Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice

Toxicological Sciences

Volumn 79, Issue 2, 2004, Pages 242-247

  Stott, W T ^a   Radtke, B J ^a   Linscombe, V A ^a   Mar, M H ^b   Zeisel, S H ^b  

^a DOW CHEMICAL COMPANY   (United States)

^b University of North Carolina   (United States)

Author keywords

Choline deficiency; Mechanism; Triethanolamine

Indexed keywords

ACETONE; BETAINE; CHOLINE; PHOSPHORYLCHOLINE; TRIETHANOLAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CANCER INCIDENCE; CHO CELL; CLINICAL EXAMINATION; CLINICAL FEATURE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER CANCER; LIVER CARCINOGENESIS; LIVER LEVEL; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; SEX DIFFERENCE; STATISTICAL ANALYSIS; VITAMIN DEFICIENCY;

ADMINISTRATION, TOPICAL; ANIMALS; BETAINE; CELLS, CULTURED; CHO CELLS; CHOLINE; CRICETINAE; CRICETULUS; ETHANOLAMINES; FEMALE; LIVER; MICE; MICE, INBRED STRAINS; PHOSPHORYLCHOLINE; RATS; RATS, INBRED F344; SPECIES SPECIFICITY; TRITIUM;

CRICETINAE; CRICETULUS GRISEUS; RODENTIA;

EID: 2942722788     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh115     Document Type: Article

References (24)

1. Akesson, B. (1977). Effects of analogues of ethanolamine and choline on phospholipid metabolism in rat hepatocytes. Biochem. J. 168, 401-408.
2. Barbee, S. J., and Hartung, R. (1979) The effect of diethanolamine on hepatic and renal phospholipid metabolism in the rat. Toxicol. Appl. Pharmacol. 47, 421-430.
3. Borman, L. S. (1982). Modulation of mammalian cell growth by a choline analog, N-isopropylethanoamine. In Vitro 18, 129-140.
4. Glaser, M., Ferguson, K. A., and Vagelos, P. R. (1974). Manipulation of the phospholipid composition of tissue culture cells. Proc. Nat. Acad Sci. U.S.A. 71, 4072-4076.
5. Kamendulis, L. M., Smith, D. J., Rao, Z., and Klaunig, J. E. (2003). Species differences in the induction of hepatocellular DNA synthesis by diethanolamine. The Toxicol. 72, Abstr. No. 1155.
6. Kamendulis, L. M., Smith, D. J., and Klaunig, J. E. (2002). Role of choline depletion in diethanolamine induced DNA synthesis in mouse hepatocytes. The Toxicol. 66, Abstr. No. 1507.
7. Knaak, J. B., Leung, H.-W., Stott, W. T., Busch J., and Bilsky, J. (1997). Toxicology of mono-, di-, and triethanolamine. Rev. Environ. Contam. Toxicol. 149, 1-86.
8. Konishi, Y., Denda, A., Uchida, K., Emi, Y., Ura, H., Yokose, Y., Shiraiwa, K., and Tsutsumi, M. (1992). Chronic toxicity carcinogenicity studies of triethanolamine in B6C3F1 mice. Fundam. Appl. Toxicol. 18, 25-29.
9. Koc, H., Mar, M.-H., Ranasinghe, A., Swenberg, J. A., and Zeisel, S. H. (2002). Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal. Chem. 74, 4734-4740.
10. Lehman-McKeeman, L. D., and Gamsky, E. A. (1999). Diethanolamine inhibits choline uptake and phosphatidylcholine synthesis in Chinese Hamster ovary cells. Biochem. Biophys. Res. Comm. 262, 600-604.
11. Lehman-McKeeman, L. D., and Gamsky, E. A. (2000). Choline supplementation inhibits diethanolamine-induced morphological transformation in Syrian Hamster embryo cells: Evidence for a carcinogenic mechanism. Toxicol. Sci. 55, 303-310.
12. Lehman-McKeeman, L. D., Gamsky, E. A., Hicks, S. M., Vassallo, J. D., Mar, M.-H., and Zeisel, S. H. (2002). Diethanolamine induces hepatic choline deficiency in mice. Toxicol. Sci. 67, 38-45.
13. Mathews, J. M., Garner C. E., Black, S. L., and Matthews H. B. (1997). Diethanolamine absorption, metabolism and disposition in rat and mouse following oral, intravenous and dermal administration. Xenobiotica 27, 733-746.
14. Mathews, J. M., Garner, C. E., and Matthews H. B. (1995). Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chem. Res. Toxicol. 8, 625-633.
15. National Toxicology Program (NTP) (1999a). Toxicology and Carcinogenesis Studies of Triethanolamine (CAS No. 102-71-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies), NTP TR 449, NIH Publication No. 00-3365.
16. National Toxicology Program (NTP) (1999b). Toxicology and Carcinogenesis Studies of Diethanolamine (CAS No. 111-42-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies), NTP TR 478, NIH Publication No. 97-3968.
17. National Toxicology Program (NTP) (2003). Toxicology and Carcinogenesis Studies of Triethanolamine (CAS No. 102-71-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies), NTP TR 518, NIH Publication No. 03-4452.
18. Pelech, S. L., and Vance, D. E. (1984). Regulation of phosphatidylcholine biosynthesis. Biochim. Biophys. Acta 779, 217-251.
19. Steel, R. G. D., and J. H. Torrie. (1960). Principles and Procedures of Statistics. McGraw-Hill, New York.
20. Stott, W. T., Bartels, M. J., Brzak, K. A., Mar, M.-H., Markham, D. A., Thornton, C. M., and Zeisel, S. H. (2000a). Potential mechanisms of tumorigenic action of diethanolamine in mice. Toxicol. Lett. 114, 67-75.
21. Stott, W. T., Bartels, M. J., Brzak, K. A., Mar, M.-H., Markham, D. A., Thornton, C. M., Kan, L., Curry, S., Purdon, M., and Zeisel, S. H. (2000b). Potential mechanisms of tumorigenic action of diethanolamine in mice. The Toxicol. 54, Abstr. No. 1022.
22. Stott, W. T., Waechter, J. M., Jr., Rick, D. L., and Mendrala, A. L. (2000c). Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food Chem. Toxicol. 38, 1043-1051.
23. Winer, B. J. (1971). Statistical Principles in Experimental Design, 2nd ed. McGraw-Hill, New York.
24. Zeisel, S. H., and Blusztajn, J. K. (1994). Choline and human nutrition. Ann. Rev. Nutr. 14, 269-296.