Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression

Journal of Applied Physiology

Volumn 99, Issue 4, 2005, Pages 1359-1363

  Cluberton, Laura J ^a   McGee, Sean L ^a,b   Murphy, Robyn M ^a,c   Hargreaves, Mark ^a,b  

^a DEAKIN UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c LA TROBE UNIVERSITY   (Australia)

Author keywords

Skeletal muscle; Transcription

Indexed keywords

GENE PRODUCT; GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCOGEN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PLACEBO; PYRUVATE DEHYDROGENASE KINASE 4; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 3;

ADAPTATION; ADULT; ARTICLE; CARBOHYDRATE INTAKE; CONTROLLED STUDY; CYCLING; EXERCISE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLYCOGEN MUSCLE LEVEL; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; METABOLIC REGULATION; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE;

ADULT; BEVERAGES; BICYCLING; CARRIER PROTEINS; DIETARY CARBOHYDRATES; GENE EXPRESSION; GLUCOSE TRANSPORTER TYPE 4; HUMANS; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; PROTEIN KINASES; QUADRICEPS MUSCLE; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 29544448956     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00197.2005     Document Type: Article

References (33)

1. Andersen PH, Lund S, Vestergaard H, Junker S, Kahn BB, and Pedersen O. Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion. J Clin Endocrinol Metab 77: 27-32, 1993.
2. Assimacopoulos-Jeannet F, Cusin I, Greco-Perotto RM, Terrettaz J, Rohner-Jeanrenaud F, Zarjevski N, and Jeanrenaud B. Glucose transporters: structure, function, and regulation. Biochimie 73: 67-70, 1991.
3. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, Kelly DP, and Holloszy JO. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J 16: 1879-1886, 2002.
4. Bowker-Kinley MM, Davis WI, Wu P, Harris RA, and Popov KM. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 329: 191-196, 1998.
5. Cooke DW and Lane MD. The transcription factor nuclear factor I mediates repression of the GLUT4 promoter by insulin. J Biol Chem 274: 12917-12924, 1999.
6. Cortright RN, Zheng D, Jones JP, Fluckey JD, DiCarlo SE, Grujic D, Lowell BB, and Dohm GL. Regulation of skeletal muscle UCP-2 and UCP3 gene expression by exercise and denervation. Am J Physiol Endocrinol Metab 276: E217-E221, 1999.
7. Evans W, Phinney S, and Young V. Suction applied to a muscle biopsy maximizes sample size. Med Sci Sports Exerc 14: 101-102, 1986.
8. Furuyama T, Kitayama K, Yamashita H, and Mori N. Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Biochem J 375: 365-371, 2003.
9. Handschin C, Rhee J, Lin J, Tarr PT, and Spiegelman BM. An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1 alpha expression in muscle. Proc Natl Acad Sci USA 100: 7111-7116, 2003.
10. Hesselink MK, Mensink M, and Schrauwen P. Human uncoupling protein-3 and obesity: an update. Obes Res 11: 1429-1443, 2003.
11. Huang B, Wu P, Bowker-Kinley MM, and Harris RA. Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticords and insulin, Diabetes 51: 276-283, 2002.
12. Kraniou Y, Cameron-Smith D, Misso M, Collier G, and Hargreaves M. Effects of exercise on GLUT4 and glycogenin gene expression in human skeletal muscle. J Appl Physiol 88: 794-796, 2000.
13. Kuo C, Hunt D, Ding Z, and Ivy J. Effect of carbohydrate supplementation on postexercise GLUT4 protein expression in skeletal muscle. J Appl Physiol 87: 2290-2295, 1999.
14. Kuo CH, Hwang H, Lee MC, Castle AL, and Ivy JL. Role of insulin on exercise-induced GLUT4 protein expression and glycogen supercompensation in rat skeletal muscle. J Appl Physiol 96: 621-627, 2004.
15. Lee FN, Zhang L, Zheng D, Choi WS, and Youn JH. Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Am J Physiol Endocrinol Metab 287: E69-E74, 2004.
16. Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, and Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418: 797-801, 2002.
17. Neufer PD, Carey JO, and Dohm GL. Transcriptional regulation of the gene for glucose transporter GLUT4 in skeletal muscle. Effects of diabetes and fasting. J Biol Chem 268: 13824-13829, 1993.
18. Neufer PD and Dohm GL. Exercise induces a transient increase in transcription of the GLUT4 gene in skeletal muscle. Am J Physiol Cell Physiol 265: C1597-C1603, 1993.
19. Ojuka EO. Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. Proc Nutr Soc 63: 275-278, 2004.
20. 2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle. FASEB J 17: 675-681, 2003.
21. Passonneau JV and Lauderdale VR: A comparison of three methods of glycogen measurement in tissues. Anal Biochem 60: 405-412, 1974.
22. Peters SJ, Harris RA, Heigenhauser GJ, and Spriet LL. Muscle fiber type comparison of PDH kinase activity and isoform expression in fed and fasted rats. Am J Physiol Regul Integr Comp Physiol 280: R661-R668, 2001.
23. Pilegaard H, Keller C, Steensberg A, Helge JW, Pedersen BK, Saltin B, and Neufer PD. Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes. J Physiol 541: 261-271, 2002.
24. Pilegaard H, Ordway GA, Saltin B, and Neufer PD. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab 279: E806-E814, 2000.
25. Postic C, Leturque A, Rencurel F, Printz RL, Forest C, Granner DK, and Girard J. The effects of hyperinsulinemia and hyperglycemia on GLUT4 and hexokinase II mRNA and protein in rat skeletal muscle and adipose tissue. Diabetes 42: 922-929, 1993.
26. Rena G, Guo S, Cichy SC, Unterman TG, and Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274: 17179-17183, 1999.
27. Schrauwen P, Hesselink MK, Vaartjes I, Kornips E, Saris WH, Giacobino JP, and Russell A. Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect. Am J Physiol Endocrinol Metab 282: E11-E17, 2002.
28. Sivitz WI, DeSautel SL, Kayano T, Bell GI, and Pessin JE. Regulation of glucose transporter messenger RNA in insulin-deficient states. Nature 340: 72-74, 1989.
29. Son C, Hosoda K, Matsuda J, Fujijura J, Yonemitsu S, Iwakura H, Masuzaki H, Ogawa Y, Hayashi T, Itoh H, Nishimura H, Inoue G, Yoshimasa Y, Yamori Y, and Nakao K. Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists fo PPARs in L6 myotubes. Endocrinology 142: 4189-4194, 2001.
30. Spriet LL, Tunstall RJ, Watt MJ, Mehan KA, Hargreaves M, and Cameron-Smith D. Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting. J Appl Physiol 96: 2082-2087, 2004.
31. Suwa M. Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3 and PGC-1 in rat muscles. J Appl Physiol 95: 960-968, 2003.
32. Tunstall RJ, Mehan KA, Hargreaves M, Spriet LL, and Cameron-Smith D. Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle. Biochem Biophys Res Commun 294: 301-308, 2002.
33. Weigle DS, Selfridge LE, Schwartz MW, Seeley RJ, Cummings DE, Havel PJ, Kuijper JL, and BeltrandelRio H. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting. Diabetes 47: 298-302, 1998.