-
1
-
-
0347885319
-
Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000
-
SHIBUYA K, MATHERS CD, BOSCHI-PINTO C, LOPEZ AD, MURRAY CJ: Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000. BMC Cancer (2002) 2(1):37.
-
(2002)
BMC Cancer
, vol.2
, Issue.1
, pp. 37
-
-
Shibuya, K.1
Mathers, C.D.2
Boschi-Pinto, C.3
Lopez, A.D.4
Murray, C.J.5
-
2
-
-
16244379562
-
The evolving role of pemetrexed (Alimta) in lung cancer
-
SOCINSKI MA, STINCHCOMBE TE, HAYES DN: The evolving role of pemetrexed (Alimta) in lung cancer. Semin. Oncol. (2005) 32(2 Suppl. 2):S16-S22.
-
(2005)
Semin. Oncol.
, vol.32
, Issue.2 SUPPL. 2
-
-
Socinski, M.A.1
Stinchcombe, T.E.2
Hayes, D.N.3
-
3
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced small-cell lung cancer
-
SCHILLER JH, HARRINGTON D, BELANI CP et al: Comparison of four chemotherapy regimens for advanced small-cell lung cancer. N. Engl. J. Med. (2002) 346(2):92-98.
-
(2002)
N. Engl. J. Med.
, vol.346
, Issue.2
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
-
4
-
-
0035397994
-
Randomized Phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: A Southwest Oncology Group trial
-
KELLY K, CROWLEY J, BUNN PA Jr et al.: Randomized Phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: a Southwest Oncology Group trial. J. Clin. Oncol. (2001) 19(13):3210-3218.
-
(2001)
J. Clin. Oncol.
, vol.19
, Issue.13
, pp. 3210-3218
-
-
Kelly, K.1
Crowley, J.2
Bunn Jr., P.A.3
-
5
-
-
0036843105
-
Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer
-
SCAGLIOTTI G, DE MARINIS F, RINALDI M et al.: Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer. J. Clin. Oncol. (2002) 20(21):4285-4291.
-
(2002)
J. Clin. Oncol.
, vol.20
, Issue.21
, pp. 4285-4291
-
-
Scagliotti, G.1
De Marinis, F.2
Rinaldi, M.3
-
6
-
-
0042413836
-
Randomized, multinational, Phase III study of docetaxel plus combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: The TAX 326 study group
-
FOSSELLA F, PEREIRA JR, VON PAWEL J et al.: Randomized, multinational, Phase III study of docetaxel plus combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: the TAX 326 study group. J. Clin. Oncol. (2003) 21(16):3016-3024.
-
(2003)
J. Clin. Oncol.
, vol.21
, Issue.16
, pp. 3016-3024
-
-
Fossella, F.1
Pereira, J.R.2
Von Pawel, J.3
-
7
-
-
1342268525
-
American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003
-
PFISTER DG, JOHNSON DH, AZZOLI CG et al.: American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J. Clin. Oncol. (2004) 22(2):330-353.
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.2
, pp. 330-353
-
-
Pfister, D.G.1
Johnson, D.H.2
Azzoli, C.G.3
-
8
-
-
2442661845
-
Randomized Phase III trial of pemetrexed versus docetaxel in patients with non-small cell lung cancer previously treated with chemotherapy
-
HANNAN N, SHEPHERD FA, FOSSELLA FV et al.: Randomized Phase III trial of pemetrexed versus docetaxel in patients with non-small cell lung cancer previously treated with chemotherapy. J. Clin. Oncol. (2004) 22(9):1589-1597.
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.9
, pp. 1589-1597
-
-
Hannan, N.1
Shepherd, F.A.2
Fossella, F.V.3
-
9
-
-
21044449609
-
Esmo Guidelines Task Force: ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of non-small-cell lung cancer (NSCLC)
-
FELIP E, STAHEL RA, PAVLIDIS N; ESMO GUIDELINES TASK FORCE: ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of non-small-cell lung cancer (NSCLC). Ann. Oncol. (2005) 16(Suppl. 1)i28-i29.
