Potential mechanisms of tumorigenic action of diethanolamine in mice

Toxicology Letters

Volumn 114, Issue 1-3, 2000, Pages 67-75

  Stott, W T ^a   Bartels, M J ^a   Brzak, K A ^a   Mar, M H ^b   Markham, D A ^a   Thornton, C M ^a   Zeisel, S H ^b  

^a DOW CHEMICAL COMPANY   (United States)

^b IL   (United States)

Author keywords

Choline deficiency; Diethanolamine; Mechanism tumorigenesis; N Nitrosodiethanolamine

Indexed keywords

BIS(2 HYDROXYETHYL)NITROSAMINE; CHOLINE; DIETHANOLAMINE; GLYCEROPHOSPHORYLCHOLINE; PHOSPHOLIPID; PHOSPHORYLCHOLINE; SODIUM NITRITE;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; BLOOD LEVEL; CARCINOGENICITY; CONTROLLED STUDY; LIVER TUMOR; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ABSORPTION; STOMACH CONTENT; URINE LEVEL; VITAMIN DEFICIENCY;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARCINOGENS; CHOLINE; CHOLINE DEFICIENCY; DIETHYLNITROSAMINE; ETHANOLAMINES; GASTROINTESTINAL CONTENTS; GLYCERYLPHOSPHORYLCHOLINE; LIVER; MALE; MICE; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHORYLCHOLINE; SODIUM NITRITE; SPHINGOMYELINS;

EID: 0034599867     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00197-6     Document Type: Article

References (23)

1. Barbee S.J., Hartung R. The effect of diethanolamine on hepatic and renal phospholipid metabolism in the rat. Toxicol. Appl. Pharmacol. 47:1979;421-430.
2. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:1959;911-917.
3. DeCarmargo J.L.V., Punyarit P., Newberne P. Early stages of nodular transformation of the B6C3F1 mouse liver induced by choline deficiency. Toxicol. Pathol. 13:1985;10-17.
4. ECETOC, 1990. Human Exposure to N-Nitrosamines, Their Effects, and a Risk Assessment for N-Nitrosodiethanolamine in Personal Care Products. Technical Report No. 41 of the European Chemical Industry Ecology and Toxicology Centre, Brussels.
5. Goodman J.I., Ward J.M., Popp J.A., Klaunig J.E., Fox T.R. Mouse liver carcinogenesis: mechanisms and relevance. Fundam. Appl. Toxicol. 17:1991;651-665.
6. Knaak J.B., Leung H.-W., Stott W.T., Busch J., Bilsky J. Toxicology of mono-, di-, and triethanolamine. Rev. Environ. Contam. Toxicol. 149:1997;1-86.
7. Kerckaert G.A., Brauninger R., LeBoeuf R.A., Isfort R.J. Use of the Syrian hamster embryo cell transformaiton assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays. Environ. Health Perspect. (Suppl.). 104:1996;1075-1084.
8. Konishi, Y., Yokose, Y., Mori, Y., Yamazaki, H., Yamamoto, K., Nakajima, A., Denda, A., 1986. Lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine-related compounds and their formation in rats. In: Bartsch, H., O'Neill, I.K., Schulte-Hermann, R. (Eds.), Relevance of N-Nitroso Compounds to Human Cancer: Exposures and Mechanisms. IARC Sci. Publications #84, pp. 250-252.
9. Kramer C.Y. Extension of multiple range tests to group measurres with unequal numbers of replications. Biometrics. 12:1956;307-310.
10. Mathews J.M., Garner C.E., Mathews H.B. Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chem. Res. Toxicol. 8:1995;625-633.
11. Mathews J.M., Garner C.E., Black S.L., Mathews H.B. Diethanolamine absorption, metabolism and disposition in rat and mouse following oral, intravenous and dermal administration. Xenobiotics. 27:1997;733-746.
12. Newberne P.M., Rogers A.E. Labile methyl groups and the promotion of cancer. Ann. Rev. Nutr. 6:1986;407-432.
13. NTP, 1997. National Toxicology Program Technical Report on the Toxicology and Carcinogenesis Studies of Diethanolamine (CAS No. 111-42-2) in FF344/N Rats and B6C3F1 Mice (Dermal Studies). NTP TR 478, HIH Publication No. 97-3968.
14. Pomfret E.A., da Costa K.-A., Schurman L.L., Zeisel S.H. Measurement of choline and choline metabolite concentrations using HPLC and gas chromatography-mass spectrometry. Anal. Biochem. 180:1989;85-90.
15. Preussmann R., Spiegelhalder B., Eisenbrand G., Wurtele G., Hofmann I. Urinary excretion of N-nitrosodiethanolamine in rats following its epicutaneous and intratracheal administration and its formation in vivo following skin applications of diethanolamine. Cancer Lett. 13:1981;227-231.
16. Svanborg A., Svennerholm L. Plasma total lipids, cholesterol, triglycerides and free fatty acids in a healthy Scandinavian population. Acta Med. Scan. 169:1961;43-49.
17. Tennant R.W., Spalding J., French J.E. Evaluation of transgenic mouse bioassays for identifying carcinogens and noncarcinogens. Mutat. Res. 365:1996;119-127.
18. Wahle, B.S., Christenson, W.R., Lake, S.G., Elcock, L.E., Sangha, G.K., Thyssen, J.H., 1998. Carcinogenicity testing in the CD-1 mouse of a prospective insect repellant (KBR 3023) using the dermal route of exposure. The Toxicol. 42, Abstr. No. 771.
19. Winer B.J. Statistical Principles in Experimental Design. 2nd edition:1971;McGraw-Hill, New York.
20. Yamamoto K., Tsutsumi M., Kobayashi E., Endoh T., Noguchi O., Okajima E., Denda A., Mori Y., Konishi Y. Initiation of hepatocarcinogenesis by endogenously formed N-nitrosobis(2-hydroxypropyl)amine, N-nitrososdiethanolamine and N-nitroso-2,6-dimethylmorpholine in rats. Carcinogenesis. 16:1995;2633-2636.
21. Yen C.-L.E., Mar M.-H., Zeisel S.H. Choline deficiency-induced apoptosis in PC 12 cells is associated with diminished membrane phosphatidylcholine and sphiingomyelin, accumulation of ceramide and diacylglycerol, and activation of a caspase. FASEB J. 13:1999;135-142.
22. Zeisel S.H., Blusztajan J.K. Choline and human nutrition. Ann. Rev. Nutr. 14:1994;269-296.
23. Zeisel S.H., Mar M.-H., Zhou Z., da Costa K.-A. Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J. Nutr. 125:1995;3049-3054.