메뉴 건너뛰기




Volumn 97, Issue 6, 2004, Pages 270-274

GLP-1: Target for a new of antidiabetic agents?

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 6 [[2 [[2 (2 CYANO 1 PYRROLIDINYL) 2 OXOETHYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ENZYME INHIBITOR; EXANATIDE; EXENDIN 4; FE 999011; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; ISOLEUCINE THIAZOLIDIDE; LIRAGLUTIDE; METFORMIN; NATEGLINIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIOGLITAZONE; REPAGLINIDE; ROSIGLITAZONE; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

EID: 2942711823     PISSN: 01410768     EISSN: None     Source Type: Journal    
DOI: 10.1258/jrsm.97.6.270     Document Type: Review
Times cited : (11)

References (72)
  • 1
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53
    • (1998) Lancet , vol.352 , pp. 837-853
  • 2
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65
    • (1998) Lancet , vol.352 , pp. 854-865
  • 3
    • 0034901899 scopus 로고    scopus 로고
    • Contraindications to metformin therapy in patients with type 2 diabetes - A population-based study of adherence to prescribing guidelines
    • Emslie-Smith AM, Boyle DI, Evans JM, Sullivan F, Morris AD, for the DARTS/MEMO collaboration. Contraindications to metformin therapy in patients with type 2 diabetes - a population-based study of adherence to prescribing guidelines. Diabetic Med 2001;18:483-8
    • (2001) Diabetic Med , vol.18 , pp. 483-488
    • Emslie-Smith, A.M.1    Boyle, D.I.2    Evans, J.M.3    Sullivan, F.4    Morris, A.D.5
  • 6
    • 0001157424 scopus 로고
    • Sulphonylureas: Basic aspects and clinical uses
    • Alberti KGMM, Defronzo RA, Keen H, Zimmet P, eds. Oxford: Alden Press
    • Lebovitz HE, Melander A. Sulphonylureas: basic aspects and clinical uses. In: Alberti KGMM, Defronzo RA, Keen H, Zimmet P, eds. International Textbook of Diabetes Mellitus, 1st edn. Oxford: Alden Press, 1992:745-72
    • (1992) International Textbook of Diabetes Mellitus, 1st Edn. , pp. 745-772
    • Lebovitz, H.E.1    Melander, A.2
  • 7
    • 0032511606 scopus 로고    scopus 로고
    • Some answers, more controversy, from UKPDS. United Kingdom Prospective Diabetes Study
    • Nathan DM. Some answers, more controversy, from UKPDS. United Kingdom Prospective Diabetes Study. Lancet 1998;352:832-3
    • (1998) Lancet , vol.352 , pp. 832-833
    • Nathan, D.M.1
  • 8
    • 0035904785 scopus 로고    scopus 로고
    • Insulinotropic meglitinide analogues
    • Dornhorst A. Insulinotropic meglitinide analogues. Lancet 2001;358:1709-16
    • (2001) Lancet , vol.358 , pp. 1709-1716
    • Dornhorst, A.1
  • 9
    • 0036736833 scopus 로고    scopus 로고
    • Efficacy and safety of nateglinide in type 2 diabetic patients with modest fasting hyperglycemia
    • Saloranta C, Hershon K, Ball M, Dickinson S, Holmes D. Efficacy and safety of nateglinide in type 2 diabetic patients with modest fasting hyperglycemia. J Clin Endocrinol Metab 2002;87:4171-6
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4171-4176
    • Saloranta, C.1    Hershon, K.2    Ball, M.3    Dickinson, S.4    Holmes, D.5
  • 10
    • 0029064970 scopus 로고
    • Multicenter, placebo-controlled trial comparing acarbose (BAY g 5421) with placebo, tolbutamide, and tolbutamide-plus-acarbose in non-insulin- dependent diabetes mellitus
    • Coniff RF, Shapiro JA, Seaton TB, Bray GA. Multicenter, placebo-controlled trial comparing acarbose (BAY g 5421) with placebo, tolbutamide, and tolbutamide-plus-acarbose in non-insulin-dependent diabetes mellitus. Am J Med 1995;98:443-51
    • (1995) Am J Med , vol.98 , pp. 443-451
    • Coniff, R.F.1    Shapiro, J.A.2    Seaton, T.B.3    Bray, G.A.4
  • 11
    • 0027983920 scopus 로고
    • Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
    • Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 1994;331:1188-93
