Contrasting effects of urokinase and tissue-type plasminogen activators on neointima formation and vessel remodelling after arterial injury

Journal of Vascular Research

Volumn 41, Issue 3, 2004, Pages 268-276

  Parfyonova, Yelena ^a   Plekhanova, Olga ^a   Solomatina, Marina ^a   Naumov, Vladimir ^a   Bobik, Alex ^b   Berk, Bradford ^c   Tkachuk, Vsevolod ^a  

^a INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Migration; Neointima; Plasminogen activators; Proteolysis; Vessel injury

Indexed keywords

ALPHA 2 ANTIPLASMIN; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTICLE; BALLOON CATHETER; CAROTID ARTERY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; HEALING; IMMUNOHISTOCHEMISTRY; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE REPAIR; TISSUE SPECIFICITY;

ANIMALS; CAROTID ARTERY INJURIES; CELL COUNT; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PLASMINOGEN ACTIVATORS; RATS; RATS, INBRED WKY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TUNICA INTIMA; URINARY PLASMINOGEN ACTIVATOR;

EID: 2942726214     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000078825     Document Type: Article

References (42)

1. Libby P, Schwartz D, Brogi E, Tanaka H, Clinton SK: A cascade model for restenosis. A special case of atherosclerosis progression. Circulation 1992;86:III47-III52.
2. Narins CR, Holmes DR, Topol EJ: A call for provisional stenting: The balloon is back! Circulation 1998;97:1298-1305.
3. Schwartz RS: Pathophysiology of restenosis: Interaction of thrombosis, hyperplasia, and/or remodelling. Am J Cardiol 1998;81:14E-17E.
4. Clowes AW, Reidy MA: Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia - A review. J Vasc Surg 1991;13:885-891.
5. Reidy MA, Irvin C, Lindner V: Migration of arterial wall cells. Expression of plasminogen activators and inhibitors in injured rat arteries. Circ Res 1996;78:405-414.
6. Tkachuk V, Stepanova V, Little PJ, Bobik A: Regulation and role of urokinase plasminogen activator in vascular remodelling. Clin Exp Pharmacol Physiol 1996;23:759-765.
7. Clowes AW, Clowes MM, Au YP, Reidy MA, Belin D: Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res 1990;67:61-67.
8. Carmeliet P, Moons L, Herbert JM, Crawley J, Lupu F, Lijnen R, Collen D: Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice. Circ Res 1997;81:829-839.
9. Parfyonova YV, Plekhanova OS, Tkachuk VA: Plasminogen activators in vascular remodelling and angiogenesis. Biochemistry (Mosc) 2002;67:119-134.
10. Collen D: Ham-Wasserman lecture: Role of the plasminogen system in fibrin-homeostasis and tissue remodelling. Hematology (Am Soc Hematol Educ Program) 2001;1:1-9.
11. Fearns C, Samad F, Loskutoff DJ: Advances in vascular biology; in van Hinsbergh VWM (ed): Vascular Control of Hemostasis. Reading, Harwood Academic Publishers, 1996, pp 207-227.
12. Matsuno H, Kozawa O, Niwa M, Ueshima S, Matsuo O, Collen D, Uematsu T: Differential role of components of the fibrinolytic system in the formation and removal of thrombus induced by endothelial injury. Thromb Haemost 1999;81:601-604.
13. Schafer K, Konstantinides S, Riedel C, Thinnes T, Muller K, Dellas C, Hasenfuss G, Loskutoff DJ: Different mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator. Circulation 2002;106:1847-1852.
14. Carmeliet P, Moons L, Dewerchin M, Mackman N, Luther T, Breier G, Ploplis V, Muller M, Nagy A, Plow E, Gerard R, Edgington T, Risau W, Collen D: Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system. Ann NY Acad Sci 1997;811:191-206.
15. Plekhanova OS, Parfyonova YV, Bibilashvily RS, Stepanova VV, Erne P, Bobik A, Tkachuk VA: Urokinase plasminogen activator enhances neointima growth and reduces lumen size in injured carotid arteries. J Hypertens 2000;18:1065-1069.
16. Plekhanova O, Parfyonova Y, Bibilashvily R, Domogatskii S, Stepanova V, Gulba DC, Agrotis A, Bobik A, Tkachuk V: Urokinase plasminogen activator augments cell proliferation and neointima formation in injured arteries via proteolytic mechanisms. Atherosclerosis 2001;159:297-306.
17. Stepanova V, Bobik A, Bibilashvily R, Belogurov A, Rybalkin I, Domogatsky S, Little PJ, Goncharova E, Tkachuk V: Urokinase plasminogen activator induces smooth muscle cell migration: Key role of growth factor-like domain. FEBS Lett 1997;414:471-474.
18. Mukhina S, Stepanova V, Traktouev D, Poliakov A, Beabealashvilly R, Gursky Y, Minashkin M, Shevelev A, Tkachuk V: The chemotactic action of urokinase on smooth muscle cells is dependent on its kringle domain. Characterization of interactions and contribution to chemotaxis. J Biol Chem 2000;275:16450-16458.
