Polymer microparticles fabricated by soft lithography

Chemistry of Materials

Volumn 17, Issue 25, 2005, Pages 6227-6229

  Guan, Jingjiao ^a   Chakrapani, Aravind ^a   Hansford, Derek J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OPTICAL PROFILERS; PARTICLE FABRICATION; POLYMER MICROPARTICLES; POLYPROPYL METHACRYLATE (PPMA); SOFT LITHOGRAPHY;

CHARACTERIZATION; FABRICATION; LITHOGRAPHY; THIN FILMS;

POLYMERS;

EID: 29444449928     PISSN: 08974756     EISSN: None     Source Type: Journal    
DOI: 10.1021/cm049392p     Document Type: Article

References (16)

1. Braeckmans, K.; De Smedt, S. C.; Roelant, C.; Leblans, M.; Pauwels, R.; Demeester, J. Nat. Rev. Drug Discovery 2002, 1, 447.
2. Han, M.; Gao, X.; Su, J. Z.; Nie, S. Nat. Biotechnol. 2001, 19, 631.
3. Andrianov, A. K.; Payne, L. G. Adv. Drug Delivery Rev. 1998, 34, 155.
4. Zhu, G.; Mallery, S. R.; Schwendeman, S. P. Nat. Biotechnol. 2000, 18, 52.
5. Kumar, M. N. V. R. J. Pharm. Pharm. Sci. 2000, 3, 234.
6. Karumanchi, R. S. M. S.; Doddamane, S. N.; Sampangi, C.; Todd, P. W. Trends Biotechnol. 2002, 20, 72.
7. Fossheim, S. L.; Kellar, K. E.; Månsson, S.; Colet, J.; Rongved, P.; Fahlvik, A. K.; Klaveness, J. J. Magn. Reson. Imag. 1999, 9, 295.
8. Correas, J.; Bridal, L.; Lesavre, A.; Méjean, A.; Claudon, M.; Hélénon, O. Eur. Radiol. 2001, 11, 1316.
9. Jain, R. A. Biomaterials 2000, 21, 2475.
10. Ahmed, A.; Bonner, C.; Desai, T. A. Biomed. Microdevices 2001, 3, 89.
11. Tao, S. L.; Desai, T. A. Adv. Drug Delivery Rev. 2003, 55, 315.
12. Xia, Y.; Whitesides, G. M. Annu. Rev. Mater. Sci. 1998, 28, 153.
13. Wang, M.; Braun, H.; Kratzmüller, T.; Meyer, E. Adv. Mater. 2001, 13, 1312.
14. Twenty-four microparticles in two different areas were measured using software installed with the optical profiler. A straight line was drawn across the center of a set of particles each time to generate a contour plot as shown in Figure 2d. The width of the particles was measured from edge to edge of the microparticles on the plot. To measure the thickness, a cursor was placed at the center of the measured microparticle, and another was placed besides the measured microparticle and at the center of the area between two adjacent microparticles. To obtain the average of thickness of measured microparticle, the cursor on microparticle was set to be 20 μm wide because the microparticles had steep sides and a relatively flat top area, which is approximate 20 μm wide. The cursor placed on substrate area was set to be 10 μm wide to minimize errors caused by noise. The height is averaged across the width of the region denoted by the cursors and the difference between two heights was the thickness of the microparticle. For each set of data, mean and standard deviation were calculated.
15. Twenty-three microparticles in two different areas were measured using the same method as above. The microparticles had a central flat area of approximately 20 μm wide surrounded by thick edges. The thickness of the flat area was measured and analyzed by placing a cursor of 20 μm wide at the center of the particle and another of 5 μm wide besides the measured microparticle in the center of the area between two adjacent microparticles.
16. Guan, J.; Lee, L. J.; Hansford, D. Submitted for publication.