    • (1994) N Engl J Med , vol.331 , pp. 1188-1193
    • Nolan, J.J.1    Ludvik, B.2    Beerdsen, P.3    Joyce, M.4    Olefsky, J.5
  • 13
    • 0033754530 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: A 6-month randomized placebo-controlled dose-response study
    • The Pioglitazone 001 Study Group
    • Aronoff S, Rosenblatt S, Braithwaite S, Egan JW, Mathisen AL, Schneider RL. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. The Pioglitazone 001 Study Group. Diabetes Care 2000;23:1605-11
    • (2000) Diabetes Care , vol.23 , pp. 1605-1611
    • Aronoff, S.1    Rosenblatt, S.2    Braithwaite, S.3    Egan, J.W.4    Mathisen, A.L.5    Schneider, R.L.6
  • 14
    • 0035339878 scopus 로고    scopus 로고
    • The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. A multicenter, randomized, double-blind, placebo-controlled trial
    • Yale JF, Valiquett TR, Ghazzi MN, Owens-Grillo JK, Whitcomb RW, Foyt HL. The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. A multicenter, randomized, double-blind, placebo-controlled trial. Ann Intern Med 2001;134:737-45
    • (2001) Ann Intern Med , vol.134 , pp. 737-745
    • Yale, J.F.1    Valiquett, T.R.2    Ghazzi, M.N.3    Owens-Grillo, J.K.4    Whitcomb, R.W.5    Foyt, H.L.6
  • 15
    • 0021864130 scopus 로고
    • New developments in the incretin concept
    • Creutzfeldt W, Ebert R. New developments in the incretin concept. Diabetologia 1985;28:565-73
    • (1985) Diabetologia , vol.28 , pp. 565-573
    • Creutzfeldt, W.1    Ebert, R.2
  • 16
    • 0027419106 scopus 로고
    • Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations
    • Nauck MA, Bartels E, Orskov C, Ebert R, Creutzfeldt W. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol Metab 1993;76:912-17
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 912-917
    • Nauck, M.A.1    Bartels, E.2    Orskov, C.3    Ebert, R.4    Creutzfeldt, W.5
  • 17
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • Scrocchi LA, Brown TJ, MaClusky N, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 1996;2:1254-8
    • (1996) Nat Med , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    MaClusky, N.3
  • 18
    • 0032960834 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: Studies with the antagonist exendin 9-39
    • Edwards CM, Todd JF, Mahmoudi M, et al. Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39. Diabetes 1999;48:86-93
    • (1999) Diabetes , vol.48 , pp. 86-93
    • Edwards, C.M.1    Todd, J.F.2    Mahmoudi, M.3
  • 19
    • 0030836364 scopus 로고    scopus 로고
    • Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf
    • Edwards CM, Edwards AV, Bloom SR. Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf. Exp Physiol 1997;82:709-16
    • (1997) Exp Physiol , vol.82 , pp. 709-716
    • Edwards, C.M.1    Edwards, A.V.2    Bloom, S.R.3
  • 20
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993;91:301-7
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 21
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus
    • Gutniak M, Orskov C, Holst JJ, Ahren B, Efendic S. Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 1992;326:1316-22
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Orskov, C.2    Holst, J.J.3    Ahren, B.4    Efendic, S.5
  • 22
    • 0035106978 scopus 로고    scopus 로고
    • Minireview: The glucagon-like peptides
    • Drucker DJ. Minireview: the glucagon-like peptides. Endocrinology 2001;142:521-7
    • (2001) Endocrinology , vol.142 , pp. 521-527
    • Drucker, D.J.1
  • 23
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly-isolated human islets
    • Farilla L, Bulotta A, Hirshberg B, et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly-isolated human islets. Endocrinology 2003;144:5149-58
    • (2003) Endocrinology , vol.144 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3
