Alterations to the decision-making processes linked to the ventromedial prefrontal cortex in drug-abusing patients;Alteraciones de los procesos de toma de decisiones vinculados al córtex prefrontal ventromedial en pacientes drogodependientes

Revista de Neurologia

Volumn 38, Issue 7, 2004, Pages 601-606

  Verdejo, Antonio ^a   Aguilar De Arcos, F ^a   Perez Garcia M ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

Decision making; Drug abuse; Gambling task; Neuropsychological impairment; Somatic markers; Ventromedial cortex

Indexed keywords

ADULT; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DECISION MAKING; DRUG ABUSE; FEMALE; HABITUATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROTOXICITY; PATHOLOGICAL GAMBLING; PREFRONTAL CORTEX; SUBSTANCE ABUSE; TASK PERFORMANCE;

EID: 2942750194     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3807.2003639     Document Type: Article

References (34)

1. Damasio AR. Descartes' error: emotion, reason, and the human brain. New York: Grosset/Putnam; 1994.
2. Bechara A, Damasio H, Damasio AR. Emotion, decision-making and the orbitofrontal cortex. Cereb Cortex 2000; 10: 295-307.
3. Bechara A, Damasio H, Damasio AR, Anderson SW. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 1994; 50: 7-15.
4. Bechara A, Tranel D, Damasio H. Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain 2000; 123: 2189-202.
5. Bechara A, Tranel D, Damasio H, Damasio AR. Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex. Cereb Cortex 1996; 6: 215-25.
6. Manes F, Sahakian B, Clark L, Rogers R, Antoun N, Aitken M, et al. Decision-making processes following damage to the prefrontal cortex. Brain 2002; 125: 624-39.
7. Bechara A, Dolan S, Denburg N, Hindes A, Anderson SW, Nathan PE. Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia 2001; 39: 376-89.
8. Bartzokis G, Lu PH, Beckson M, Rapoport R, Grant S, Wiseman EJ, et al. Abstinence from cocaine reduces high-risk responses on a Gambling Task. Neuropsychopharmacology 2000; 22: 102-3.
9. Bechara A, Damasio H. Decision-making and addiction (part I): impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences. Neuropsychologia 2002; 40: 1675-89.
10. Bechara A, Dolan S, Hindes A. Decision-making and addiction (part II): myopia for the future or hypersensitivity to reward? Neuropsychologia 2002; 40: 1690-705.
11. Grant S, Conttoreggi C, London ED. Drug abusers show impaired performance in a laboratory test of decision-making. Neuropsychologia 2000; 38: 1180-7.
12. Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K, et al. Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology 1999; 20: 322-39.
13. Bolla KI, Eldreth DA, London ED, Kiehl KA, Mouraditis M, Contoreggi C, et al. Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 2003; 19: 1085-94.
14. Paulus MP, Hozack NE, Zauscher BE, Frank L, Brown GG, Braff DL, et al. Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects. Neuropsychopharmacology 2002; 26: 53-62.
15. Cowan RL, Lyoo IK, Sung SO, Ahn KH, Kim MJ, Hwang J, et al. Reduced cortical grey matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study. Drug Alcohol Dep 2003; 72: 225-35.
16. Franklin TR, Acton PD, Maldjian JA, Gray JD, Croft JR, Dackis CA, et al. Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol Psychiatry 2002; 51: 134-42.
17. Adinoff B, Devous MD, Best SM, George MS, Alexander D, Payne K. Limbic responsiveness to procaine in cocaine-addicted subjects. Am J Psychiatry 2001; 158: 390-8.
18. Daglish MRC, Weinstein A, Malizia AL, Wilson S, Melichar JK, Britten S, et al. Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects. Am J Psychiatry 2001; 158: 1680-6.
19. Grant S, London ED, Newlin DB, Villemagne VL, Liu X, Contoreggi C, et al. Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci U S A 1996; 93: 12040-5.
20. Sell LA, Morris JS, Bearn J, Frackowiak RSJ, Friston KJ, Dolan RJ. Neural responses associated with cue evoked emotional states and heroin in opiate addicts. Drug Alcohol Dep 2000; 60: 207-16.
21. Verdejo-García A, Orozco C, Meersmans M, Aguilar de Arcos F, Pérez-García M. Impacto de la severidad del consumo de drogas de abuso sobre distintos componentes de la función ejecutiva. Rev Neurol [in process]
22. Verdejo-García A, Aguilar de Arcos F, Sánchez-Barrera M, Pérez-García M. Deterioro de los procesos de toma de decisiones en una muestra de drogodependientes. In: Cerebro y Adicciones. Madrid: Mapfre; 2003; p: 421-34.
23. Monterosso J, Ehrman R, Napier K, O'Brien CP, Childress AR. Three decision-making tasks in cocaine-dependent patients: do they measure the same construct? Addiction 2001; 96: 1825-37.
24. Jentsch JD, Taylor JR. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implication for the control of behavior by reward-related stimuli. Psychopharmacology 1999; 146: 373-90.
25. Goldstein RZ, Volkow ND. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 2002; 159: 1642-52.
26. Verdejo-Garcá A, Sánchez-Barrera M, Aguilar de Arcos F, Pérez-García M. Relation between a decision-making instrument and a measure of the experience of emotions in substance abusers. Addiction [in process].
27. Armstrong TD, Costello EJ. Community studies on adolescent substance use, abuse, or dependence and psychiatric comorbidity. J Consult Clin Psychol 2002; 6: 1224-39.
28. Flory K, Lynam DR. The relation between attention deficit hyperactivity disorder and substance abuse: What role does conduct disorder play? Clin Child Fam Psychol Rev 2003; 6: 1-14.
29. Modestin J, Matutat B, Würmle O. Antecedents of opioid dependence and personality disorder: attention deficit/hyperactivity disorder and conduct disorder. Eur Arch Psychiatry Clin Neurosci 2001; 251: 42-7.
30. Ernst M, Grant SJ, London ED, Kimes AS, Spurgeon L. Decision-making in adolescents with behavior disorders and adults with substance abuse. Am J Psychiatry 2003; 160: 33-40.
31. Volkow ND, Wang G-J, Fowler JS, Logan J, Franceschi D, Maynard L, et al. Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications. Synapse 2002; 43: 181-7.
32. 2 receptors levels. Am J Psychiatry 1999; 156: 1440-3.
33. 2 receptors. J Pharmacol Exp Ther 1999; 291: 409-15.
34. Bechara A, Damasio H, Damasio AR. Manipulation of dopamine and serotonin causes differential effects on covert and overt decision-making. Abstr Soc Neurosci 2001; 27: 126.