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Volumn 16, Issue 3, 2006, Pages 587-591

The electronic structure of human erythropoietin as an aid in the design of oxidation-resistant therapeutic proteins

Author keywords

Anemia; Computational chemistry; Erythropoietin; Protein based therapeutics

Indexed keywords

ERYTHROPOIETIN; MUTANT PROTEIN;

EID: 29544452805     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.10.041     Document Type: Article
Times cited : (4)

References (31)
  • 22
    • 29544435741 scopus 로고    scopus 로고
    • note
    • Note that the H-L energy gap computed in the gas phase corresponds to only 0.59 eV (PM5). It appears that COSMO significantly increases the energy of LUMO thus widening the H-L gap with respect to that computed in the gas phase.
  • 23
    • 0010844436 scopus 로고
    • The dipole moment is that of an ion and is related to the center of mass, see: A.D. Buckingham Chem. Soc. (Great Britain) Quart. Rev. 13 1959 183 We chose to draw the dipole vector by placing the middle point of the arrow on the center of mass of the protein, see:
    • (1959) Chem. Soc. (Great Britain) Quart. Rev. , vol.13 , pp. 183
    • Buckingham, A.D.1
  • 25
    • 0021978310 scopus 로고
    • The dipole moment associated to the peptide bond corresponds to about 3.46 debye, see: W.G.J. Hol Prog. Biophys. Mol. Biol. 45 1985 149
    • (1985) Prog. Biophys. Mol. Biol. , vol.45 , pp. 149
    • Hol, W.G.J.1
  • 30
    • 0033789318 scopus 로고    scopus 로고
    • For computational studies addressing the effect of sugar chains on the conformation of proteins and peptides see, for example: J. Zuegg, and J.E. Gready Glycobiology 10 2000 959
    • (2000) Glycobiology , vol.10 , pp. 959
    • Zuegg, J.1    Gready, J.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.