Cytokine release does not improve the sensitivity and specificity of the direct popliteal lymph node assay

Toxicology

Volumn 200, Issue 2-3, 2004, Pages 247-254

  Ravel, Guillaume ^a,b   Christ, Marielle ^a   Horand, Françoise ^a   Descotes, Jacques ^b  

^a MDS Pharma Services   (France)

^b Poison Center   (France)

Author keywords

Autoimmunity; Hypersensitivity; Immunotoxicology; Popliteal lymph node assay

Indexed keywords

CYTOKINE; DICLOFENAC; GAMMA INTERFERON; GLAFENINE; HYDRALAZINE; IMIPRAMINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MINOCYCLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P70; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ASSAY; CELL SUSPENSION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG SCREENING; FEMALE; FLOW CYTOMETRY; LEG; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM; TH1 CELL; TH2 CELL;

ANIMALS; AUTOIMMUNITY; CELLS, CULTURED; CYTOKINES; DRUG HYPERSENSITIVITY; FEMALE; FLOW CYTOMETRY; INFLAMMATION MEDIATORS; LOCAL LYMPH NODE ASSAY; MICE; MICE, INBRED BALB C; TH1 CELLS; TH2 CELLS;

EID: 2942711377     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.03.010     Document Type: Article

References (34)

