Investigation of lanthanide-based starch particles as a model system for liver contrast agents

Journal of Magnetic Resonance Imaging

Volumn 9, Issue 2, 1999, Pages 295-303

  Fossheim, Sigrid L ^a   Kellar, Kenneth E ^b   Månsson, Sven ^c   Colet, Jean Marie ^d   Rongved, Pål ^e   Fahlvik, Anne Kjersti ^e   Klaveness, Jo ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b Nycomed Amersham Imaging   (United States)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF MONS   (Belgium)

^e NYCOMED IMAGING AS   (Norway)

Author keywords

Dysprosium; Gadolinium; Liver contrast efficacy; Starch particles; Susceptibility effects

Indexed keywords

DYSPROSIUM DIETHYLENETRIAMINE PENTAACETIC ACID STARCH; GADOLINIUM PENTETATE DERIVATIVE; GADOLINIUM PENTETATE STARCH; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; STARCH MICROSPHERE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DISTRIBUTION; HEPATOGRAPHY; IMAGE QUALITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALS; CONTRAST MEDIA; DYSPROSIUM; GADOLINIUM DTPA; LIVER; MAGNETIC RESONANCE IMAGING; MALE; METALS, RARE EARTH; ORGANOMETALLIC COMPOUNDS; PARTICLE SIZE; PENTETIC ACID; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ATOMIC; TISSUE DISTRIBUTION;

EID: 0032968346     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2586(199902)9:2<295::AID-JMRI22>3.0.CO;2-L     Document Type: Article

References (34)