  • 24
    • 0026542396 scopus 로고
    • Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects
    • Nathan DM, Schreiber E, Fogel H, Mojsov S, Habener JF. Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects. Diabetes Care 1992;15:270-6
    • (1992) Diabetes Care , vol.15 , pp. 270-276
    • Nathan, D.M.1    Schreiber, E.2    Fogel, H.3    Mojsov, S.4    Habener, J.F.5
  • 25
    • 0141999599 scopus 로고    scopus 로고
    • Subcutaneous glucagon-like peptide-1 (7-36) amide is insulinotropic and can cause hypoglycaemia in fasted healthy subjects
    • Edwards CM, Todd JF, Ghatei MA, Bloom SR. Subcutaneous glucagon-like peptide-1 (7-36) amide is insulinotropic and can cause hypoglycaemia in fasted healthy subjects. Clin Sci (Lond) 1998;95:719-24
    • (1998) Clin Sci (Lond) , vol.95 , pp. 719-724
    • Edwards, C.M.1    Todd, J.F.2    Ghatei, M.A.3    Bloom, S.R.4
  • 26
    • 0031664857 scopus 로고    scopus 로고
    • Subcutaneous glucagon-like peptide-1 improves postprandial glycaemic control over a 3-week period in patients with early type 2 diabetes
    • Todd JF, Edwards CM, Ghatei MA, Mather HM, Bloom SR. Subcutaneous glucagon-like peptide-1 improves postprandial glycaemic control over a 3-week period in patients with early type 2 diabetes. Clin Sci (Lond) 1998;95:325-9
    • (1998) Clin Sci (Lond) , vol.95 , pp. 325-329
    • Todd, J.F.1    Edwards, C.M.2    Ghatei, M.A.3    Mather, H.M.4    Bloom, S.R.5
  • 27
    • 0031033531 scopus 로고    scopus 로고
    • Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM
    • Rachman J, Barrow BA, Levy JC, Turner RC. Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM. Diabetologia 1997;40:205-11
    • (1997) Diabetologia , vol.40 , pp. 205-211
    • Rachman, J.1    Barrow, B.A.2    Levy, J.C.3    Turner, R.C.4
  • 28
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 2002;359:824-30
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 29
    • 0141669196 scopus 로고    scopus 로고
    • Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes
    • Meneilly GS, Greig N, Tildesley H, Habener JF, Egan JM, Elahi D. Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes. Diabetes Care 2003;26:2835-41
    • (2003) Diabetes Care , vol.26 , pp. 2835-2841
    • Meneilly, G.S.1    Greig, N.2    Tildesley, H.3    Habener, J.F.4    Egan, J.M.5    Elahi, D.6
  • 31
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993;214:829-35
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 32
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 1995;80:952-7
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 33
    • 0034612348 scopus 로고    scopus 로고
    • Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
    • Marguet D, Baggio L, Kobayashi T, et al. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci USA 2000;97:6874-9
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6874-6879
    • Marguet, D.1    Baggio, L.2    Kobayashi, T.3
  • 34
    • 0037974604 scopus 로고    scopus 로고
    • Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
    • Conarello SL, Li Z, Ronan J, et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proc Natl Acad Sci USA 2003;100:6825-30
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6825-6830
    • Conarello, S.L.1    Li, Z.2    Ronan, J.3
  • 35
    • 0036228243 scopus 로고    scopus 로고
    • Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats
    • Pospisilik JA, Stafford SG, Demuth HU, et al. Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats. Diabetes 2002;51:943-50
    • (2002) Diabetes , vol.51 , pp. 943-950
    • Pospisilik, J.A.1    Stafford, S.G.2    Demuth, H.U.3
  • 36
    • 0036107064 scopus 로고    scopus 로고
    • Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
    • Reimer MK, Holst JJ, Ahren B. Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur J Endocrinol 2002;146:717-27