-
(2005)
Ann. Oncol.
, vol.16
, Issue.SUPPL. 1
-
-
Felip, E.1
Stahel, R.A.2
Pavlidis, N.3
-
10
-
-
0012381722
-
Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial)
-
FUKUOKA M, YANO S, GIACCONE G et al.: Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial). J. Clin. Oncol. (2003) 21(12):2237-2246.
-
(2003)
J. Clin. Oncol.
, vol.21
, Issue.12
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
11
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
KRIS M NATALE RB, HERBST R et al.: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA (2003) 290(16):2149-2158.
-
(2003)
JAMA
, vol.290
, Issue.16
, pp. 2149-2158
-
-
Kris, M.1
Natale, R.B.2
Herbst, R.3
-
12
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A Phase III trial-INTACT 2
-
HERBST RS, GIACCONE G, SCHILLER JH et al.: Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a Phase III trial-INTACT 2. J. Clin. Oncol. (2004) 22(5):785-794.
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.5
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
-
13
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A Phase III trial - INTACT 1
-
GIACCONE G, HERBST RS, MANEGOLD C et al.: Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a Phase III trial - INTACT 1. J. Clin. Oncol. (2004) 22(5):777-784.
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.5
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
-
14
-
-
23844438017
-
Results from a Phase II, open-label, randomized study (SIGN) comparing gefitinib with docetaxel as second-line therapy in patients with advanced (stage IIIb or IV) non-small-cell lung cancer
-
(Abstract)
-
CUFER T, VRDOLJAK E: Results from a Phase II, open-label, randomized study (SIGN) comparing gefitinib with docetaxel as second-line therapy in patients with advanced (stage IIIb or IV) non-small-cell lung cancer. J. Clin. Oncol. (2005) 23(16S):7035 (Abstract).
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.16 S
, pp. 7035
-
-
Cufer, T.1
Vrdoljak, E.2
-
15
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
SHEPHERD FA, RODRIGUES PEREIRA J, CIULEANU T et al.: Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. (2005) 353(2):123-132.
-
(2005)
N. Engl. J. Med.
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
16
-
-
4444238981
-
Results of a Phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small-cell lung cancer (NSCLC)
-
(Abstract)
-
GATZEMEIER U, PLUZANSKA A, SZCZESNA A et al.: Results of a Phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small-cell lung cancer (NSCLC). J. Clin. Oncol. (2004) 22(14S):7010 (Abstract).
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.14 S
, pp. 7010
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
-
17
-
-
24944440830
-
TRIBUTE-A Phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
-
HERBST RS, PRAGER D, HERMANN R et al.: TRIBUTE-A Phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J. Clin. Oncol. (2005) 23(25):5892-5899.
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.25
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
-
18
-
-
17844390172
-
Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions
-
PAO W, MILLER VA: Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions. J. Clin. Oncol. (2005) 23(11):2556-2568.
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.11
, pp. 2556-2568
-
-
Pao, W.1
Miller, V.A.2
-
19
-
-
26844567033
-
A Phase II study of erlotinib as first-line treatment of advanced non-small-cell lung cancer
-
(Abstract)
-
GIACCONE G, LECHEVALIER N, THATCHER N et al.: A Phase II study of erlotinib as first-line treatment of advanced non-small-cell lung cancer. J. Clin. Oncol. (2005) 23(16S):7073 (Abstract).
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.16 S
, pp. 7073
-
-
Giaccone, G.1
Lechevalier, N.2
Thatcher, N.3
-
20
-
-
26444607230
-
Correlation of molecular markets including mutations with clinical outcomes in advanced non-small-cell lung cancer (NSCLC) patients treated with gefitinib, chemotherapy or gefitinib and chemotherapy in IDEAL and INTACT clinical trials
-
(Abstract)
-
LYNCH TJ, BELL D, HABER D et al.: Correlation of molecular markets including mutations with clinical outcomes in advanced non-small-cell lung cancer (NSCLC) patients treated with gefitinib, chemotherapy or gefitinib and chemotherapy in IDEAL and INTACT clinical trials. J. Clin. Oncol. (2005) 23(16S):7006 (Abstract).
