Chromosomes lacking telomeres are present in the progeny of human lymphocytes exposed to heavy ions

Radiation Research

Volumn 165, Issue 1, 2006, Pages 51-58

  Durante, M ^a   George, K ^b   Cucinotta, F A ^c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b WYLE LABORATORIES   (United States)

^c NASA JOHNSON SPACE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAVY ION; IRON;

ARTICLE; CELL CYCLE; CHROMOSOME ABERRATION; CHROMOSOME BANDING PATTERN; CHROMOSOME BREAKAGE; CHROMOSOME DELETION; CROSS SPECIES MULTICOLOR BANDING; DOSE RESPONSE; GAMMA RADIATION; HIGH CHARGE AND ENERGY PARTICLE; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; LYMPHOCYTE; MALE; MOLECULAR PROBE; NORMAL HUMAN; NUCLEON; PRIORITY JOURNAL; PROGENY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; TELOMERE; TERMINAL DELETION;

CELL DIVISION; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOMES; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; HEAVY IONS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; RADIATION DOSAGE; TELOMERE;

EID: 29644437327     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3477.1     Document Type: Article

References (40)

1. M. N. Cornforth and J. S. Bedford, Ionizing radiation damage and its early development in chromosomes. Adv. Radiat. Biol. 17, 423-497 (1993).
2. G. Obe, P. Pfeiffer, J. R. K. Savage, C. Johannes, W. Goedecke, P. Jeppesen, A. T. Natarajan, W. Martinez-Lopez, G. A. Folle and M. E. Drets, Chromosomal aberrations: Formation, identification and distribution. Mutat. Res. 504, 17-36 (2002).
3. H. Wu, K. George and T. C. Yang, Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes. Int. J. Radiat. Biol. 73, 521-527 (1998).
4. J. Fomina, F. Darroudi, J. J. Boeri and A. T. Natarajan, Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe. Int. J. Radiat. Biol. 76, 807-813 (2000).
5. K. George, M. Durante, V. Willingham, H. Wu, T. C. Yang and F. A. Cucinotta, Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase human lymphocytes. Radiat. Res. 160, 425-435 (2003).
6. M. Durante, Y. Furusawa, K. George, G. Gialanella, O. Greco, G. Grossi, N. Matsufuji, M. Pugliese and T. C. Yang, Rejoining and misrejoining of radiation-induced chromatin breaks. IV. Charged particles. Radiat. Res. 149, 446-454 (1998).
7. H. Wu, M. Durante, Y. Furusawa, K. George, T. Kawata and F. A. Cucinotta, Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions. Radiat. Res. 160, 418-424 (2003).
8. R. S. Maser and R. A. DePinho, Connecting chromosomes, crisis, and cancer. Science 297, 565-569 (2002).
9. D. M. Feldser, J. A. Hackett and C. W. Greider, Telomere dysfunction and the initiation of genome instability. Nat. Rev. Cancer 3, 623-627 (2003).
10. S. E. Artandi, S. Chang, S. L. Lee, S. Alson, G. J. Gottlieb, L. Chin and R. A. DePinho, Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406, 641-645 (2000).
11. D. Gisselsson, T. Jonsson, A. Petersén, B. Strömbeck, P. Dal Cin, M. Höglund, F. Mitelman, F. Mertens and N. Mandahl, Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc. Natl. Acad. Sci. USA 98, 12683-12688 (2001).
12. R. M. Anderson, D. L. Stevens and D. T. Goodhead, M-FISH analysis shows that complex chromosome aberrations induced by alpha-particle tracks are cumulative products of localized rearrangements. Proc. Natl. Acad. Sci. USA 99, 12167-12172 (2002).
13. M. P. Hande, T. V. Azizova, C. R. Geard, L. E. Burak, C. R. Mitchell, V. F. Khokhryakov, E. K. Vasilenko and D. J. Brenner, Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am. J. Hum. Genet. 72, 1162-1170 (2003).
14. S. Müller, P. C. O'Brien, M. A. Ferguson-Smith and J. Wienberg, Cross-species colour segmenting: A novel tool in human karyotype analysis. Cytometry 33, 445-452 (1998).
15. C. Zeitlin, L. Heilbronn and J. Miller, Detailed characterization of the 1087 MeV/nucleon iron-56 beam used for radiobiology at the alternating gradient synchrotron. Radiat. Res. 149, 560-569 (1998).
16. M. R. Teixeira, Combined classical and molecular cytogenetic analysis of cancer. Eur. J. Cancer 38, 1580-1584 (2002).
