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2-Bromo-4-chloropyridine was also used. But although monosubstituted pyridine 6b was successfully obtained, the incorporation of the substituent at position 4 was hampered by the low reactivity of the chlorine atom under different Sonogashira reaction conditions. See the Supporting Information for further details.
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3) but its reactivity was low at 25°C, and even at 95°C after 68 h, conversion was not complete and selectivity was low, this being attributable to the methyl cis to the C-metal bond. Besides, this C-metal bond is very labile.
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27
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0242459917
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Different mixtures of 13 and 3 were used as starting material. See the Supporting Information for details.
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