Oligomeric assembly of native-like precursors precedes amyloid formation by β-2 microglobulin

Biochemistry

Volumn 43, Issue 24, 2004, Pages 7808-7815

  Eakin, Catherine M ^a   Attenello, Frank J ^a   Morgan, Charles J ^a,b   Miranker, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

^b GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; DIMERS; MOLECULAR STRUCTURE; MONOMERS; NATURAL FIBERS; OLIGOMERS;

AMYLOID;

BIOCHEMICAL ENGINEERING;

AMYLOID; BETA 2 MICROGLOBULIN; COPPER ION; PROTEIN PRECURSOR;

ARTICLE; CIRCULAR DICHROISM; DIMERIZATION; HEMODIALYSIS; IN VITRO STUDY; KIDNEY FAILURE; MOLECULAR SIZE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; WILD TYPE;

AMYLOID; BETA 2-MICROGLOBULIN; BIOPOLYMERS; CIRCULAR DICHROISM; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 2942748436     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049792q     Document Type: Article

References (39)

1. Rochet, J. C., and Lansbury, P. T., Jr. (2000) Amyloid fibrillogenesis: themes and variations, Curr. Opin. Struct. Biol. 10, 60-68.
2. Sunde, M., Serpell, L. C., Bartlam, M., Fraser, P. E., Pepys, M. B., and Blake, C. C. (1997) Common core structure of amyloid fibrils by synchrotron X-ray diffraction, J. Mol. Biol. 273, 729-739.
3. Harper, J. D., and Lansbury, P. T., Jr. (1997) Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins, Annu. Rev. Biochem. 66, 385-407.
4. Hardy, J., and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science 297, 353-356.
5. Floege, J., and Ehlerding, G. (1996) Beta-2-microglobulin-associated amyloidosis, Nephron 72, 9-26.
6. Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., and Wiley, D. C. (1987) Structure Of the Human Class-I Histocompatibility Antigen, Hla-A2, Nature 329, 506-512.
7. Malaguarnera, M., Restuccia, S., Di Fazio, I., Zoccolo, A. M., Trovato, B. A., and Pistone, G. (1997) Serum beta2-microglobulin in chronic hepatitis C, Dig. Dis. Sci. 42, 762-766.
8. Keating, M. J. (1999) Chronic lymphocytic leukemia, Semin. Oncol. 26, 107-114.
9. Morgan, C. J., Gelfand, M., Atreya, C., and Miranker, A. D. (2001) Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation, J. Mol. Biol. 309, 339-345.
10. Eakin, C. M., Knight, J. D., Morgan, C. J., Gelfand, M. A., and Miranker, A. D. (2002) Formation of a copper specific binding site in non-native states of beta-2-microglobulin, Biochemistry 41, 10646-10656.
11. Jobling, M. F., Huang, X., Stewart, L. R., Bamham, K. J., Curtain, C., Volitakis, I., Perugini, M., White, A. R., Cherny, R. A., Masters, C. L., Barrow, C. J., Collins, S. J., Bush, A. I., and Cappai, R. (2001) Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126, Biochemistry 40, 8073-8084.
12. Wadsworth, J. D., Hill, A. F., Joiner, S., Jackson, G. S., Clarke, A. R., and Collinge, J. (1999) Strain-specific prion-protein conformation determined by metal ions, Nat. Cell. Biol. 1, 55-59.
13. Bush, A. I., and Tanzi, R. E. (2002) The galvanization of beta-amyloid in Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A. 99, 7317-7319.
14. Uversky, V. N., Li, J., and Fink, A. L. (2001) Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure, J. Biol. Chem. 276, 44284-44296.
15. Davis, D. P., Gallo, G., Vogen, S. M., Dul, J. L., Sciarretta, K. L., Kumar, A., Raffen, R., Stevens, F. J., and Argon, Y. (2001) Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain, J. Mol. Biol. 313, 1021-1034.
16. LeVine, H., 3rd. (1993) Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution, Protein Sci. 2, 404-410.
17. Schuck, P. (2000) Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling, Biophys. J. 78, 1606-1619.
18. Piotto, M., Saudek, V., and Sklenar, V. (1992) Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions, J. Biomol. NMR 2, 661-665.
