New phenolic inhibitors of yeast homoserine dehydrogenase

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 14, 2004, Pages 3825-3830

  Ejim, Linda ^a   Mirza, I Ahmad ^b   Capone, Christina ^a   Nazi, Ishac ^a   Jenkins, Steve ^a   Chee, Gaik Lean ^c   Berghuis, Albert M ^b   Wright, Gerard D ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Crompton Co/Cie   (Canada)

Author keywords

Amino acid biosynthesis; Antifungal; Small molecule screening; X ray

Indexed keywords

AMIDE; AMINO ACID; ENZYME INHIBITOR; GLYCINE; HOMOSERINE DEHYDROGENASE; HYDROXYL GROUP; PHENOL DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; INHIBITION KINETICS; MOLECULAR SIZE; NONHUMAN; SCREENING; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; YEAST;

ANTIFUNGAL AGENTS; CANDIDA; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HOMOSERINE DEHYDROGENASE; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PHENOLS; SACCHAROMYCES CEREVISIAE;

EID: 2942726186     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.05.009     Document Type: Article

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