    • (2002) Eur J Endocrinol , vol.146 , pp. 717-727
    • Reimer, M.K.1    Holst, J.J.2    Ahren, B.3
  • 37
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • Pospisilik JA, Martin J, Doty T, et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes 2003;52:741-50
    • (2003) Diabetes , vol.52 , pp. 741-750
    • Pospisilik, J.A.1    Martin, J.2    Doty, T.3
  • 38
    • 0036312876 scopus 로고    scopus 로고
    • Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats
    • Sudre B, Broqua P, White RB, et al. Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats. Diabetes 2002;51:1461-9
    • (2002) Diabetes , vol.51 , pp. 1461-1469
    • Sudre, B.1    Broqua, P.2    White, R.B.3
  • 39
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    • Ahren B, Simonsson E, Larsson II, et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 2002;25:869-75
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahren, B.1    Simonsson, E.2    Larsson, I.I.3
  • 40
    • 0037777695 scopus 로고    scopus 로고
    • J-[[3-hydroxy-l-adamantylamino]acetyl]-2-cyano-(S)-pyrrolidine: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
    • Villhauer EB, Brinkman JA, Naderi GB, et al. J-[[3-hydroxy-l-adamantyl) amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem 2003;46:2774-89
    • (2003) J Med Chem , vol.46 , pp. 2774-2789
    • Villhauer, E.B.1    Brinkman, J.A.2    Naderi, G.B.3
  • 41
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26) - Role in the inactivation of regulatory peptides
    • Mentlein R. Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept 1999;85:9-24
    • (1999) Regul Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 42
    • 0027425034 scopus 로고
    • Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
    • Thorens B, Porret A, Buhler L, Deng SP, Morel P, Widmann C. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 1993;42:1678-82
    • (1993) Diabetes , vol.42 , pp. 1678-1682
    • Thorens, B.1    Porret, A.2    Buhler, L.3    Deng, S.P.4    Morel, P.5    Widmann, C.6
  • 43
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • Young AA, Gedulin BR, Bhavsar S, et al. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 1999;48:1026-34
    • (1999) Diabetes , vol.48 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3
  • 44
    • 0034456212 scopus 로고    scopus 로고
    • Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats
    • Szayna M, Doyle ME, Betkey JA, et al. Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology 2000;141:1936-41
    • (2000) Endocrinology , vol.141 , pp. 1936-1941
    • Szayna, M.1    Doyle, M.E.2    Betkey, J.A.3
  • 45
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999;48.-2270-6
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 46
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J, Wang X, Pineyro MA, Egan JM. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 1999;48:2358-66
    • (1999) Diabetes , vol.48 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3    Egan, J.M.4
  • 47
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucason-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, et al. Insulinotropic glucason-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000;49:741-8
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 48
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994;371:606-9
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 49
    • 0034602252 scopus 로고    scopus 로고
    • Sustained expression of exendin-4 does not perturb glucose homeostasis, beta-cell mass, or food intake in metallothionein-preproexendin transgenic mice
    • Baggio L, Adatia F, Bock T, Brubaker PL, Drucker DJ. Sustained expression of exendin-4 does not perturb glucose homeostasis, beta-cell mass, or food intake in metallothionein-preproexendin transgenic mice. J Biol Chem 2000;275:34471-7
