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Volumn 7, Issue 25, 2005, Pages 5737-5739

Convergent stereoselective synthesis of the visual pigment A2E

Author keywords

[No Author keywords available]

Indexed keywords

A2E COMPOUND; COLORING AGENT; PALLADIUM; PYRIDINIUM DERIVATIVE; RETINOID;

EID: 29444449447     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol052512u     Document Type: Article
Times cited : (24)

References (31)
  • 20
    • 84888804985 scopus 로고    scopus 로고
    • note
    • 2-Bromo-4-chloropyridine was also used. But although monosubstituted pyridine 6b was successfully obtained, the incorporation of the substituent at position 4 was hampered by the low reactivity of the chlorine atom under different Sonogashira reaction conditions. See the Supporting Information for further details.
  • 21
    • 84888796509 scopus 로고
    • 2,4-Dibromopyridine was prepared by using a modified version of the method reported by den Hertog: den Hertog, H. J. Recl. Trav. Chim. 1944, 63, 85.
    • (1944) J. Recl. Trav. Chim. , vol.63 , pp. 85
    • Den Hertog, H.1
  • 24
    • 84888799026 scopus 로고    scopus 로고
    • note
    • 3) but its reactivity was low at 25°C, and even at 95°C after 68 h, conversion was not complete and selectivity was low, this being attributable to the methyl cis to the C-metal bond. Besides, this C-metal bond is very labile.
  • 27
    • 0242459917 scopus 로고    scopus 로고
    • - was used, instead, a complex mixture of products was obtained, probably due to its higher nucleophilic character. Simpkins, S. M. E.; Kariuki, B. M.; Aricó, C. S.; Cox, L. R. Org. Lett. 2003, 5, 3971.
    • (2003) Org. Lett. , vol.5 , pp. 3971
    • Simpkins, S.M.E.1    Kariuki, B.M.2    Aricó, C.S.3    Cox, L.R.4
  • 30
    • 84888789439 scopus 로고    scopus 로고
    • note
    • Different mixtures of 13 and 3 were used as starting material. See the Supporting Information for details.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.