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.16 S
, pp. 7006
-
-
Lynch, T.J.1
Bell, D.2
Haber, D.3
-
21
-
-
4944238261
-
Interstitial lung disease associated with drug therapy
-
CAMUS P, KUDOH S, EBINA M: Interstitial lung disease associated with drug therapy. Br. J. Cancer (2004) 91(Suppl. 2):S18-S23.
-
(2004)
Br. J. Cancer
, vol.91
, Issue.SUPPL. 2
-
-
Camus, P.1
Kudoh, S.2
Ebina, M.3
-
22
-
-
24644445676
-
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients
-
CAPPUZZO F, VARELLA-GARCIA M, SHIGEMATSU H et al.: Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. J. Clin. Oncol. (2005) 23(22):5007-5018.
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.22
, pp. 5007-5018
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Shigematsu, H.3
-
23
-
-
22044453790
-
Erlotinib in lung cancer-molecular and clinical predictors of outcome
-
TSAO MS, SAKURADA A, CUTZ JC et al.: Erlotinib in lung cancer-molecular and clinical predictors of outcome. N. Engl. J. Med. (2005) 353(2):133-144.
-
(2005)
N. Engl. J. Med.
, vol.353
, Issue.2
, pp. 133-144
-
-
Tsao, M.S.1
Sakurada, A.2
Cutz, J.C.3
-
24
-
-
3042663513
-
Cetuximab in advanced non-small cell lung cancer
-
GOVINDAN R: Cetuximab in advanced non-small cell lung cancer. Clin. Cancer Res. (2004) 10(12 Pt 2):4241s-4244s.
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.12 PART 2
-
-
Govindan, R.1
-
25
-
-
3042524076
-
Novel agents in the treatment of lung cancer: Conference summary statement
-
LYNCH TJ, ADJEI AA, BUNN PA Jr et al.: Novel agents in the treatment of lung cancer: conference summary statement. Clin. Cancer Res. (2004) 10(12 Pt 2):4199s-4204s.
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.12 PART 2
-
-
Lynch, T.J.1
Adjei, A.A.2
Bunn Jr., P.A.3
-
26
-
-
0031852056
-
Multiple folate enzyme inhibition: Mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)
-
SHIH C, HABECK LL, MENDELSOHN LG, CHEN VJ, SCHULTZ RM: Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). Adv. Enzyme Regul. (1998) 38:135-152.
-
(1998)
Adv. Enzyme Regul.
, vol.38
, pp. 135-152
-
-
Shih, C.1
Habeck, L.L.2
Mendelsohn, L.G.3
Chen, V.J.4
Schultz, R.M.5
-
27
-
-
0033817515
-
The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate
-
ZHAO R, BABANI S, GAO F, LIU L, GOLDMAN ID: The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate. Clin. Cancer Res. (2000) 6(9):3687-3695.
-
(2000)
Clin. Cancer Res.
, vol.6
, Issue.9
, pp. 3687-3695
-
-
Zhao, R.1
Babani, S.2
Gao, F.3
Liu, L.4
Goldman, I.D.5
-
28
-
-
0032950347
-
Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis
-
MENDELSOHN LG, SHIH C, CHEN VJ, HABECK LL, GATES SB, SHACKELFORD KA: Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis. Semin. Oncol. (1999) 26(2 Suppl. 6):42-47.
-
(1999)
Semin. Oncol.
, vol.26
, Issue.2 SUPPL. 6
, pp. 42-47
-
-
Mendelsohn, L.G.1
Shih, C.2
Chen, V.J.3
Habeck, L.L.4
Gates, S.B.5
Shackelford, K.A.6
-
29
-
-
0026494947
-
A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H -pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
-
TAYLOR EC, KUHNT D, SHIH C et al.: A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H -pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. J. Med. Chem. (1992) 35(23):4450-4454.