1. Schwendener RA. Liposomes as carriers for paramagnetic gadolinium chelates as organ specific contrast agents for magnetic resonance imaging (MRI). J Liposome Res 1994;4:837-855.
2. Burnett KR, Wolf GL, Schumacher HR Jr, Goldstein EJ. Gadolinium oxide: a prototype agent for contrast enhanced imaging of liver and spleen with magnetic resonance. Magn Reson Imaging 1985;3: 65-71.
3. Braddock-Wilking J, Nosco DL, Hynes MR, Galen KP, Dorshow RB, Adams MD. Manganese hydroxylapatite as a potential MR contrast agent for liver imaging. Invest Radiol 1994;29:S251-S254.
4. Wisner ER, Merisko-Liversidge E, Kellar K, et al. Preclinical evaluation of manganese carbonate particles for magnetic resonance imaging of the liver. Acad Radiol 1995;2:140-147.
5. Saeed M, Wendland MF, Higgins CB. Contrast media for MR imaging of the heart. J Magn Reson Imaging 1994;4:269-279.
6. Moseley ME, Vexler Z, Asgari HS, et al. Comparison of Gd- and Dy-chelates for T2* contrast-enhanced imaging. Magn Reson Med 1991;22:259-264.
7. Dennie J, Sorensen AG, Weisskoff RM, et al. Hemodynamic imaging with Dy-DTPA-BMA in humans: direct comparison with Gd chelates. In: Proceedings of the 4th Annual Meeting of the International Society for Magnetic Resonance in Medicine. New York: International Society for Magnetic Resonance in Medicine; 1996. p 1716.
8. Gillis P, Koenig SH. Transverse relaxation of solvent protons induced by magnetized spheres: application to ferritin, erythrocytes and magnetite. Magn Reson Med 1987;5:323-345.
9. Rongved P, Lindberg B, Klaveness J. Cross-linked, degradable starch microspheres as carriers of paramagnetic contrast agents for magnetic resonance imaging: synthesis, degradation, and relaxation properties. Carbohydr Res 1991;214:325-330.
10. Rongved P, Klaveness J, Strande P. Starch microspheres as carriers for x-ray imaging contrast agents: synthesis and stability of new amino-acid linker derivatives. Carbohydr Res 1997;297:325-331.
11. Fossheim S, Johansson C, Fahlvik AK, Grace D, Klaveness J. Lanthanide-based susceptibility contrast agents: assessment of the magnetic properties. Magn Reson Med 1996;35:201-206.
12. Colet JM, Muller RN. Effects of opsonins on the uptake of magnetic starch microspheres by rat Kupffer cells. MAGMA 1994;2:303-305.
13. Colet JM. Study of the mechanisms of hepatic internalization of molecular and nanoparticular systems, contrast agents for magnetic resonance imaging. Ph.D. Thesis, University of MonsHainaut, Mons, Belgium, 1995.
14. Altman DG. In: Practical statistics for medical research. London: Chapman & Hall; 1995. p 210-212.
15. Armitage FE, Richardson DE, Li KCP. Polymeric contrast agents for magnetic resonance imaging: synthesis and characterization of gadolinium diethylenetriamine pentaacetic acid conjugated to polysaccharides. Bioconjugate Chem 1990;1:365-374.
16. 3+: relaxivities as function of molecular weight and conjugation efficiency. Magn Reson Imaging 1992;10:913-917.
17. Bertini I, Capozzi F, Luchinat C, Nicastro G, Xia Z. Water proton relaxation for some lanthanide aqua ions in solution. J Phys Chem 1993;97:6351-6354.
18. Fossheim SL, Spiller M, Kellar KE. NMRD investigation of Dy-DTPA-and Gd-DTPA-labeled starch particles: selection of a suitable suspension medium and influence of the starch matrix on relaxivity. Invest Radiol (in press).
19. Koenig SH, Brown RD III, Ugolini R. A unified view of relaxation in protein solutions and tissue, including hydration and magnetization transfer. Magn Reson Med 1993;29:77-83.
20. Koenig SH, Brown RD III, Ugolini R. Magnetization transfer in cross-linked bovine serum albumin solutions at 200 MHz: a model for tissue. Magn Reson Med 1993;29:311-316.
21. Roitt IM. Innate immunity. In: Roitt IM, editor. Essential immunology. Oxford, England: Blackwell Scientific Publications; 1994. p 3-20.
22. Chouly C, Pouliquen D, Lucet I, Jeune JJ, Jallet P. Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution. J Microencapsulation 1996;13:245-255.
23. Harashima H, Kiwada H. Liposomal targeting and drug delivery: kinetic consideration. Adv Drug Deliv Rev 1996;19:425-444.
24. Liu D. Animal species-dependent liposome clearance. J Liposome Res 1996;6:77-97.
25. Laakso T, Smedsrød B. Cellular distribution in rat liver of intravenously administered polyacryl starch and chondroitin sulfate microparticles. Int J Pharmacol 1987;36:253-262.
26. Rongved P, Hauk Fritzell T, Strande P, Klaveness J. Polysaccharides as carriers for magnetic resonance imaging contrast agents: synthesis and stability of a new amino acid linker derivative. Carbohydr Res 1996;287:77-89.
27. Tuma RF. The use of degradable starch microspheres for transient occlusion of blood flow and for drug targeting to selected tissues. In: Davis SS, Illum L, Mc Vie JG, Tomlinson E, editors. Microspheres and drug therapy: pharmaceutical, immunological and medical aspects. Amsterdam: Elsevier; 1984. p 189-203.
28. 2+ to murine liver. Magn Reson Med 1990;13:44-61.
29. Blouin A, Bolender RP, Weibel ER. Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma: a stereological study. J Cell Biol 1977;72:441-455.
30. Fahlvik AK, Holtz E, Klaveness J. Relaxation efficacy of paramagnetic and superparamagnetic microspheres in liver and spleen. Magn Reson Imaging 1990;8:363-369.
31. Fossheim SL, Colet JM, Månsson S, Fahlvik AK, Muller RN, Klaveness J. Paramagnetic liposomes as MRI contrast agents: assessment of contrast efficacy in various liver models. Invest Radiol 1999;33:810-821.
32. Magin RL, Bacic G, Niesman MR, Alameda JC Jr, Wright SM, Scwartz HM. Dextran magnetite as a liver contrast agent. Magn Reson Med 1991;20:1-16.
33. Ganong WF. Pulmonary function. In: Ganong WF, editor. Review of medical physiology. East Norwalk, CT: Apple & Lange; 1989. p 547-562.
34. Unger EC, Fritz TA, Tilcock C, New TE. Clearance of liposomal gadolinium: in vivo decomplexation. J Magn Reson Imaging 1991;1: 689-693.