17. T. Liehr, H. Starke, A. Weise, H. Lehrer and U. Claussen, Multicolor FISH probe sets and their applications. Histol. Histopathol. 19, 229-237 (2004).
18. E. Schröck, S. du Manoir, T. Veldman, B. Schoell, J. Wienberg. M. A. Ferguson-Smith, Y. King, D. H. Ledbetter, I. Bar-Am and T. Ried, Multicolor spectral karyotyping of human chromosomes. Science 273, 494-497 (1996).
19. M. N. Cornforth, Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting. Radiat. Res. 155, 643-659 (2001).
20. I. Chudoba, G. Hickmann, T. Friedrich, A. Jauch, P. Kozlowski and G. Senger, mBAND: a high resolution multicolor banding technique for the detection of complex intrachromosomal aberrations. Cytogenet. Genome Res. 104, 390-393 (2004).
21. M. Horstmann and G. Obe, CABAND: Classification of aberrations in multicolor banded chromosomes. Cytogenet. Genome Res. 103, 24-27 (2003).
22. J. R. K. Savage, Reflections and meditations upon complex chromosomal exchanges. Mutat. Res. 512, 93-109 (2002).
23. K. George, H. Wu, V. Willingham, Y. Furusawa, T. Kawata and F. A. Cucinotta, High- and low-LET induced chromosome damage in human lymphocytes: A time-course of aberrations in metaphase and interphase. Int. J. Radiat. Biol. 77, 175-183 (2001).
24. R. M. Anderson, S. J. Marsden, S. J. Paice, A. E. Bristow, M. A. Kadhim, C. S. Griffin and D. T. Goodhead, Transmissible and non-transmissible complex chromosome aberrations characterized by three-color and mFISH define a biomarker of exposure to high-LET alpha particles. Radiat. Res. 159, 40-48 (2003).
25. M. Durante, K. George, H. Wu and F. A. Cucinotta, Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat. Res. 158, 581-590 (2002).
26. C. Johannes, M. Horstmann, M. Durante, I. Chudoba and G. Obe, Chromosome intrachanges and interchanges detected by multicolor banding in lymphocytes: Searching for clastogen signatures in the human genome. Radiat. Res. 161, 540-548 (2004).
27. M. N. Cornforth and J. S. Bedford, On the nature of a defect in cells from individuals with ataxia-telangiectasia. Science 227, 1589-1591 (1985).
28. Y. Stewenius, L. Gorunova, T. Jonson, N. Larsson, M. Hoglund, N. Mandahl, F. Mertens, F. Mitelman and D. Gisselsson, Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. Proc. Natl. Acad. Sci. USA 102, 5441-5446 (2005).
29. NCRP, Radiation Protection Guidance for Activities in Low-Earth Orbit. Report No. 132, National Council on Radiation Protection and Measurements, Bethesda, MD, 2000.
30. M. Durante, S. Bonassi, K. George and F. A. Cucinotta, Risk estimation based on chromosomal aberrations induced by radiation. Radiat. Res. 156, 662-667 (2001).
31. E. L. Alpen, P. Powers-Risius, S. B. Curtis and R. DeGuzman, Tumorigenic potential of high-Z, high-LET charged-particle radiations. Radiat. Res. 136, 382-391 (1993).
32. E. A. Blakely and A. Kronenberg, Heavy-ion radiobiology: New approaches to delineate mechanisms underlying enhanced biological effectiveness. Radiat. Res. 150 (Suppl.), S126-S145 (1998).
33. L. Sabatier, B. Dutrillaux and M. B. Martin, Chromosomal instability. Nature 357, 548 (1992).
34. M. B. Martin, L. Sabatier, M. Ricoul, A. Pinton and B. Dutrillaux, Specific chromosome instability induced by heavy ions: A step towards transformation of human fibroblasts? Mutat. Res. 285, 229-237 (1993).
35. L. Sabatier, J. Lebeau and B. Dutrillaux, Chromosomal instability and alterations of telomeric repeats in irradiated human fibroblasts. Int. J. Radiat. Biol. 66, 611-613 (1994).
36. L. Sabatier, M. Ricoul, G. Pettier and J. P. Murnane, The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line. Mol. Cancer Res. 3, 139-150 (2005).
37. J. W. Shay and W. E. Wright, Aging. When do telomeres matter? Science 291, 839-840 (2001).
38. J. Campisi, Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522 (2005).
39. F. A. Cucinotta, F. K. Manuel, J. Jones, G. Iszard, J. Murrey, B. Djojonegro and M. Wear, Space radiation and cataracts in astronauts. Radiat. Res. 156, 460-466 (2001).
40. 56Fe- particle radiation. Radiat. Res. 158, 725-734 (2002).