19. Herbert JM, Lamarche I, Carmeliet P: Urokinase and tissue-type plasminogen activator are required for the mitogenic and chemotactic effects of bovine fibroblast growth factor and platelet-derived growth factor-BB for vascular smooth muscle cells. J Biol Chem 1997;272:23585-23591.
20. Carmeliet P, Moons L, Lijnen R, Baes M, Lemaitre V, Tipping P, Drew A, Eeckhout Y, Shapiro S, Lupu F, Collen D: Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nat Genet 1997;17:439-444.
21. Estreicher A, Muhlhauser J, Carpentier JL, Orci L, Vassalli JD: The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol 1990;111:783-792.
22. Mulvany MJ, Baumbach GL, Aalkjaer C, Heagerty AM, Korsgaard N, Schiffrin EL, Heistad DD: Vascular remodelling. Hypertension 1996;28:505-506.
23. Copeta A, Tavian D, Marchina E, De P, Barlati S: Gene response of human skin fibroblasts to urokinase- and tissue-type plasminogen activators. Growth Factors 2000;17:249-268.
24. Herbert JM, Lamarche I, Prabonnaud V, Dol F, Gauthier T: Tissue-type plasminogen activator is a potent mitogen for human aortic smooth muscle cells. J Biol Chem 1994;269:3076-3080.
25. Jackson CL, Raines EW, Ross R, Reidy MA: Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury. Arterioscler Thromb 1993;13:1218-1226.
26. Angles C: Overview on fibrinolysis: Plasminogen activation pathways on fibrin and cell surfaces. Chem Phys Lipids 1994;67/68:353-362.
27. Lijnen HR, Van H, Lupu F, Moons L, Carmeliet P, Collen D: Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes. Arterioscler Thromb Vasc Biol 1998;18:1035-1045.
28. Collen D, Lijnen HR: Basic and clinical aspects of fibrinolysis and thrombolysis. Blood 1991;78:3114-3124.
29. Hasenstab D, Lea H, Hart CE, Lok S, Clowes AW: Tissue factor overexpression in rat arterial neointima models thrombosis and progression of advanced atherosclerosis. Circulation 2000;101:2651-2657.
30. Jenkins GM, Crow MT, Bilato C, Gluzband Y, Ryu WS, Li Z, Stetler S, Nater C, Froehlich JP, Lakatta EG, Cheng L: Increased expression of membrane-type matrix metalloproteinase and preferential localization of matrix metalloproteinase-2 to the neointima of balloon-injured rat carotid arteries. Circulation 1998;97:82-90.
31. Cho A, Reidy MA: Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury. Circ Res 2002;91:845-851.
32. Keski O, Lohi J, Tuuttila A, Tryggvason K, Vartio T: Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator. Exp Cell Res 1992;202:471-476.
33. Menshikov M, Elizarova E, Plakida K, Timofeeva A, Khaspekov G, Beabealashvilli R, Bobik A, Tkachuk V: Urokinase upregulates matrix metalloproteinase-9 expression in THP-1 monocytes via gene transcription and protein synthesis. Biochem J 2002;367:833-839.
34. Wells JM, Strickland S: Regulated localization confers multiple functions on the protease urokinase plasminogen activator. J Cell Physiol 1997;171:217-225.
35. Agrotis A, Bobik A: Vascular remodelling and molecular biology: New concepts and therapeutic possibilities. Clin Exp Pharmacol Physiol 1996;23:363-368.
36. Lindner V, Reidy MA: Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries. An en face study. Circ Res 1993;73:589-595.
37. Ding H, Wang R, Marcel R, Fisher DZ: Adenovirus-mediated expression of a truncated PDGFbeta receptor inhibits thrombosis and neointima formation in an avian arterial injury model. Thromb Haemost 2001;86:914-922.
38. Smith JD, Bryant SR, Couper LL, Vary CP, Gotwals PJ, Koteliansky VE, Lindner V: Soluble transforming growth factor-beta type II receptor inhibits negative remodelling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth. Circ Res 1999;84:1212-1222.
39. Li G, Chen SJ, Oparil S, Chen YF, Thompson JA: Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts after balloon injury of rat carotid arteries. Circulation 2000;101:1362-1365.
40. Shah PK: Inflammation, neointimal hyperplasia, and restenosis: As the leukocytes roll, the arteries thicken. Circulation 2003;107:2175-2177.
41. Mori E, Komori K, Yamaoka T, Tanii M, Kataoka C, Takeshita A, Usui M, Egashira K, Sugimachi K: Essential role of monocyte chemoattractant protein-1 in development of restenotic changes (neointimal hyperplasia and constrictive remodelling) after balloon angioplasty in hypercholesterolemic rabbits. Circulation 2002;105:2905-2910.
42. Nassar T, Akkawi S, Shina A, Haj-Yehia A, Bdeir K, Tarshis M, Heyman SN, Higazi AA: The in vitro and in vivo effect of tPA and PAI-1 on blood vessel tone. Blood 2004;103:897-902.