1. Bigazzi P.L. Autoimmunity induced by xenobiotics. Toxicology. 119:1997;1-21
2. Bloksma N., Kubicka-Muranyi M., Schuppe H.C., Gleichmann E., Gleichmann H. Predictive immunotoxicological test systems: suitability of the popliteal lymph node assay in mice and rats. Crit. Rev. Toxicol. 25:1995;369-396
3. Britschgi M., von Greyerz S., Burkhart C., Pichler W.J. Molecular aspects of drug recognition by specific T cells. Curr. Drug Targets. 4:2003;1-11
4. Brouland J.-P., Verdier F., Patriarca C., Vial T., Descotes J. Morphology of popliteal lymph node responses in Brown-Norway rats. J. Toxicol. Environ. Health. 41:1994;95-108
5. Choquet-Kastvlevsky G., Tedone R., Descot J. Positive responses to imipramine in the popliteal lymph node assay are due to primary irritation. Hum. Exp. Toxicol. 20:2001;591-595
6. Descotes J. The popliteal lymph node assay: a tool for studying the mechanism of drug-induced autoimmune disorders. Toxicol. Lett. 64-65:1992;101-107
7. Eichenfield A.H. Minocycline and autoimmunity. Curr. Opin. Pediatr. 11:1999;447-456
8. Goebel C., Griem P., Sachs B., Bloksma N., Gleichmann E. The popliteal lymph node assay in mice: screening of drugs and other chemicals for immunotoxic hazard. Inflamm. Res. 45(Suppl. 2):1996;85-90
9. Griem P., Wulferink M., Sachs B., González J.B., Gleichmann E. Allergic and autoimmune reactions to xenobiotics: how do they arise? Immunol. Today. 19:1998;133-141
10. Gruchalla R.S. Drug allergy. J. Allergy Clin. Immunol. 111(Suppl. 2):2003;548-559
11. Gutting B.W., Schomaker S.J., Kaplan A.H., Amacher D.E. A comparison of the direct and reporter antigen popliteal lymph node assay for the detection of immunomodulation by low molecular weight compounds. Toxicol. Sci. 51:1999;71-79
12. Hastings K.L. Pre-clinical methods for detecting the hypersensitivity potential of pharmaceuticals: regulatory considerations. Toxicology. 158:2001;85-89
13. Hou W., Wu Y., Sun S., Shi M., Sun Y., Yang C., Pei G., Gu Y., Zhong C., Sun B. Pertussis toxin enhances Th1 responses by stimulation of dendritic cells. J. Immunol. 170:2003;1728-1736
14. + lymphocyte subsets by streptozotocin in murine popliteal lymph node test. J. Autoimmun. 5:1992;183-197
15. Kubicka-Muranyi M., Goebels R., Goebel C., Uetrecht J., Gleichmann E. T lymphocytes ignore procainamide, but respond to its reactive metabolites in peritoneal cells: demonstration by the adoptive transfer popliteal lymph node assay. Toxicol. Appl. Pharmacol. 122:1993;88-94
16. Naisbitt D.J., Gordon S.F., Pirmohamed M., Park B.K. Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment. Drug Saf. 23:2000;483-507
17. Overbergh L., Giulietti A., Valckx D., Decallonne R., Bouillon R., Mathieu C. The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J. Biomol. Tech. 14:2003;33-43
18. Patriarca C., Verdier F., Brouland J.-P., Descotes J. Popliteal lymph node response to procainamide and isoniazid. Role of beta-naphthoflavone, phenobarbitone and S9-mix pretreatment. Toxicol. Lett. 66:1993;21-28
19. Pichler W.J. Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept. Curr. Opin. Allergy Clin. Immunol. 2:2002;301-305
20. Pichler W.J. Drug-induced autoimmunity. Curr. Opin. Allergy Clin. Immunol. 3:2003;249-253
21. Pieters R. The popliteal lymph node assay in predictive testing for autoimmunity. Toxicol. Lett. 112-113:2000;453-459
22. Pieters R. The popliteal lymph node assay: a tool for predicting drug allergies. Toxicology. 158:2001;65-69
23. Pieters R., Ezendam J., Bleumink R., Bol M., Nierkens S. Predictive testing for autoimmunity. Toxicol. Lett. 127:2002;83-91
24. Pieters R., Ezendam J., Nierkens S. Chemical-specific properties co-determine the type of adverse immune response. Autoimmun. Rev. 2:2003;25-29
25. Price E.J., Venables P.J. Drug-induced lupus. Drug Saf. 12:1995;283-290
26. Roger I., Douvin D., Bécourt N., Legrain B. Procainamide (PA) and popliteal lymph node assay (PLNA): false positive response? Toxicologist. 14:1994;324
27. Ruat C., Faure L., Choquet-Kastylevsky G., Ravel G., Descotes J. Tritiated thymidine incorporation does not enhance sensitivity of the popliteal lymph node assay. Toxicology. 188:2003;29-33
28. Suda A., Iwaki Y., Kimura M. Differentiation of responses to allergenic and irritant compounds in mouse popliteal lymph node assay. J. Toxicol. Sci. 25:2000;131-136
29. Thomas C., Groten J., Kammüller M.E., De Bakker J.M., Seinen W., Bloksma N. Popliteal lymph node reactions in mice induced by the drug zimeldine. Int. J. Immunopharmacol. 11:1989;693-702
30. Thomas C., Lippe W., Seinen W., Bloksma N. Popliteal lymph node enlargement and antibody production in the mouse induced by drugs affecting monoamine levels in the brain. Int. J. Immunopharmacol. 13:1991;621-629
31. Tuschl H., Landsteiner H.T., Kovac R. Application of the popliteal lymph node assay in immunotoxicity testing: complementation of the direct popliteal lymph node assay with flow cytometric analyses. Toxicology. 172:2002;35-48
32. Uetrecht J.P. Is it possible to more accurately predict which drug candidates will cause idiosyncratic drug reactions? Curr. Drug Metab. 1:2000;133-141
33. van der Klauw M.M., Wilson J.H., Stricker B.H. Drug-associated anaphylaxis: 20 years of reporting in The Netherlands (1974-1994) and review of the literature. Clin. Exp. Allergy. 26:1996;1355-1363
34. Vial T., Carleer J., Legrain B., Verdier F., Descotes J. The popliteal lymph node assay: results of a preliminary interlaboratory validation study. Toxicology. 122:1997;213-218