19. Lapham, J., Rife, J. P., Moore, P. B., and Crothers, D. M. (1997) Measurement of diffusion constants for nucleic acids by NMR, J. Biomol. NMR 10, 255-262.
20. Uversky, V. N. (2002) Natively unfolded proteins: a point where biology waits for physics, Protein Sci. 11, 739-756.
21. Kahn, P. C. (1979) The interpretation of near-ultraviolet circular dichroism, Methods Enzymol. 61, 339-378.
22. Ubbink, M., Worrall, J. A., Canters, G. W., Groenen, E. J., and Huber, M. (2002) Paramagnetic resonance of biological metal centers, Annu. Rev. Biophys. Biomol. Struct. 31, 393-422.
23. Vorbeck-Meister, I., Sommer, R., Vorbeck, F., and Horl, W. H. (1999) Quality of water used for haemodialysis: bacteriological and chemical parameters, Nephrol. Dial. Transplant. 14, 666-675.
24. Andrianantoandro, E., Blanchoin, L., Sept, D., McCammon, J. A., and Pollard, T. D. (2001) Kinetic mechanism of end-to-end annealing of actin filaments, J. Mol. Biol. 312, 721-730.
25. Rothwell, S. W., Grasser, W. A., and Murphy, D. B. (1986) End-to-end annealing of microtubules in vitro, J. Cell Biol. 102, 619-627.
26. Liu, Y., and Eisenberg, D. (2002) 3D domain swapping: as domains continue to swap, Protein Sci. 11, 1285-1299.
27. Sinha, N., Tsai, C. J., and Nussinov, R. (2001) A proposed structural model for amyloid fibril elongation: domain swapping forms an interdigitating beta-structure polymer, Protein Eng. 14, 93-103.
28. Liu, Y., Gotte, G., Libonati, M., and Eisenberg, D. (2001) A domain-swapped RNase A dimer with implications for amyloid formation, Nat. Struct. Biol. 8, 211-214.
29. Cohen, F. E., and Prusiner, S. B. (1998) Pathologic conformations of prion proteins, Annu. Rev. Biochem. 67, 793-819.
30. Knaus, K. J., Morillas, M., Swietnicki, W., Malone, M., Surewicz, W. K., and Yee, V. C. (2001) Crystal structure of the human prion protein reveals a mechanism for oligomerization, Nat. Struct. Biol. 8, 770-774.
31. Staniforth, R. A., Giannini, S., Higgins, L. D., Conroy, M. J., Hounslow, A. M., Jerala, R., Craven, C. J., and Waltho, J. P. (2001) Three-dimensional domain swapping in the folded and molten-globule states of cystatins, an amyloid-forming structural superfamily, EMBO J. 20, 4774-4781.
32. Sanders, A., Jeremy Craven, C., Higgins, L. D., Giannini, S., Conroy, M. J., Hounslow, A. M., Waltho, J. P., and Staniforth, R. A. (2004) Cystatin forms a Tetramer through Structural Rearrangement of Domain-swapped Dimers prior to Amyloidogenesis, J. Mol. Biol. 336, 165-178.
33. Jones, S., Smith, D. P., and Radford, S. E. (2003) Role of the N-and C-terminal strands of beta 2-microglobulin in amyloid formation at neutral pH, J. Mol. Biol. 330, 935-941.
34. Esposito, G., Michelutti, R., Verdone, G., Viglino, P., Hernandez, H., Robinson, C. V., Amoresano, A., Dal Piaz, F., Monti, M., Pucci, P., Mangione, P., Stoppini, M., Merlini, G., Ferri, G., and Bellotti, V. (2000) Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation, Protein Sci. 9, 831-845.
35. McParland, V. J., Kalverda, A. P., Homans, S. W., and Radford, S. E. (2002) Structural properties of an amyloid precursor of beta-(2)-microglobulin, Nat. Struct. Biol. 9, 326-331.
36. Laity, J. H., Lee, B. M., and Wright, P. E. (2001) Zinc finger proteins: new insights into structural and functional diversity, Curr. Opin. Struct. Biol. 11, 39-46.
37. Miura, T., Suzuki, K., Kohata, N., and Takeuchi, H. (2000) Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes, Biochemistry 39, 7024-7031.
38. Aronoff-Spencer, E., Burns, C. S., Avdievich, N. I., Gerfen, G. J., Peisach, J., Antholine, W. E., Ball, H. L., Cohen, F. E., Prusiner, S. B., and Millhauser, G. L. (2000) Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy, Biochemistry 39, 13760-13771.
39. Brown, D. R. (2001) Copper and prion disease, Brain Res. Bull. 55, 165-173.