Therapy of focal viral encephalitis in children with aciclovir and recombinant β-interferon - Results of a placebo-controlled multicenter study

European Journal of Medical Research

Volumn 10, Issue 12, 2005, Pages 527-531

  Wintergerst, Uwe ^a   Kugler, K ^a   Harms, F ^b   Belohradsky, B H ^a   Pfluger, T ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Aciclovir; Encephalitis; Herpes simplex virus; Interferons

Indexed keywords

ACICLOVIR; PLACEBO; RECOMBINANT BETA INTERFERON;

ANTIBODY PRODUCTION; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CHILD; CHILDHOOD DISEASE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEVER; FOLLOW UP; GERMANY; HERPES SIMPLEX VIRUS; HUMAN; HYPOKALEMIA; HYPOTENSION; LIVER TOXICITY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NEPHROTOXICITY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGANIC PSYCHOSYNDROME; PROGNOSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SLOVENIA; SUPRAVENTRICULAR PREMATURE BEAT; THROMBOCYTOPENIA; TREATMENT OUTCOME; VIRUS ENCEPHALITIS; VIRUS ISOLATION; VOMITING;

ACYCLOVIR; ADOLESCENT; ANTIVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ENCEPHALITIS, VIRAL; FEMALE; FOCAL INFECTION; HERPES SIMPLEX; HUMANS; INFANT; INTERFERON-BETA; MALE; NERVOUS SYSTEM; RECOMBINANT PROTEINS; RECOVERY OF FUNCTION; TREATMENT OUTCOME;

EID: 29444453505     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Cinque P., Cleator G.M., Weber T., Monteyne P., van Loon A.M.: (1996) The role of laboratory investigations in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. J Neurol Neurosurg Psychiatry 61:339-45
2. Hässler A, Weinmann H.-M, Emmrich P, Pfünder A. Herpes-Enzephalitis: Therapieprobleme. Beitrag zur 42.Jahrestagung der Süddt. Gesellschaft für Kinderheilkunde und Jugendmedizin, Passau, 21.-23.5.1993
3. Heidemann E (1982) Fibroblasten-Interferon zur Behandlung des Herpes zoster. Dtsch Med Wochenschr 107:695-97
4. Janz C, Wigand R (1982) Combined interaction of antiherpes substances and interferon-beta on the multiplication of herpes simplex virus. Arch Virol 73:135-43
5. Prange HW, Weber TH (1986) Zur Behandlung der schweren Virusenzephalitis mit Interferon und Virustatika. Med Klin 81:657-62
6. Prange HW, Weber T, Wismann H (1984) Treatment of viral encephalitis with systemic and intra-thecal beta-interferon. Antivir Res 3:92 D20.
7. Pickering LK, Baker CJ, Overturf GD et al. (2003) Red-book of the Committee of Infectious Diseses, American Academy of Pediatrics 141, Northwest Point Blvd, Elk Grove Village, IL 60009-0927
8. Rahal JJ, Anderson J, Rosenberg C, Reagan T, Thompson LL (2004) Effect of interferon-alpha2b therapy on St. Louis viral meningoencephalitis: clinical and laboratory results of a pilot study. J Infect Dis 190:1084-7
9. Schmidt A, Bunjes D, Friedrich J, Koenig W, Eggeling T, Hombach V (1990) Neurological outcome after a severe herpes simplex encephalitis treated with acyclovir and β-interferon. Time course of intracranial pressure. Klin. Wochenschr. 68:286-9
10. Schroth G, Gawehn J, Thron A, Vallbracht A, Voigt K (1987) Early diagnosis of herpes-simplex encephalitis by MRI. Neurology 37:179-183.
11. Sköldenberg B, Forsgren M, Alestig K, Bergström T, Burman L, Dahlqvist E, Forkman A, Fryden A, Lovgren K, Norlin K, Norrby R, Olding-Stenkvist E, Stiernstedt G, Uhnll I, De Vahl K (1984) Acyclovir versus vidarabine in herpes simplex encephalitis. Randomised multicentre study in consecutive Swedish patients. Lancet i. 707-711.
12. Solomon T, Dung NM, Wills B, Kneen R, Gainsborough M, Diet TV, Thuy TT, Loan HT, Khanh VC, Vaughn DW, White NJ, Farrar JJ (2003) Interferon alfa-2a in Japanese encephalitis: a randomised double-blind placebo-controlled trial. Lancet. 361:821-6
13. Whitley RJ, Alford CA, Hirsch MS, Schooley RT, Luby JP, Aoki FY, Hanley D, Nahmias AJ, Seng-Jaw S (1986) Vidarabine versus Aciclovir therapy in herpes simplex encephalitis. N. Engl. J. Med. 314:114-9
14. Whitley RJ, Alford CA, Hirsch MS, Schooley RT, Luby JP, Aoki FY, Hanley D, Nahmias AJ, Seng-Jaw S (1987) Factors indicative of outcome in a comparative trial of aciclovir and vidarabine for biopsy-prooven herpes simplex encephalitis. Infection 15:3-8.
15. Whitley RJ (1988) Herpes simplex virus infections of the central nervous system. Am J Med 85 (Suppl. 2a):61-67.
16. Whitley RJ. (1990). Viral encephalitis. N Engl J Med 323:242-250
17. Wintergerst U, Belohradsky BH (1992) Acyclovir monotherapy versus acyclovir plus beta-interferon in focal viral encephalitis in children. Infection 20:207-12
18. Wintergerst U, Gangemi JD, Whitley RJ, Chatterjee S, and Kern ER (1999) Effect of recombinant human interferon α B/D (rHu-IFN-α B/D) in combination with acyclovir in experimental HSV-1 encephalitis. Antivir Res 44:75-8
19. Worthmann W. (1985) Generalisierte Herpes-simplex-Virusinfektion. Kombinierte Behandlung mit Aciclovir und Humaninterferon-β. Münch Med Wschr 127:262-3