-
(1992)
J. Med. Chem.
, vol.35
, Issue.23
, pp. 4450-4454
-
-
Taylor, E.C.1
Kuhnt, D.2
Shih, C.3
-
30
-
-
0032898580
-
Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514
-
SCHULTZ RM, PATEL VF, WORZALLA JF, SHIH C: Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514. Anti-Cancer Res. (1999) 19(1A):437-443.
-
(1999)
Anti-Cancer Res.
, vol.19
, Issue.1 A
, pp. 437-443
-
-
Schultz, R.M.1
Patel, V.F.2
Worzalla, J.F.3
Shih, C.4
-
31
-
-
0030891198
-
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
-
SHIH C, CHEN VJ, GOSSETT LS et al.: LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. (1997) 57(6):1116-1123.
-
(1997)
Cancer Res.
, vol.57
, Issue.6
, pp. 1116-1123
-
-
Shih, C.1
Chen, V.J.2
Gossett, L.S.3
-
32
-
-
0031858217
-
Preclinical cellular pharmacology of LY231514 (MTA): A comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRFCEM cells
-
CHEN VJ, BEWLEY JR, ANDIS SL et al.: Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRFCEM cells. Br. J. Cancer (1998) 78(Suppl. 3):27-34.
-
(1998)
Br. J. Cancer
, vol.78
, Issue.SUPPL. 3
, pp. 27-34
-
-
Chen, V.J.1
Bewley, J.R.2
Andis, S.L.3
-
33
-
-
0037842139
-
Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma
-
SCAGLIOTTI GV, SHIN DM, KINDLER HL et al.: Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma. J. Clin. Oncol. (2003) 21(8):1556-1561.
-
(2003)
J. Clin. Oncol.
, vol.21
, Issue.8
, pp. 1556-1561
-
-
Scagliotti, G.V.1
Shin, D.M.2
Kindler, H.L.3
-
34
-
-
0032908148
-
Multitargeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: A Phase II study
-
National Cancer Institute of Canada Clinical Trials Group
-
RUSTHOVEN JJ, EISENHAUER E, BUTTS C et al.: Multitargeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: a Phase II study. National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. (1999) 17(4):1194-1199.
-
(1999)
J. Clin. Oncol.
, vol.17
, Issue.4
, pp. 1194-1199
-
-
Rusthoven, J.J.1
Eisenhauer, E.2
Butts, C.3
-
35
-
-
0034655141
-
Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: Results from a Phase II study
-
JOHN W, PICUS J, BLANKE CD et al.: Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: results from a Phase II study. Cancer (2000) 88(8):1807-1813.
-
(2000)
Cancer
, vol.88
, Issue.8
, pp. 1807-1813
-
-
John, W.1
Picus, J.2
Blanke, C.D.3
-
36
-
-
0033981350
-
Phase II study of the multitargeted antifolate LY231514 (ALIMTA, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer
-
MILLER KD, PICUS J, BLANKE C et al.: Phase II study of the multitargeted antifolate LY231514 (ALIMTA, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer. Ann. Oncol. (2000) 11(1):101-103.
-
(2000)
Ann. Oncol.
, vol.11
, Issue.1
, pp. 101-103
-
-
Miller, K.D.1
Picus, J.2
Blanke, C.3
-
37
-
-
0032965322
-
Overview of Phase II trials of MTA in solid tumors
-
O'DWYER PJ, NELSON K, THORNTON DE: Overview of Phase II trials of MTA in solid tumors. Semin. Oncol. (1999) 26(2 Suppl. 6):99-104.
-
(1999)
Semin. Oncol.
, vol.26
, Issue.2 SUPPL. 6
, pp. 99-104
-
-
O'Dwyer, P.J.1
Nelson, K.2
Thornton, D.E.3
-
38
-
-
0035446433
-
Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck
-
PIVOT X, RAYMOND E, LAGUERRE B et al.: Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck. Br. J. Cancer (2001) 85(5):649-655.
