Interferon alfa-2a in Japanese encephalitis: A randomised double-blind placebo-controlled trial

Lancet

Volumn 361, Issue 9360, 2003, Pages 821-826

  Solomon, Tom ^a,e   Dung, Nguyen Minh ^d   Wills, Bridget ^b,e   Kneen, Rachel ^c,e   Gainsborough, Mary ^e   Diet, Tran Vinh ^d   Thuy, Tran Thi Nhu ^d   Loan, Ha Thi ^d   Khanh, Vo Cong ^d   Vaughn, David W ^f   White, Nicholas J ^b,g   Farrar, Jeremy J ^b,e  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ALDER HEY CHILDREN'S NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^g MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; PLACEBO;

ADOLESCENT; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EPIDEMIC ENCEPHALITIS; FEVER; HOSPITAL DISCHARGE; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MORTALITY; NEUTROPENIA; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SERODIAGNOSIS; SIDE EFFECT; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; VIET NAM;

EID: 0037426083     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)12709-2     Document Type: Article

References (31)

1. Solomon T., Cardosa M.J. Emerging arboviral encephalitis. BMJ. 321:2000;1484-1485.
2. Centers for Disease Control and Prevention. West Nile virus update: current case count http://www.cdc.gov/od/oc/media/wncount.htm . (accessed Oct, 4, 2002.
3. Tsai T.F. New initiatives for the control of Japanese encephalitis by vaccination: minutes of a WHO/CVI meeting, Bangkok, Thailand, 13-15 October 1998. Vaccine. 18:(suppl 2):2000;1-25.
4. Solomon T., Dung N.M., Kneen R., Gainsborough M., Vaughn D.W., Khanh V.T. Japanese encephalitis. J Neurol Neurosurg Psychiatry. 68:2000;405-415.
5. Solomon T., Dung N.M., Kneen R., et al. Seizures and raised intracranial pressure in Vietnamese patients with Japanese encephalitis. Brain. 125:2002;1084-1093.
6. Solomon T., Kneen R., Dung N.M., et al. Poliomyelitis-like illness due to Japanese encephalitis virus. Lancet. 351:1998;1094-1097.
7. Solomon T., Mallewa M.J. Dengue and other emerging flaviviruses. J Infect. 42:2001;104-115.
8. Hoke C.H., Vaughn D.W., Nisalak A., et al. Effect of high dose dexamethasone on the outcome of acute encephalitis due to Japanese encephalitis virus. J Infect Dis. 165:1992;631-637.
9. Burke D.S., Morrill J.C. Levels of interferon in the plasma and cerebrospinal fluid of patients with acute Japanese encephalitis. J Infect Dis. 155:1987;797-799.
10. Houglum J.E. Interferon: mechanism of action and clinical value. Clinical Pharmacology. 2:1983;20-28.
11. Harinasuta C., Wasi C., Vithanomsat S. The effect of interferon on Japanese encephalitis virus in vitro. Southeast Asian J Trop Med Public Health. 15:1984;564-568.
12. Anderson J.F., Rahal J.J. Efficacy of interferon alpha-2b and ribavirin against West Nile virus in vitro. Emerg Infect Dis. 8:2002;107-108.
13. Harinasuta C., Nimmanitya S., Titsyakorn U. The effect of interferon alpha on two cases of Japanese encephalitis in Thailand. SE Asian J Trop Med Public Health. 16:1985;332-336.
14. Harinasuta C., Nimmannitya S., Titsyakorn U., Titsa U., Hiranyachote U. A clinical trial of interferon-alpha on Japanese encephalitis in Thailand. Southeast Asian J Trop Med Public Health. 20:1989;656-657. (abstr).
15. Solomon T., Dung N.M., Vaughn D.W., et al. Neurological manifestations of dengue infection. Lancet. 355:2000;1053-1059.
16. Teasdale G., Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 2:1974;81-84.
17. Molyneux M.E., Taylor T.E., Wirima J.J., Borgstein A. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. QJM. 71:1989;441-459.
18. Guidelines for the management of convulsions with fever. BMJ. 303:1991;634-636.
19. Verity C.M., Butler N.R., Golding J. Febrile convulsions in a national cohort followed up from birth I: prevalence and recurrence in the first five years of life. Brit Med J. 290:1985;1307-1310.
20. Phu N.H., Day N., Diep P.T., Ferguson D., White N.J. Intraleucocytic malaria pigment and prognosis in severe malaria. Trans R Soc Trop Med Hyg. 89:1995;200-204.
21. Solomon T, Thao LTT, Dung NM, et al. Clinical features of Japanese encephalitis: prognostic and pathophysiological significance in 50 patients. 7th International Congress for Infectious Diseases 1996, Hong Kong: 132.
22. Frankenberg W.K., Dodds J.B. The Denver developmental screening test manual. 1968;University of Colorado Press, Denver.
23. Solomon T., Thao L.T.T., Dung N.M., et al. Rapid diagnosis of Japanese encephalitis by using an IgM dot enzyme immunoassay. J Clin Microbiol. 36:1998;2030-2034.
24. Innis B.L., Nisalak A., Nimmannitya S., et al. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg. 40:1989;418-427.
25. World Health Organisation. Cancer treatment: WHO recommendations for grading of acute and subacute toxicity. Geneva: World Health Organisation, 1981.
26. Harrington D.G., Hilmas D.E., Elwell M.R., Whitmire R.E., Stephen E.L. Intranasal infection of monkeys with Japanese encephalitis virus: clinical response and treatment with a nuclease-resistant derivative of poly (I) poly (C). Am J Trop Med Hyg. 26:1977;1191-1198.
27. Vithanomsat S., Wasi C., Harinasuta C., Thongcharoen P. The effect of interferon alpha on flaviviruses in vitro: a preliminary study. Southeast Asian J Trop Med Public Health. 15:1984;27-31.
28. Smith R.A., Norris F., Palmer D., Bernhardt L., Wills R.J. Distribution of alpha interferon in serum and cerebrospinal fluid after systemic administration. Clin Pharmacol Ther. 37:1985;85-88.
29. Solomon T., Vaughn D.W. Clinical features and pathophysiology of Japanese encephalitis and West Nile virus infections. Mackenzie J.S., Barrett A.D., Deubel V. Current Topics in Microbiology and Immunology: Japanese encephalitis and West Nile virus infections. 2002;171-194 Springer-Verlag, Berlin.
30. Warrell M.J., White N.J., Looareesuwan S., et al. Failure of interferon alpha and tribavirin in rabies encephalitis. BMJ. 299:1989;830-833.
31. Solomon T., Hart C.A., Vinjamuri S., Beeching N.J., Malucci C., Humphrey P. Treatment of subacute sclerosing panencephalitis with interferon alpha, ribavirin, and inosiplex. J Child Neurol. 17:2002;703-705.