion of glial clones and to the persistence of immature glia in the adult mammalian CNS. Dev Biol 270, 200-213