-
(2001)
Br. J. Cancer
, vol.85
, Issue.5
, pp. 649-655
-
-
Pivot, X.1
Raymond, E.2
Laguerre, B.3
-
39
-
-
0034861227
-
Pemetrexed disodium: A novel antifolate clinically active against multiple solid tumors
-
HANAUSKE AR, CHEN V, PAOLETTI P, NIYIKIZA C: Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist (2001) 6(4):363-373.
-
(2001)
Oncologist
, vol.6
, Issue.4
, pp. 363-373
-
-
Hanauske, A.R.1
Chen, V.2
Paoletti, P.3
Niyikiza, C.4
-
40
-
-
0035012196
-
Activity of pemetrexed (ALIMTA, multitargeted antifolate, LY231514) in metastatic breast cancer patients previously treated with an anthracycline and a taxane: An interim analysis
-
SPIELMANN M, MARTIN M, NAMER M, DUBOIS A, UNGER C, DODWELL DJ: Activity of pemetrexed (ALIMTA, multitargeted antifolate, LY231514) in metastatic breast cancer patients previously treated with an anthracycline and a taxane: an interim analysis. Clin. Breast Cancer (2001) 2(1):47-51.
-
(2001)
Clin. Breast Cancer
, vol.2
, Issue.1
, pp. 47-51
-
-
Spielmann, M.1
Martin, M.2
Namer, M.3
Dubois, A.4
Unger, C.5
Dodwell, D.J.6
-
41
-
-
0041629528
-
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
-
VOGELZANG NJ, RUSTHOVEN JJ, SYMANOWSKI J et al.: Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J. Clin. Oncol. (2003) 21(14):2636-2644.
-
(2003)
J. Clin. Oncol.
, vol.21
, Issue.14
, pp. 2636-2644
-
-
Vogelzang, N.J.1
Rusthoven, J.J.2
Symanowski, J.3
-
42
-
-
0036562507
-
Homocysteine and methylmalonic acid: Markets to predict and avoid toxicity from pemetrexed therapy
-
NIYIKIZA C, BAKER SD, SEITZ DE et al.: Homocysteine and methylmalonic acid: markets to predict and avoid toxicity from pemetrexed therapy. Mol. Cancer Ther. (2002) 1(7):545-552.
-
(2002)
Mol. Cancer Ther.
, vol.1
, Issue.7
, pp. 545-552
-
-
Niyikiza, C.1
Baker, S.D.2
Seitz, D.E.3
-
43
-
-
0032964124
-
Overview of Phase I trials of multitargeted antifolate (MTA, LY231514)
-
RINALDI DA: Overview of Phase I trials of multitargeted antifolate (MTA, LY231514). Semin. Oncol. (1999) 26(2 Suppl. 6):82-88.
-
(1999)
Semin. Oncol.
, vol.26
, Issue.2 SUPPL. 6
, pp. 82-88
-
-
Rinaldi, D.A.1
-
44
-
-
0000700872
-
Comparative human pharmacokinetics of MTA in three Phase I studies
-
(Abstract)
-
SHARMA A, JOHNSON RD, WOODWORTH JM: Comparative human pharmacokinetics of MTA in three Phase I studies. Proc. Am. Soc. Clin. Oncol. (1998) 17:900 (Abstract).
-
(1998)
Proc. Am. Soc. Clin. Oncol.
, vol.17
, pp. 900
-
-
Sharma, A.1
Johnson, R.D.2
Woodworth, J.M.3
-
45
-
-
23744482948
-
A Phase I/II study of pemetrexed and vinorelbine in patients with non-small cell lung cancer
-
CLARKE SJ, BOYER MJ, MILLWARD M et al.: A Phase I/II study of pemetrexed and vinorelbine in patients with non-small cell lung cancer. Lung Cancer. (2005) 49(3):401-412.