    • (2000) J Biol Chem , vol.275 , pp. 34471-34477
    • Baggio, L.1    Adatia, F.2    Bock, T.3    Brubaker, P.L.4    Drucker, D.J.5
  • 50
    • 0035405821 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
    • Tourrel C, Bailbe D, Meile MJ, Kergoat M, Portha B. Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 2001;50:1562-70
    • (2001) Diabetes , vol.50 , pp. 1562-1570
    • Tourrel, C.1    Bailbe, D.2    Meile, M.J.3    Kergoat, M.4    Portha, B.5
  • 51
    • 0036381989 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
    • Wang Q, Brubaker PL. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia 2002;45:1263-73
    • (2002) Diabetologia , vol.45 , pp. 1263-1273
    • Wang, Q.1    Brubaker, P.L.2
  • 52
    • 0037341252 scopus 로고    scopus 로고
    • Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
    • Stoffers DA, Desai BM, DeLeon DD, Simmons RA. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes 2003;52:734-40
    • (2003) Diabetes , vol.52 , pp. 734-740
    • Stoffers, D.A.1    Desai, B.M.2    DeLeon, D.D.3    Simmons, R.A.4
  • 53
    • 0034814047 scopus 로고    scopus 로고
    • Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
    • Edwards CM, Stanley SA, Davis R, et al. Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am J Physiol Endocrinol Metab 2001;281:E155-61
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Edwards, C.M.1    Stanley, S.A.2    Davis, R.3
  • 54
    • 0036035521 scopus 로고    scopus 로고
    • Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans
    • Vella A, Shah P, Reed AS, Adkins AS, Basu R, Rizza RA. Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans. Diabetologia 2002;45:1410-15
    • (2002) Diabetologia , vol.45 , pp. 1410-1415
    • Vella, A.1    Shah, P.2    Reed, A.S.3    Adkins, A.S.4    Basu, R.5    Rizza, R.A.6
  • 55
    • 0036965113 scopus 로고    scopus 로고
    • The insulinotropic effect of acute exendin-4 administered to humans: Comparison of nondiabetic state to type 2 diabetes
    • Egan JM, Clocquet AR, Elahi D. The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes. J Clin Endocrinol Metab 2002;87:1282-90
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1282-1290
    • Egan, J.M.1    Clocquet, A.R.2    Elahi, D.3
  • 56
    • 0038497464 scopus 로고    scopus 로고
    • Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
    • Kolterman OG, Buse JB, Fineman MS, et al. Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab 2003;88:3082-9
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3082-3089
    • Kolterman, O.G.1    Buse, J.B.2    Fineman, M.S.3
  • 57
    • 0038178058 scopus 로고    scopus 로고
    • Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes
    • Egan JM, Meneilly GS, Elahi D. Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes. Am J Physiol Endocrinol Metab 2003;284:E1072-9
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Egan, J.M.1    Meneilly, G.S.2    Elahi, D.3
  • 58
    • 0037850667 scopus 로고    scopus 로고
    • Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes
    • Fineman MS, Bicsak TA, Shen LZ, et al. Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care 2003;26:2370-7
    • (2003) Diabetes Care , vol.26 , pp. 2370-2377
    • Fineman, M.S.1    Bicsak, T.A.2    Shen, L.Z.3
  • 59
    • 1342286610 scopus 로고    scopus 로고
    • Dose-response for 2-day glycemic improvement following a single injection of long-acting-release exenatide (synthetic exendin-4) in diabetic fatty zucker (ZDF) rats
    • Gedulin B, Smith P, Prickett K, et al. Dose-response for 2-day glycemic improvement following a single injection of long-acting-release exenatide (synthetic exendin-4) in diabetic fatty zucker (ZDF) rats. Diabetes 2003;52(suppl. 1):A109
    • (2003) Diabetes , vol.52 , Issue.1 SUPPL.