-
(2005)
Lung Cancer
, vol.49
, Issue.3
, pp. 401-412
-
-
Clarke, S.J.1
Boyer, M.J.2
Millward, M.3
-
46
-
-
0032859301
-
A Phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation
-
RINALDI DA, KUHN JG, BURRIS HA et al.: A Phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation. Cancer Chemother. Pharmacol. (1999) 44(5):372-380.
-
(1999)
Cancer Chemother. Pharmacol.
, vol.44
, Issue.5
, pp. 372-380
-
-
Rinaldi, D.A.1
Kuhn, J.G.2
Burris, H.A.3
-
47
-
-
33644839682
-
A Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function
-
(In press)
-
MITA AC, SWEENEY CJ, BAKER SD et al.: A Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function. J. Clin. Oncol. (2005) (In press).
-
(2005)
J. Clin. Oncol.
-
-
Mita, A.C.1
Sweeney, C.J.2
Baker, S.D.3
-
48
-
-
17644404490
-
Phase I study of pemetrexed (LY231514) with vitamin supplementation in patients with locally advanced or metastatic cancer
-
(Abstract)
-
HAMMOND LA, FORERO L, BEERAM M et al.: Phase I study of pemetrexed (LY231514) with vitamin supplementation in patients with locally advanced or metastatic cancer. Proc. Am. Soc. Clin. Oncol. (2003) 22:532 (Abstract).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
, pp. 532
-
-
Hammond, L.A.1
Forero, L.2
Beeram, M.3
-
49
-
-
17644365918
-
A Phase I study of pemetrexed supplemented with folic acid (FA) and vitamin B12 (VB12) in Japanese patients with solid tumors
-
(Abstract 486)
-
NAKAGAWA K, KUDOH S, MATSUI K et al.: A Phase I study of pemetrexed supplemented with folic acid (FA) and vitamin B12 (VB12) in Japanese patients with solid tumors. Eur. J. Cancer Suppl. (2004) 2(8):148 (Abstract 486).
-
(2004)
Eur. J. Cancer Suppl.
, vol.2
, Issue.8
, pp. 148
-
-
Nakagawa, K.1
Kudoh, S.2
Matsui, K.3
-
50
-
-
0035985288
-
Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-naïve patients with advanced non-small-cell lung cancer
-
CLARKE SJ, ABRATT R, GOEDHALS L. BOYER MJ, MILLWARD MJ, ACKLAND SP: Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-naïve patients with advanced non-small-cell lung cancer. Ann. Oncol. (2002) 13(5):737-741.
-
(2002)
Ann. Oncol.
, vol.13
, Issue.5
, pp. 737-741
-
-
Clarke, S.J.1
Abratt, R.2
Goedhals, L.3
Boyer, M.J.4
Millward, M.J.5
Ackland, S.P.6
-
51
-
-
0037352426
-
Alimta (pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: A Phase II study
-
SMIT EF, MATTSON K, VON PAWEL J, MANEGOLD, CLARKE S, POSTMUS PE: ALIMTA (pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: a Phase II study. Ann. Oncol. (2003) 14(3):455-460.
-
(2003)
Ann. Oncol.
, vol.14
, Issue.3
, pp. 455-460
-
-
Smit, E.F.1
Mattson, K.2
Von Pawel, J.3
Manegold Clarke, S.4
Postmus, P.E.5
-
52
-
-
0242520400
-
A Phase III study of pemetrexed versus docetaxel in patients with advanced non-small-cell lung (NSCLC) who were previously treated with chemotherapy
-
(PL-5)
-
SHEPHERD FA, PEREIRA JR, VON PAWEL J et al.: A Phase III study of pemetrexed versus docetaxel in patients with advanced non-small-cell lung (NSCLC) who were previously treated with chemotherapy. Lung Cancer (2003) 41(Suppl. 2):S4 (PL-5).