    • Gedulin, B.1    Smith, P.2    Prickett, K.3
  • 60
    • 0034108646 scopus 로고    scopus 로고
    • Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
    • Knudsen LB, Nielsen PF, Huusfeldt P, et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000;43:1664-9
    • (2000) J Med Chem , vol.43 , pp. 1664-1669
    • Knudsen, L.B.1    Nielsen, P.F.2    Huusfeldt, P.3
  • 61
    • 0035516188 scopus 로고    scopus 로고
    • Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats
    • Larsen PJ, Fledelius C, Knudsen LB, Tang-Christensen M. Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats. Diabetes 2001;50:2530-9
    • (2001) Diabetes , vol.50 , pp. 2530-2539
    • Larsen, P.J.1    Fledelius, C.2    Knudsen, L.B.3    Tang-Christensen, M.4
  • 62
    • 0036784675 scopus 로고    scopus 로고
    • The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice
    • Rolin B, Larsen MO, Gotfredsen CF, et al. The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice. Am J Physiol Endocrinol Metab 2002;283:E745-52
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Rolin, B.1    Larsen, M.O.2    Gotfredsen, C.F.3
  • 63
    • 0347125292 scopus 로고    scopus 로고
    • The endocrine pancreas in non-diabetic rats after short-term and long-term treatment with the long-acting GLP-1 derivative NN2211
    • Bock T, Pakkenberg B, Buschard K. The endocrine pancreas in non-diabetic rats after short-term and long-term treatment with the long-acting GLP-1 derivative NN2211. APMIS 2003;111:1117-24
    • (2003) APMIS , vol.111 , pp. 1117-1124
    • Bock, T.1    Pakkenberg, B.2    Buschard, K.3
  • 64
    • 0036676385 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects
    • Elbrond B, Jakobsen G, Larsen S, et al. Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects. Diabetes Care 2002;25:1398-404
    • (2002) Diabetes Care , vol.25 , pp. 1398-1404
    • Elbrond, B.1    Jakobsen, G.2    Larsen, S.3
  • 65
    • 0036066641 scopus 로고    scopus 로고
    • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
    • Juhl CB, Hollingdal M, Sturis J, et al. Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes 2002;51:424-9
    • (2002) Diabetes , vol.51 , pp. 424-429
    • Juhl, C.B.1    Hollingdal, M.2    Sturis, J.3
  • 66
    • 0038353630 scopus 로고    scopus 로고
    • The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose
    • Chang AM, Jakobsen G, Sturis J, et al. The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose. Diabetes 2003;52:1786-91
    • (2003) Diabetes , vol.52 , pp. 1786-1791
    • Chang, A.M.1    Jakobsen, G.2    Sturis, J.3
  • 67
    • 0037339649 scopus 로고    scopus 로고
    • Development and characterization of a glucagon-like peptide 1-albumin conjugate: The ability to activate the glucagon-like peptide 1 receptor in vivo
    • Kim JG, Baggio LL, Bridon DP, et al. Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo. Diabetes 2003;52:751-9
    • (2003) Diabetes , vol.52 , pp. 751-759
    • Kim, J.G.1    Baggio, L.L.2    Bridon, D.P.3
  • 68
    • 0031782440 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
    • Deacon CF, Knudsen LB, Madsen K, Wiberg FC, Jacobsen O, Holst JJ. Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity. Diabetologia 1998;41:271-8
    • (1998) Diabetologia , vol.41 , pp. 271-278
    • Deacon, C.F.1    Knudsen, L.B.2    Madsen, K.3    Wiberg, F.C.4    Jacobsen, O.5    Holst, J.J.6
  • 69
    • 0033005873 scopus 로고    scopus 로고
    • Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1
    • Burcelin R, Dolci W, Thorens B. Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1. Metabolism 1999;48:252-8
    • (1999) Metabolism , vol.48 , pp. 252-258
    • Burcelin, R.1    Dolci, W.2    Thorens, B.3
  • 70
    • 0034806376 scopus 로고    scopus 로고
    • Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent
    • Doyle ME, Greig NH, Holloway HW, Betkey JA, Bernier M, Egan JM. Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Endocrinology 2001;142:4462-8
    • (2001) Endocrinology , vol.142 , pp. 4462-4468
    • Doyle, M.E.1    Greig, N.H.2    Holloway, H.W.3    Betkey, J.A.4    Bernier, M.5    Egan, J.M.6
  • 71
    • 0037096140 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogue LY315902: Effect on intestinal motility and release of insulin and somatostatin
    • Naslund E, Skogar S, Efendic S, Hellstrom PM. Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin. Regul Pept 2002;106:89-95
    • (2002) Regul Pept , vol.106 , pp. 89-95
    • Naslund, E.1    Skogar, S.2    Efendic, S.3    Hellstrom, P.M.4
  • 72
    • 0346098008 scopus 로고    scopus 로고
    • Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo
    • Green BD, Gault VA, Mooney MH, et al. Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo. J Mol Endocrinol 2003;31:529-40
    • (2003) J Mol Endocrinol , vol.31 , pp. 529-540
    • Green, B.D.1    Gault, V.A.2    Mooney, M.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.