-
(2003)
Lung Cancer
, vol.41
, Issue.SUPPL. 2
-
-
Shepherd, F.A.1
Pereira, J.R.2
Von Pawel, J.3
-
53
-
-
1042309425
-
Multiple regression analysis of prognostic variables for survival from the Phase III study of pemetrexed versus docetaxel in non-small-cell lung cancer (NSCLC)
-
(O-5)
-
HANNA N, PAUL S, DEMARINIS F et al.: Multiple regression analysis of prognostic variables for survival from the Phase III study of pemetrexed versus docetaxel in non-small-cell lung cancer (NSCLC). Lung Cancer (2003) 41(Suppl. 2):S5 (O-5).
-
(2003)
Lung Cancer
, vol.41
, Issue.SUPPL. 2
-
-
Hanna, N.1
Paul, S.2
Demarinis, F.3
-
54
-
-
29444449427
-
An exploratory analysis of a Phase III study in patients with advanced non-small cell lung cancer (NSCLC): The impact of first-line gemcitabine and platinum therapy on the outcome of second-line therapy with pemetrexed or docetaxel
-
(PD-068)
-
BUNN PA Jr, ROSELL R, FOSSELLA F et al.: An exploratory analysis of a Phase III study in patients with advanced non-small cell lung cancer (NSCLC): the impact of first-line gemcitabine and platinum therapy on the outcome of second-line therapy with pemetrexed or docetaxel. Lung Cancer (2005) 49(2):S86 (PD-068).
-
(2005)
Lung Cancer
, vol.49
, Issue.2
-
-
Bunn Jr., P.A.1
Rosell, R.2
Fossella, F.3
-
55
-
-
32044465836
-
Risk-benefit of pemetrexed compared with docetaxel in patients with advanced non-small cell lung cancer (NSCLC) previously treated with chemotherapy: An analysis of toxicity-free survival
-
(Abstract 709P)
-
PUJOL J-L, PAUL S, GATZEMEIER U, KAYITALIRE L BERRY D: Risk-benefit of pemetrexed compared with docetaxel in patients with advanced non-small cell lung cancer (NSCLC) previously treated with chemotherapy: an analysis of toxicity-free survival. Ann. Oncol. (2004) 15(Suppl. 3):iii87 (Abstract 709P).
-
(2004)
Ann. Oncol.
, vol.15
, Issue.SUPPL. 3
-
-
Pujol, J.-L.1
Paul, S.2
Gatzemeier, U.3
Kayitalire, L.4
Berry, D.5
-
56
-
-
27144456556
-
Post study docetaxel in non-small cell lung cancer (NSCLC) patients after discontinuation from a randomized Phase III trial of pemetrexed versus docetaxel: An exploratory analysis
-
(Abstract)
-
PUJOL J-L, SHAHARYAR S, KORTSIK C et al.: Post study docetaxel in non-small cell lung cancer (NSCLC) patients after discontinuation from a randomized Phase III trial of pemetrexed versus docetaxel: an exploratory analysis. J. Clin. Oncol. (2004) 22(14S):7135 (Abstract).
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.14 S
, pp. 7135
-
-
Pujol, J.-L.1
Shaharyar, S.2
Kortsik, C.3
-
57
-
-
0034029995
-
Front-line treatment of advanced non-small-cell lung cancer with MTA (LY231514, pemetrexed disodium, ALIMTA) and cisplatin: A multicenter Phase II trial
-
MANEGOLD C, GATZEMEIER U, VON PAWEL J et al.: Front-line treatment of advanced non-small-cell lung cancer with MTA (LY231514, pemetrexed disodium, ALIMTA) and cisplatin: a multicenter Phase II trial. Ann. Oncol. (2000) 11(4):435-440.
-
(2000)
Ann. Oncol.
, vol.11
, Issue.4
, pp. 435-440
-
-
Manegold, C.1
Gatzemeier, U.2
Von Pawel, J.3
-
58
-
-
0035423962
-
Phase II study of pemetrexed disodium, a multitargeted antifolate, and cisplatin as first-line therapy in patients with advanced nonsmall cell lung carcinoma
-
A study of the National Cancer Institute of Canada Clinical Trials Group
-
SHEPHERD FA, DANCEY J, ARNOLD A et al.: Phase II study of pemetrexed disodium, a multitargeted antifolate, and cisplatin as first-line therapy in patients with advanced nonsmall cell lung carcinoma. A study of the National Cancer Institute of Canada Clinical Trials Group. Cancer (2001) 92(3):595-600.
-
(2001)
Cancer
, vol.92
, Issue.3
, pp. 595-600
-
-
Shepherd, F.A.1
Dancey, J.2
Arnold, A.3
-
59
-
-
19944426696
-
Pemetrexed combined with oxaliplatin or carboplatin as first-line treatment in advanced non-small-cell lung cancer: A multicenter, randomized Phase II trial
-
SCAGLIOTTI G, KORTSIK C, DARK GG et al.: Pemetrexed combined with oxaliplatin or carboplatin as first-line treatment in advanced non-small-cell lung cancer: a multicenter, randomized Phase II trial. Clin. Cancer Res. (2005) 11(2 Pt 1):690-696.
-
(2005)
Clin. Cancer Res.
, vol.11
, Issue.2 PART 1
, pp. 690-696
-
-
Scagliotti, G.1
Kortsik, C.2
Dark, G.G.3
-
60
-
-
20244380204
-
A Phase II trial of pemetrexed (P) plus carboplatin (C) in patients (pts) with advanced non-small cell lung cancer (NSCLC)
-
(Abstract)
-
KOSHY S, HERBST RS, OBASAJU CK et al.: A Phase II trial of pemetrexed (P) plus carboplatin (C) in patients (pts) with advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol. (2004) 22(14S):7074 (Abstract).
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.14 S
, pp. 7074
-
-
Koshy, S.1
Herbst, R.S.2
Obasaju, C.K.3
-
61
-
-
23744482948
-
A Phase I/II of pemetrexed and vinorelbine in patients with non-small cell lung cancer
-
CLARKE SJ, BOYER MJ, MILLWARD M et al., A Phase I/II of pemetrexed and vinorelbine in patients with non-small cell lung cancer. Lung Cancer (2005) 49(3):401-412.
-
(2005)
Lung Cancer
, vol.49
, Issue.3
, pp. 401-412
-
-
Clarke, S.J.1
Boyer, M.J.2
Millward, M.3
-
62
-
-
33244473038
-
A Phase I dose-escalating study of combination pemetrexed-based chemotherapy and concomitant radiotherapy for locally advanced or metastatic non-small cell lung or esophageal cancer
-
(Abstract)
-
SEIWERT TY, CONNELL PP, MAUER AM et al.: A Phase I dose-escalating study of combination pemetrexed-based chemotherapy and concomitant radiotherapy for locally advanced or metastatic non-small cell lung or esophageal cancer. J. Clin. Oncol. (2005) 23(16S):7062 (Abstract).
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.16 S
, pp. 7062
-
-
Seiwert, T.Y.1
Connell, P.P.2
Mauer, A.M.3
-
63
-
-
0032937239
-
Antifolates: The next millennium
-
ALLEGRA CJ: Antifolates: the next millennium. Semin. Oncol. (1999) 26(2 Suppl. 6):1-2.
-
(1999)
Semin. Oncol.
, vol.26
, Issue.2 SUPPL. 6
, pp. 1-2
-
-
Allegra, C.J.1
-
64
-
-
22144471081
-
Randomized Phase II/III trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC 704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Group (ECOG) trial-E4599
-
(Abstract)
-
SANDLER AB, GRAY R, BRAHMER J et al.: Randomized Phase II/III trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC 704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): an Eastern Cooperative Group (ECOG) trial-E4599. Proc. Am. Soc. Clin. Oncol. (2005) 24:4 (Abstract).
-
(2005)
Proc. Am. Soc. Clin. Oncol.
, vol.24
, pp. 4
-
-
Sandler, A.B.1
Gray, R.2
Brahmer, J.3
|